ID A0A1W9I688_9PROT Unreviewed; 1163 AA.
AC A0A1W9I688;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN ORFNames=A4S14_13590 {ECO:0000313|EMBL:OQW55199.1};
OS Proteobacteria bacterium SG_bin9.
OC Bacteria; Pseudomonadota.
OX NCBI_TaxID=1827385 {ECO:0000313|EMBL:OQW55199.1, ECO:0000313|Proteomes:UP000192684};
RN [1] {ECO:0000313|EMBL:OQW55199.1, ECO:0000313|Proteomes:UP000192684}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SG_bin9 {ECO:0000313|EMBL:OQW55199.1};
RX PubMed=28390307; DOI=10.1016/j.watres.2017.03.042;
RA Wang Y., Ma L., Mao Y., Jiang X., Xia Y., Yu K., Li B., Zhang T.;
RT "Comammox in drinking water systems.";
RL Water Res. 116:332-341(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQW55199.1}.
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DR EMBL; LWDM01000065; OQW55199.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1W9I688; -.
DR STRING; 1827385.A4S14_13590; -.
DR Proteomes; UP000192684; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014151; DNA_helicase_AddA.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR02784; addA_alphas; 1.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 9..490
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 521..796
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 967..986
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 968..986
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 30..37
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1163 AA; 128446 MW; DDBFD6AC14BE826D CRC64;
MSEPRSQIPA LARDAQTRSS NPATSVFVSA NAGSGKTHVL VQRVVRLLLA GVPPAKILCI
TFTKAAAANM SQRVFAKLGE WVALGDDALD RALKESGIAR STAQIRMQAR KLFANALETP
GGLKVQTIHA LCTRLLQQFP FEANVPARFA VLDDRDQADM MEHASLKVLL DAAAKPMSPI
GRALQTAMAT AADTTFREVV TEAVLSRDHL LTWIKQAGGV EAAVGELSRA LAIDPDESIE
EIEREIVAGP NLPRSRWAAV SDILESGNKT DRDQAERLRY ALELNGSAQV EKYFTVFLTK
DAEMRKVLVT REIRDNAPSI AASFEAEKAR LGPLIDRRRA AFTRDRTHAL LAIATAVADN
YRFAKQARGA MDYSDLIEKT LRLLDNTSAG WVHYKLDRGV DHVLIDEAQD TSPQQWDIVA
RLISEFTTGA GAREAKRTVF AVGDEKQSIF SFQGAAPREF DARRRELEQR FREAKLEFEK
ISFTYSFRSG AGVLQAVEST FKPQDIYRSI TTDRDGMPPH MALTDAAPSS IDLWELELPP
ERKDMEGWRV PFDAVSRTNP EVVLANRIQR EIKAIIARGE LTGVAGRRRK LTYGDVLVLV
RRRGKAFDAV IKALKHAGVP VAGADRLKLT EHIAVIDLMS LGDALLLPKD DLALAVALKS
PLFGLDEEQL FALAWNRKGS LRAAIEDKAK SDATFANVLR RLTACEERVQ HDTPFAFYAW
LLGADGGRAR IMQRLGAEAN DALDEFLELA LGYERRAPAS LQSFLAWLRA ADTEIKRDME
IARDEVRVMT VHGAKGLEAP VVFLADTTVS PTETQRVNLV RIPQGNDAPS AAGLTVWAGR
KADDPALVAS ARETMKGEMD DEYRRLLYVA MTRAADRLIV GGCLPGNRRE VSPTSWYALI
REGLKRSGLV EAKIETDDGS VFRYSKSDDL GAPADLFSID RAKPPIELPD WLRTPDQPRP
ASRALIRPSA RNDSNGTSAH ALSPNQRERA LQRGNLVHRL LQSLPEIPSE RRRDAALRFL
ARNATDSDGW TDVERSTLAE QVLALMEDTR FAHVFAEGSR AEVPVVGRLP EMSDAPVSGQ
IDRLLIAPNQ IWIVDFKTNA AAPRQLADVP QAYVRQLALY RRVLALAYPG RLIRAALLWT
EIPEIMEIPT VNLDQAMASL ISS
//
