ID A0A1W9L3J7_9GAMM Unreviewed; 790 AA.
AC A0A1W9L3J7;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:OQW92935.1};
GN ORFNames=BWK79_13790 {ECO:0000313|EMBL:OQW92935.1};
OS Beggiatoa sp. IS2.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Thiotrichales;
OC Thiotrichaceae; Beggiatoa.
OX NCBI_TaxID=1934247 {ECO:0000313|EMBL:OQW92935.1, ECO:0000313|Proteomes:UP000192324};
RN [1] {ECO:0000313|EMBL:OQW92935.1, ECO:0000313|Proteomes:UP000192324}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IS2 {ECO:0000313|EMBL:OQW92935.1};
RA Sharrar A.M., Flood B.E., Bailey J.V., Jones D.S., Biddanda B.,
RA Ruberg S.A., Marcus D.N., Dick G.J.;
RT "Novel large sulfur bacteria in the metagenomes of groundwater-fed
RT chemosynthetic microbial mats in the Lake Huron basin.";
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQW92935.1}.
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DR EMBL; MTEL01000404; OQW92935.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1W9L3J7; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000192324; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 9..192
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 195..293
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 790 AA; 87004 MW; 51C6E1B54D8E0FC8 CRC64;
MSENFHVRKV AVLGAGVMGA QIANHLSNAD VPVVLFELPA KGDDPYADVN RFIQGLRKMQ
PNPSAKPERI DALVPAIYTT DMEKLRDCDF VLEVIAERVD WKYDLYSKVV PYLSPNAILA
TNTSGLSIDL LAEKLPEKMK SRFCGVHFFN PPRYMPLVEL IPGSKTDPSV LDNLETFLVK
TLGKSVVRAK DTPNFVGNRI GVFSIVATMC QAARLGIPFD VVDDLTGSSL GRPKSATFRT
ADVVGLDTLA HILDACLQVL KTDPWQEFYV TPPWLKGLID KGALGQKTKA GVFRKEDGKI
MVLDTDSGNY RKSGGKADAE VAGIMRIRDQ AKRFKALRES KHPQAEFVWA IQRETFHYAA
VMLGEIANSA RDIDMAMRWG YGWKQGPFEI WQEAGWKQIA QWIEEDMAAG KTMTKAPLPA
WVKQVEAAHT PQGSWSAIDN AYRPRSALPV YKRQYFPEQV LGEAAPGTGK TVYSNDGVRL
WHLDDAPDIG IVSIQSKMHA VGEEVLDGML AAIDIAEKQF AGLVVWDAKA PFSVGANLAQ
ILPVILANNF NMVGRIIEKF QAMTSRLRYS LIPTVAAVQG LALGGGCEIL LHCDRVVAAL
ESYIGLVEVG VGVIPAGGGS KEAALRASQR SVDGKVFPFL KEFYTNIAMA KVSMSAQEAQ
KMGWLRDSDI IVFNVNEILY IAIQQARAMA ESAYRPPVPP KIKVAGRTGI ATIKSQLVNM
RDGNFISEHD YYIGSRLAEI VCGGDVEAGS EVDECILLKL EREVFVDLLH QKKTMDRIGF
MLETNKPLRN
//
