ID   A0A1W7CZB5_9ACTN        Unreviewed;       806 AA.
AC   A0A1W7CZB5;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Sarcosine dehydrogenase {ECO:0000313|EMBL:ARQ70009.1};
GN   ORFNames=CAG99_15110 {ECO:0000313|EMBL:ARQ70009.1};
OS   Streptomyces marincola.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=2878388 {ECO:0000313|EMBL:ARQ70009.1, ECO:0000313|Proteomes:UP000194218};
RN   [1] {ECO:0000313|EMBL:ARQ70009.1, ECO:0000313|Proteomes:UP000194218}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SCSIO 03032 {ECO:0000313|EMBL:ARQ70009.1,
RC   ECO:0000313|Proteomes:UP000194218};
RA   Ma L., Zhu Y., Zhang W., Zhang G., Tian X., Zhang S., Zhang C.;
RT   "Complete genome sequence of Streptomyces sp. SCSIO 03032 revealed the
RT   diverse biosynthetic pathways for its bioactive secondary metabolites.";
RL   Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the GcvT family.
CC       {ECO:0000256|ARBA:ARBA00008609}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP021121; ARQ70009.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1W7CZB5; -.
DR   KEGG; smao:CAG99_15110; -.
DR   OrthoDB; 2055370at2; -.
DR   Proteomes; UP000194218; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.30.110; Aminomethyltransferase beta-barrel domains; 1.
DR   Gene3D; 3.30.70.1400; Aminomethyltransferase beta-barrel domains; 1.
DR   Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR006076; FAD-dep_OxRdtase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR032503; FAO_M.
DR   InterPro; IPR028896; GCST/YgfZ/DmdA.
DR   InterPro; IPR013977; GCV_T_C.
DR   InterPro; IPR006222; GCV_T_N.
DR   InterPro; IPR029043; GcvT/YgfZ_C.
DR   InterPro; IPR027266; TrmE/GcvT_dom1.
DR   PANTHER; PTHR43757; AMINOMETHYLTRANSFERASE; 1.
DR   PANTHER; PTHR43757:SF2; AMINOMETHYLTRANSFERASE, MITOCHONDRIAL; 1.
DR   Pfam; PF01266; DAO; 1.
DR   Pfam; PF16350; FAO_M; 1.
DR   Pfam; PF01571; GCV_T; 1.
DR   Pfam; PF08669; GCV_T_C; 1.
DR   SUPFAM; SSF101790; Aminomethyltransferase beta-barrel domain; 1.
DR   SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   SUPFAM; SSF103025; Folate-binding domain; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000194218}.
FT   DOMAIN          8..355
FT                   /note="FAD dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF01266"
FT   DOMAIN          358..412
FT                   /note="FAD dependent oxidoreductase central"
FT                   /evidence="ECO:0000259|Pfam:PF16350"
FT   DOMAIN          416..692
FT                   /note="Aminomethyltransferase folate-binding"
FT                   /evidence="ECO:0000259|Pfam:PF01571"
FT   DOMAIN          716..798
FT                   /note="Glycine cleavage T-protein C-terminal barrel"
FT                   /evidence="ECO:0000259|Pfam:PF08669"
SQ   SEQUENCE   806 AA;  86139 MW;  4B7BF704EE41BC6C CRC64;
     MAARADTRVV IIGAGIVGCA LADELTSRGL RDVTVLDRGP LFAGPGSSYH APGLVFATSP
     AKVLSDFARY TIDKYRSLGC FSPVGGLEVA TTPERLADLA RRAGLAASWG IEAERVSARR
     CAELWPLLGA DRVLGGLYTP HDGLADAALA CRLQAERAMA RGATFHGGHT VTGIERGPDG
     AVVAVRTDRG DVPADAVVSA AGFWGPVIGA MAGVAVPLLP LAHQYARTAP VPGLDPDARL
     PILRHQDRDL YVRQHGDTLG IGSYGHRPMP VDPFTLTASE LPFSPEEFAP AWRDAAELLP
     ALGGAGPPSG FDGVFSFTPD GMPLLGQVRE VPGLWLAEAV WVTHSAGAAR AVAQWLTEGR
     PTTDTHLCDV HRFTGAQLSP AYITDRGAQS FVEVYDMIHP LDPPARPRPL RVGPFHVKHR
     ELGAYQLEYA GWERPQWFEA NAPLAEALPP GAVPPRDAWA ARHWSPVAAA EALATRERVA
     LFDMTPLTRL EVTGPGALAF LRRMTTGRVD RRPGSVGYAL LLDHGGGVRS DITVARLARD
     HWQIGCNGPL DLDWLLRHAP SDGSVAVRDI TPGTCCLGVW GPLARELVAP LADADVSHEA
     FGYFTARRLH IGHVPVTAMR LSYVGELGWE LYTTADLGPL LWDTLWRAGQ RLGVLAAGRA
     AFTSLRLEKG YRAWGTDMTT EHDPYEAGLG FALRPGDRDF IGGAALADRS EATARRRLAC
     LTLDDPAAIV LGGEPVYAAD EPARPAGYVT SAGYGHTVGR AIVYAWLPAA LAVPGTGTHV
     AYFGERLAAT VRAEPLLDPE MSRIRR
//