ID A0A1W7D1K8_9ACTN Unreviewed; 844 AA.
AC A0A1W7D1K8;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Trehalose 6-phosphate phosphorylase {ECO:0000313|EMBL:ARQ70916.1};
GN ORFNames=CAG99_20575 {ECO:0000313|EMBL:ARQ70916.1};
OS Streptomyces marincola.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2878388 {ECO:0000313|EMBL:ARQ70916.1, ECO:0000313|Proteomes:UP000194218};
RN [1] {ECO:0000313|EMBL:ARQ70916.1, ECO:0000313|Proteomes:UP000194218}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SCSIO 03032 {ECO:0000313|EMBL:ARQ70916.1,
RC ECO:0000313|Proteomes:UP000194218};
RA Ma L., Zhu Y., Zhang W., Zhang G., Tian X., Zhang S., Zhang C.;
RT "Complete genome sequence of Streptomyces sp. SCSIO 03032 revealed the
RT diverse biosynthetic pathways for its bioactive secondary metabolites.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 65 family.
CC {ECO:0000256|ARBA:ARBA00006768}.
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DR EMBL; CP021121; ARQ70916.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1W7D1K8; -.
DR KEGG; smao:CAG99_20575; -.
DR OrthoDB; 9816160at2; -.
DR Proteomes; UP000194218; Chromosome.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 1.50.10.10; -; 1.
DR Gene3D; 2.70.98.40; Glycoside hydrolase, family 65, N-terminal domain; 1.
DR Gene3D; 2.60.420.10; Maltose phosphorylase, domain 3; 1.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR005194; Glyco_hydro_65_C.
DR InterPro; IPR005195; Glyco_hydro_65_M.
DR InterPro; IPR005196; Glyco_hydro_65_N.
DR InterPro; IPR037018; Glyco_hydro_65_N_sf.
DR InterPro; IPR017045; Malt_Pase/Glycosyl_Hdrlase.
DR PANTHER; PTHR11051; GLYCOSYL HYDROLASE-RELATED; 1.
DR PANTHER; PTHR11051:SF8; PROTEIN-GLUCOSYLGALACTOSYLHYDROXYLYSINE GLUCOSIDASE; 1.
DR Pfam; PF03633; Glyco_hydro_65C; 1.
DR Pfam; PF03632; Glyco_hydro_65m; 1.
DR Pfam; PF03636; Glyco_hydro_65N; 1.
DR PIRSF; PIRSF036289; Glycosyl_hydrolase_malt_phosph; 2.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW Reference proteome {ECO:0000313|Proteomes:UP000194218};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 16..296
FT /note="Glycoside hydrolase family 65 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF03636"
FT DOMAIN 348..744
FT /note="Glycoside hydrolase family 65 central catalytic"
FT /evidence="ECO:0000259|Pfam:PF03632"
FT DOMAIN 754..815
FT /note="Glycoside hydrolase family 65 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03633"
FT REGION 97..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 431..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 824..844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 525
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR036289-50"
FT BINDING 386..387
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR036289-51"
FT BINDING 645..646
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR036289-51"
SQ SEQUENCE 844 AA; 93939 MW; 0E7F9D6A8C8F19DB CRC64;
MTEPASREST EWTWAYEGYD PRAERLREAL CTLGNGYFAT RGAAPESVAG PAHYPGTYAA
GLYNRLTTTL DGRELEHEDV VNLPNWLAFR FRPHPDEGPD GEWFTPDPGH APGAEPGPDR
EPAGHGHGHG RLLRYRQVLD LRHGTLGRSV RYRDRHGRHL GVEQCRLVHM ADPHLAALRT
TFTAEDWSGT IEVESAIDGM AAANTGVERY RDLASHHLTD MGTGSEDPDL VWLRCRTRAS
DIRVVMAART RADAEPDRLT PPTRLTDYRA EQRLRLPIGP GRPVTVEKTI ALHTSRDTAI
SSPLGAAVDR LRRAPDFDGL LDTHGAAWER LWRRADLDVP GESGHILRLH LFHLLQTLSP
GHTARLDAGV PARGLHGEAY RGHVFWDELF VLPYLNLHFP ELSRALMTYR YRRLPAALRA
ARAAGREGAM FPWQSGSDGR EETPETHLNP RSGRWLPDNS RLQHHVGSAV AYNVWRYGQA
TGDTGFTHAE GAELLLQIAR FWASRAEFDP AYERYRIRGV VGPDEYHEAY PDASEPGLDD
NAYTNVTAAW VLARALDLAR ALPASRRREL SERIGLRPEE PELWEEVSRR LRVPFHEGVV
SQFDGYGELR ELDWEGYRAR YGDIRRLDRV LEAEGDTVNR YRASKQADVL MLGYLFSPGE
LAEVFARLGY AMDDALWRRT VDYYLARTSH GSTLSGVVHA WVLSRVRHGE AWRHLKEALA
SDVADLQGGT TAEGIHLGAM AGTLDLVQRG LAGLQTREGA LWLDPAPVPE LSEFGFTVRH
RGTAVRVRMK PGQLCVGVPG SEEGPVRVVL ADDTVDIAPG EERLLALPRE PGRPAPGTAP
PGGV
//
