ID A0A1W9KNK3_9BURK Unreviewed; 717 AA.
AC A0A1W9KNK3;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
DE AltName: Full=Omega-protein {ECO:0000256|ARBA:ARBA00032877};
DE AltName: Full=Relaxing enzyme {ECO:0000256|ARBA:ARBA00032235};
DE AltName: Full=Swivelase {ECO:0000256|ARBA:ARBA00030003};
DE AltName: Full=Untwisting enzyme {ECO:0000256|ARBA:ARBA00031985};
GN ORFNames=BWK72_20745 {ECO:0000313|EMBL:OQW85737.1};
OS Rhodoferax ferrireducens.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Rhodoferax.
OX NCBI_TaxID=192843 {ECO:0000313|EMBL:OQW85737.1, ECO:0000313|Proteomes:UP000192505};
RN [1] {ECO:0000313|EMBL:OQW85737.1, ECO:0000313|Proteomes:UP000192505}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A7 {ECO:0000313|EMBL:OQW85737.1};
RA Sharrar A.M., Flood B.E., Bailey J.V., Jones D.S., Biddanda B.,
RA Ruberg S.A., Marcus D.N., Dick G.J.;
RT "Novel large sulfur bacteria in the metagenomes of groundwater-fed
RT chemosynthetic microbial mats in the Lake Huron basin.";
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00009446}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQW85737.1}.
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DR EMBL; MTEI01000039; OQW85737.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1W9KNK3; -.
DR Proteomes; UP000192505; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00186; TOP1Ac; 1.
DR CDD; cd03362; TOPRIM_TopoIA_TopoIII; 1.
DR Gene3D; 3.40.50.140; -; 1.
DR Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR InterPro; IPR000380; Topo_IA.
DR InterPro; IPR003601; Topo_IA_2.
DR InterPro; IPR023406; Topo_IA_AS.
DR InterPro; IPR013497; Topo_IA_cen.
DR InterPro; IPR013824; Topo_IA_cen_sub1.
DR InterPro; IPR013825; Topo_IA_cen_sub2.
DR InterPro; IPR013826; Topo_IA_cen_sub3.
DR InterPro; IPR023405; Topo_IA_core_domain.
DR InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR InterPro; IPR005738; TopoIII.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR034144; TOPRIM_TopoIII.
DR NCBIfam; TIGR01056; topB; 1.
DR PANTHER; PTHR11390:SF21; DNA TOPOISOMERASE 3-ALPHA; 1.
DR PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR Pfam; PF01131; Topoisom_bac; 1.
DR Pfam; PF01751; Toprim; 1.
DR PRINTS; PR00417; PRTPISMRASEI.
DR SMART; SM00437; TOP1Ac; 1.
DR SMART; SM00436; TOP1Bc; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR PROSITE; PS00396; TOPOISOMERASE_I_PROK; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:OQW85737.1};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 1..132
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
SQ SEQUENCE 717 AA; 78582 MW; 76F7A363EE9C0C53 CRC64;
MRLFIAEKPS VAKAIAAELG NVTRAEGYLQ CGPDRVTWCF GHILEMAKPE HYGEQYAKWR
AEDLPIIPQA WALLPKDDAK AQLAVIGRLL KDATEVVNAG DPDREGQLLV DEVLDHFKNR
RDVKRFWVSA QDSVSIQRGL AALKNNKDYQ GLKDAALARQ RADWLIGMNF SRAYTLRAQR
GGAQKTVLTV GRVQTPTLAL VVARDREIEA FKPAAYFTLQ AQIEHANGAF RAAWKAKDDQ
AGLDSEGRLV DKTIAEAITK ATTGQAGTLK EYRQEPKADG QPRAYALSDI TLKASNKFGY
SAEDVLKACQ ALYETHKLTS YPRTDCDYLP ESQHADAPRV LAALKHVNPG FAKLIDGADP
TIKSKTWNDA KITAHHGIIP TMHQGDASRL SDIERNIYEL IVRAYLAQFY PAHEYMSTTI
AVDVQSETFT ASGKTVTRNG WRDVYQVEQE EGEAEEDTQA LPPMQQGDGV KCARVDTKAM
KTKPPARFTE GTLGKAMENV HKFVTDPEER KILKEGDGIG TSATRAAIIS ELKRRGFLEP
KGKQIISTTL GRGLIDTLPE KVKSASLTAF YESMLKEIEG GKCAVDTFIE QQAEFIRGQV
AEANSGASTV AGSTGPACPK CGEGHLRRIP RKDGKGHFWG CNRYSEGCSA VYDDKGGKPD
TAAKAAYKCP TCKEGTLRQI AGGAKGKFWG CSRYRDGCRT TFDDKGGKPD IAGKKGA
//
