ID   A0A1W9HQ78_9PROT        Unreviewed;       568 AA.
AC   A0A1W9HQ78;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
GN   ORFNames=A4S15_02280 {ECO:0000313|EMBL:OQW49576.1};
OS   Proteobacteria bacterium SG_bin8.
OC   Bacteria; Pseudomonadota.
OX   NCBI_TaxID=1827387 {ECO:0000313|EMBL:OQW49576.1, ECO:0000313|Proteomes:UP000192872};
RN   [1] {ECO:0000313|EMBL:OQW49576.1, ECO:0000313|Proteomes:UP000192872}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SG_bin8 {ECO:0000313|EMBL:OQW49576.1};
RX   PubMed=28390307; DOI=10.1016/j.watres.2017.03.042;
RA   Wang Y., Ma L., Mao Y., Jiang X., Xia Y., Yu K., Li B., Zhang T.;
RT   "Comammox in drinking water systems.";
RL   Water Res. 116:332-341(2017).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OQW49576.1}.
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DR   EMBL; LWDL01000031; OQW49576.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1W9HQ78; -.
DR   STRING; 1827387.A4S15_02280; -.
DR   Proteomes; UP000192872; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 3.90.1580.10; paralog of FGE (formylglycine-generating enzyme); 1.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR016187; CTDL_fold.
DR   InterPro; IPR005532; SUMF_dom.
DR   InterPro; IPR042095; SUMF_sf.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR23150:SF35; BLL6746 PROTEIN; 1.
DR   PANTHER; PTHR23150; SULFATASE MODIFYING FACTOR 1, 2; 1.
DR   Pfam; PF03781; FGE-sulfatase; 1.
DR   Pfam; PF13676; TIR_2; 1.
DR   SUPFAM; SSF56436; C-type lectin-like; 1.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        219..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..124
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
FT   REGION          166..214
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        176..192
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        193..209
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   568 AA;  62477 MW;  0FDEE8431EDE19A1 CRC64;
     MADVFISYKS DRRAAVEHLT RILELNGYSV WFDYGLLSGQ NFARQIEREI RAAKVVLVLW
     CQLSVDSEWV NGEARLATRL GKMIPAWIQD VDLPLEFNGA DTINLEHWDG SPRSHVLDRL
     FEQIGARVGR EQVPQIAGLK DFDSLWRRYG APNLLSFPLE KVIPEFEKND GSPSEARHVT
     SRPSVTPSDE PVDKSGQDNR SDGHSAAARE KKTGSSSAFL MFTAGLLLAA LLGGGGYATW
     HYLRPAAQPP IIVPPPVEAQ TAIIAPRPVE TQTPIVTPPQ VIAPPPIETQ TAVIAPLTLP
     SPSRERTPGR SENQFRDCEA CPLMVMIPEG KFLIGSPDAE SGHKANEAPR REISIKRKFA
     IARLEVSFAE WDACVADSGC RSYRPNDYGM GRGNSPVIFV SFFDAIAYAA WMSTKTGATY
     RLPSEAEWEF AARGCIAAGC ANDPFGFGGD IGPDLANYNW NTAYNGSLRR QPRRQTMAVE
     EGSKANGFGL LHVHGNVAEW VQDCVNGSYD RLPENGAPAT SGDCRSRVVR GGNWNDNPRE
     LRSSARAFEE ATTRSHLIGF RLARDLTK
//