ID   A0A1W9HSS4_9PROT        Unreviewed;       561 AA.
AC   A0A1W9HSS4;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   08-NOV-2023, entry version 19.
DE   SubName: Full=Phenylalanine 4-monooxygenase {ECO:0000313|EMBL:OQW50515.1};
GN   ORFNames=A4S09_01605 {ECO:0000313|EMBL:OQW50515.1};
OS   Proteobacteria bacterium SG_bin7.
OC   Bacteria; Pseudomonadota.
OX   NCBI_TaxID=1827384 {ECO:0000313|EMBL:OQW50515.1, ECO:0000313|Proteomes:UP000192385};
RN   [1] {ECO:0000313|EMBL:OQW50515.1, ECO:0000313|Proteomes:UP000192385}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SG_bin7 {ECO:0000313|EMBL:OQW50515.1};
RX   PubMed=28390307; DOI=10.1016/j.watres.2017.03.042;
RA   Wang Y., Ma L., Mao Y., Jiang X., Xia Y., Yu K., Li B., Zhang T.;
RT   "Comammox in drinking water systems.";
RL   Water Res. 116:332-341(2017).
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000256|ARBA:ARBA00001954,
CC         ECO:0000256|PIRSR:PIRSR601273-2};
CC   -!- SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid
CC       hydroxylase family. {ECO:0000256|ARBA:ARBA00009712}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OQW50515.1}.
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DR   EMBL; LWDK01000030; OQW50515.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1W9HSS4; -.
DR   STRING; 1827384.A4S09_01605; -.
DR   Proteomes; UP000192385; Unassembled WGS sequence.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0016714; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen; IEA:InterPro.
DR   GO; GO:0009072; P:aromatic amino acid metabolic process; IEA:InterPro.
DR   Gene3D; 1.20.58.690; -; 1.
DR   Gene3D; 1.10.800.10; Aromatic amino acid hydroxylase; 1.
DR   InterPro; IPR001273; ArAA_hydroxylase.
DR   InterPro; IPR036951; ArAA_hydroxylase_sf.
DR   InterPro; IPR036329; Aro-AA_hydroxylase_C_sf.
DR   InterPro; IPR019774; Aromatic-AA_hydroxylase_C.
DR   PANTHER; PTHR11473; AROMATIC AMINO ACID HYDROXYLASE; 1.
DR   PANTHER; PTHR11473:SF24; PHENYLALANINE-4-HYDROXYLASE; 1.
DR   Pfam; PF00351; Biopterin_H; 2.
DR   SUPFAM; SSF56534; Aromatic aminoacid monoxygenases, catalytic and oligomerization domains; 1.
DR   PROSITE; PS51410; BH4_AAA_HYDROXYL_2; 1.
PE   3: Inferred from homology;
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR601273-2};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRSR:PIRSR601273-2};
KW   Monooxygenase {ECO:0000256|ARBA:ARBA00023033, ECO:0000313|EMBL:OQW50515.1};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          1..338
FT                   /note="Biopterin-dependent aromatic amino acid hydroxylase
FT                   family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51410"
FT   BINDING         127
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT   BINDING         132
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT   BINDING         217
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
SQ   SEQUENCE   561 AA;  63241 MW;  D89B4F52F6BE0F13 CRC64;
     MELESLVSKL PRHLRRYIVD QDYSRYTPID QAVWRYIMRR LTNFLSDHAH PAYMEGLNKT
     GIEVDRIPDI ARMNDFLKKF GWQALPVSGF IPPAAFMELQ SLSILPIASD MRTVDHILYT
     PAPDIVHEAA GHAPILVDPK FASYLKKYSQ VAKKAIISSE DLELYEAIRE LSDIKESPES
     TKEQIKNAEK HLEKVSANMT HVSEAGLLGR MNWWTAEYGL IGDLNHPKIF GAGLLSSVGE
     AKECLDPKIK KIPLTVDCID YSYNITEPQP QLFVTPTFEN LEKALEDLAN TMAFRTGGVA
     GLERALQAKT INTTEFSTGL QVSGVLTKIY NRRDSHQPDY LSFTGPCTLS HRNKIIKGHG
     LDRHPEGFGS PVGKIVDLIK FHVGQRRVVE FPSGVKVDGV ISNIFHQDGR VLIVTFQNCT
     VTYGNEVLFE PSWGEYDMAV GDRIVSVFGG PADHSSFDDT KDFPVKVIPR RKFSIGELAL
     HSLYTRVREI RENNLEAEKE LSEILAGVKS NFPNEWLIVL EIYELTKSQD SLEVLQEIAK
     KFPDKKEQIE SGIEIAEKKK I
//