ID A0A1W6YP93_9BORD Unreviewed; 765 AA.
AC A0A1W6YP93;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN ORFNames=CAL12_17260 {ECO:0000313|EMBL:ARP82393.1};
OS Bordetella genomosp. 8.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Alcaligenaceae; Bordetella.
OX NCBI_TaxID=1416806 {ECO:0000313|EMBL:ARP82393.1, ECO:0000313|Proteomes:UP000194151};
RN [1] {ECO:0000313|EMBL:ARP82393.1, ECO:0000313|Proteomes:UP000194151}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AU19157 {ECO:0000313|EMBL:ARP82393.1,
RC ECO:0000313|Proteomes:UP000194151};
RA Spilker T., LiPuma J.;
RT "Complete and WGS of Bordetella genogroups.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; CP021108; ARP82393.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1W6YP93; -.
DR STRING; 1416806.CAL12_17260; -.
DR OrthoDB; 5905204at2; -.
DR Proteomes; UP000194151; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 3..280
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 281..581
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 682..705
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 24..31
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 765 AA; 84615 MW; 6B50AD52ECE63504 CRC64;
MIDKLNPEQR AAVTLEPQHA LVLAGAGSGK TRVLTTRMAW LIQNGLASPY ALLAVTFTNK
AAREMLARIT AILPIDTRGL WVGTFHGLCN RLLRAHHRDA GLPQAFQILD TADQLAAIKR
LLKANGIDDE KYPPRDVQRF INGAKEEGQR PGELEAWDSH RRRLIEIYQL YEAQCQREGV
VDFPELLLRA YELLSRNAPV REHYQRRFRH ILVDEFQDTN TLQYKWLRLL AGGGAHIFAV
GDDDQSIYAF RGANVGNMAD FERDYAHGTV IRLEQNYRSY GHILDAANAL IDHNSGRLGK
NLWTEQGEGE PVRVIEQPSD GMEAQWVVDE IRALVNDGRA RREIAVLYRS NAQSRVLEHA
LFSAAIPYKV YGGLRFFERQ EIKHALAYLR LIANPHDDTS WMRVVNFPAR GIGARTLEQL
ADAARAHDTS LYGAVARVAG KGGANLAQFA ALIGRMADDT RELPLPEMVE HVLEASGLIE
HYRGEKEGTE RIENLNELVN AAAVFSTEEN FDGLPAGVAA QREPIPGPDA AGATDPAFAA
PAENLTPLAA FLSHAALEAG DNQAQAGQDA VQMMTVHAAK GLEFDAVFIT GLEEGLFPHE
NSVLEQAGLE EERRLMYVAI TRARERLYLS LAQSRMLHGQ TRYAMRSRFL GEIPEQHLKW
LTPRATMGDE YGAANRDWRG ADRDAFGRKP TGTIAPRQPR GVASGVTVGD RQYRIGQGVR
HARFGDGTII GLSGNGQDAQ AQIQFRDVGP KTLALGIAKL DVIAG
//
