ID A0A1W9P4W7_9BACT Unreviewed; 1092 AA.
AC A0A1W9P4W7;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Tricorn protease homolog {ECO:0000256|PIRNR:PIRNR036421};
DE EC=3.4.21.- {ECO:0000256|PIRNR:PIRNR036421};
GN ORFNames=B5M54_06865 {ECO:0000313|EMBL:OQX53424.1};
OS Candidatus Aminicenantes bacterium 4484_214.
OC Bacteria; Candidatus Aminicenantes.
OX NCBI_TaxID=1968529 {ECO:0000313|EMBL:OQX53424.1, ECO:0000313|Proteomes:UP000192734};
RN [1] {ECO:0000313|Proteomes:UP000192734}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Dombrowski N., Seitz K., Teske A., Baker B.;
RT "Novel pathways for hydrocarbon cycling and metabolic interdependencies in
RT hydrothermal sediment communities.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Degrades oligopeptides. {ECO:0000256|PIRNR:PIRNR036421}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|PIRNR:PIRNR036421}.
CC -!- SIMILARITY: Belongs to the peptidase S41B family.
CC {ECO:0000256|ARBA:ARBA00008524, ECO:0000256|PIRNR:PIRNR036421}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQX53424.1}.
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DR EMBL; MZGL01000038; OQX53424.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1W9P4W7; -.
DR Proteomes; UP000192734; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-UniRule.
DR CDD; cd07562; Peptidase_S41_TRI; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.30.750.44; -; 1.
DR Gene3D; 2.120.10.60; Tricorn protease N-terminal domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR011659; PD40.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR005151; Tail-specific_protease.
DR InterPro; IPR028204; Tricorn_C1.
DR InterPro; IPR029414; Tricorn_PDZ.
DR InterPro; IPR012393; Tricorn_protease.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR43253; TRICORN PROTEASE HOMOLOG 2-RELATED; 1.
DR PANTHER; PTHR43253:SF1; TRICORN PROTEASE HOMOLOG 2-RELATED; 1.
DR Pfam; PF07676; PD40; 3.
DR Pfam; PF03572; Peptidase_S41; 1.
DR Pfam; PF14684; Tricorn_C1; 1.
DR Pfam; PF14685; Tricorn_PDZ; 1.
DR PIRSF; PIRSF036421; Tricorn_protease; 1.
DR SMART; SM00245; TSPc; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF69304; Tricorn protease N-terminal domain; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR036421};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR036421};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PIRNR:PIRNR036421};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825,
KW ECO:0000256|PIRNR:PIRNR036421}.
FT DOMAIN 847..1037
FT /note="Tail specific protease"
FT /evidence="ECO:0000259|SMART:SM00245"
FT REGION 547..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1061..1092
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1061..1084
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 744
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR036421-1"
FT ACT_SITE 968
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR036421-1"
FT ACT_SITE 1026
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR036421-1"
SQ SEQUENCE 1092 AA; 125946 MW; 057124A79253E14A CRC64;
MKKIIGCLVI ILFVLGAFLW AEEARVLRFP DVNRDLIVFV YAGDIWSVPI TGGEARRLTS
HVGLELFPKI SPDGRWIAFS AEYSGTRQVY VMPSTGGRPR QLTYYNDVGA LPPRGGFDYQ
VLDWTPNSRQ ILFRANRTPW GPRMGRYFLI NVEGGLEQPL VIPEAGGGTF SPTGDQIVYT
PISREWRTWK RYQGGRAQDI WIYDLKKNEA QRLTTYPGTD QHPIWYKDKI YFVSDRDLVL
NIYAYDLKTK EIKQITHHTE YDVLWPSGEG GKIVYENGGY IYLLDLETEK YHRVPIEIHF
DNPNLMPYFK NVKDNITRFD LSPQGKQAVF EARGEIFTVP AKEGVTRNLS QTPGVREIFP
TWSPDGRYIA YYSDKTGEYE IYLFDRQTRT TRQLTHDSHI WRFAPLWSPD STKLLFSDKN
QWLQFLDIQS GKITRVDRAR RFEITHYAWS PDSRWIVYTK DGENGQAAVW VYSLETGKPR
QLTDDMYQDF QPVFSTCGQY LFFLSDRTFN LTFSSFEQDY LYTKATKIYA IPLTKDTPPL
FQEKIEEEEI SPTDQGKKKV NKKQPSDKSE AGKKKAVKID FKGINDRIVS FPLPAGNYRW
LEAVEDGVIY LKDGELHHFN LQRKKDEVIL KRVSGVALAA NRKKVLYRSG DVYGIIDLKP
NQKKGAGALN LKDLTLKIYP QKEWRQMFVD GWRIYRDWFY VENMHGVDWE KVRRKYEVLV
PYLGHRADLD YLFGELVGEL NVGHAYVNWG EFERPKRVEG GLLGAEFEAD VQAGRYRIKK
IYRGENWEER TRSPLTEQGV NIKEGDYLIS LNGHEVTLKD NPYKFLENTA GKRISIMVNS
VPKKEGAREY WVKPIRSELQ LFYLDWVRTR REMVDRLSGG RIGYFHVPNT SRDGNRELFK
GMYAFHHKEA LIIDERYNGG GFIPDVMIDL LDRQVLNYWA RRGLTLSQTP GVAHLGPKVM
LINHYSASGG DAFPYYFKKL NLGLLIGTRT WGGLVGLSGN PGLMDGGYLA VPTFGFVDTE
GNWAVEGVGV APDIEVYDRP DLVAKGHDPS LEKAVEVLLE QLKKNPPRRP QKPQPPDRSG
FHEKAKVKVK KK
//
