ID   A0A1W9I7A1_9PROT        Unreviewed;       984 AA.
AC   A0A1W9I7A1;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Lactate dehydrogenase {ECO:0000313|EMBL:OQW55482.1};
GN   ORFNames=A4S14_12585 {ECO:0000313|EMBL:OQW55482.1};
OS   Proteobacteria bacterium SG_bin9.
OC   Bacteria; Pseudomonadota.
OX   NCBI_TaxID=1827385 {ECO:0000313|EMBL:OQW55482.1, ECO:0000313|Proteomes:UP000192684};
RN   [1] {ECO:0000313|EMBL:OQW55482.1, ECO:0000313|Proteomes:UP000192684}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SG_bin9 {ECO:0000313|EMBL:OQW55482.1};
RX   PubMed=28390307; DOI=10.1016/j.watres.2017.03.042;
RA   Wang Y., Ma L., Mao Y., Jiang X., Xia Y., Yu K., Li B., Zhang T.;
RT   "Comammox in drinking water systems.";
RL   Water Res. 116:332-341(2017).
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OQW55482.1}.
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DR   EMBL; LWDM01000060; OQW55482.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1W9I7A1; -.
DR   STRING; 1827385.A4S14_12585; -.
DR   Proteomes; UP000192684; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.465.10; -; 1.
DR   Gene3D; 3.30.70.2740; -; 1.
DR   InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR   InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR   InterPro; IPR004017; Cys_rich_dom.
DR   InterPro; IPR004113; FAD-bd_oxidored_4_C.
DR   InterPro; IPR016166; FAD-bd_PCMH.
DR   InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR   InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR   InterPro; IPR016164; FAD-linked_Oxase-like_C.
DR   InterPro; IPR006094; Oxid_FAD_bind_N.
DR   PANTHER; PTHR11748:SF119; D-2-HYDROXYGLUTARATE DEHYDROGENASE; 1.
DR   PANTHER; PTHR11748; D-LACTATE DEHYDROGENASE; 1.
DR   Pfam; PF02754; CCG; 1.
DR   Pfam; PF02913; FAD-oxidase_C; 1.
DR   Pfam; PF01565; FAD_binding_4; 1.
DR   Pfam; PF13183; Fer4_8; 1.
DR   SUPFAM; SSF46548; alpha-helical ferredoxin; 1.
DR   SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR   SUPFAM; SSF55103; FAD-linked oxidases, C-terminal domain; 1.
DR   PROSITE; PS00198; 4FE4S_FER_1; 1.
DR   PROSITE; PS51379; 4FE4S_FER_2; 1.
DR   PROSITE; PS51387; FAD_PCMH; 1.
PE   4: Predicted;
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT   DOMAIN          47..271
FT                   /note="FAD-binding PCMH-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51387"
FT   DOMAIN          626..656
FT                   /note="4Fe-4S ferredoxin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51379"
SQ   SEQUENCE   984 AA;  106967 MW;  52FBB2111DC17279 CRC64;
     MAAHHKHERV ISGADSALAA KLSREITGDV LFDPFSRGRY ATDASFYQIV PFGVVVPKTI
     DEALRAMAIA RDDGRKVTPR GGGTSQCGQT INDGIVVDGS KHLNKILSLD VENRTCVVQP
     GIVLDDLNRQ LKKHGLWFPV DVSTASRATI GGMAGNNSCG GRSLRYGTMR DNTLSMEAAL
     ADGTLLRFGP TDRDPVNDDP SGGLFRDMLA LGAREAGEIA ERFPHVQRRV GGYNLDALTP
     RNALNNMAHL LVGSEGTLAF TTQLEIKLWP LIRNKVVGVC HFGSFYEAMD AAQHLVKLKP
     IAVELVDKTM IALGRDIAMF RPVIESVVRG DPDALLLVEF AEEDQDENLR RLKQLAQLMG
     DLGFSWNNPP RKWGGVVDVI EPAVQASIAD FRTSGLNVMM SMKQEGKPVS FVEDCAVPLP
     HLADYTDRLN RVFEKYGTRG TMYAHASEGC LHVRPVLNLK LDKDVKAMRA IAEEAFALVR
     EYKGSHSGEH GDGLVRSEFH ESMFGTRLVQ AFGEVKHRFD PANTLNPGKI VDPPKMDDRS
     LFRYPPDYRV NDLKTQLDWS AYPGAGGGFQ GAVEMCNNNG ACRKLEGGVM CPSYRATRNE
     TDVTRGRANT LRLAISGQLG PDALASDEMM DTLKLCVSCK ACRHECPTGV DMAKMKIEVL
     AARAAKHGLT LRDRLVGYLP RYAGLMSTVA PLANLRNHSS LLRALLERVA GISAKRELPS
     WRSDTFNPGE IAVGSANGPE VVLFADTFNR AYERENLDAA LRVLVAGGYR VHLPKPVSGG
     SRPLCCGRTF LSAGLVDQAR EELDRLVATL SPFAERGVPI VGLEPSCLLT LRDELLSLRK
     DDAAKRIGAH ALLLEEFLAR EAKAGRLQLP LKPIATKAVV HGHCHQKSFG AFKPVEEVLR
     LVPGLGVETI ESSCCGMAGA FGYGADTYDV SIQMAEASLL PAVRKAGKDT LVVADGTSCR
     HQIKDGSARE ALHVARVLAM SLDA
//