ID A0A1W9JCH6_9PROT Unreviewed; 616 AA.
AC A0A1W9JCH6;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|ARBA:ARBA00021975, ECO:0000256|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN ORFNames=BVN34_04025 {ECO:0000313|EMBL:OQW69491.1};
OS Proteobacteria bacterium ST_bin12.
OC Bacteria; Pseudomonadota.
OX NCBI_TaxID=1978760 {ECO:0000313|EMBL:OQW69491.1, ECO:0000313|Proteomes:UP000192616};
RN [1] {ECO:0000313|EMBL:OQW69491.1, ECO:0000313|Proteomes:UP000192616}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ST_bin12 {ECO:0000313|EMBL:OQW69491.1};
RX PubMed=28390307; DOI=10.1016/j.watres.2017.03.042;
RA Wang Y., Ma L., Mao Y., Jiang X., Xia Y., Yu K., Li B., Zhang T.;
RT "Comammox in drinking water systems.";
RL Water Res. 116:332-341(2017).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQW69491.1}.
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DR EMBL; MSXP01000004; OQW69491.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1W9JCH6; -.
DR STRING; 1978760.BVN34_04025; -.
DR Proteomes; UP000192616; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03482; MutL_Trans_MutL; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00149};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00149}.
FT DOMAIN 213..331
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 425..572
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
SQ SEQUENCE 616 AA; 67972 MW; A20268FA464EDF28 CRC64;
MPRNLPNAIK LLPDQLINQI AAGEVVERPA SALKELLENS LDAGSSDIQV SLMQGGIKQL
RVADNGKGIP QDDLKMALTR HATSKIFSLE DLEAVASLGF RGEALASIAS VSRTTIVSRA
LETKHAWRIA SDGNEISVIE PAALDFGTVI EVNDLYFNTP ARRKFLKTDS TEFGHSEEAF
TRVALSRPDV SFTLQHNGRV LSRFVSGSPS KRFNEVLGAE FAAESITIVE EAAGLRLWGV
AAKPTFNRNS RDTQYVYVNG RFVRDKLIAH AIRQAYQDVL HHDRHPAFVL FLELDPSLVD
VNVHPSKTEV RFRDGQAIHR FIYHSLNKNL ATPTGLSNAA TASQAAHNPF GHSPFTSQYS
NSPNYPQQQT QINLNANQPS AFYGTLFGGL KHSSDSSLTE NLTPFSGQNF DAQFAQSSDF
PLGFAVAQIH GVYILAQNKL GLVVIDMHAA HERIMYERLK NALDTKQVPM QPLLIPVSFN
ADRLEVATVQ EELSSGLDNL QQLGFEFAIL SPNTLAVRAV PTMLQDADAV TLARNVLKDL
REFGATRALT ERRNELLGTM ACHAAVRANR ILTIPEMNGL LRDMEATERS GMCNHGRPTW
FQVSMSDLDK MFMRGK
//
