ID A0A1W9P859_9BACT Unreviewed; 1207 AA.
AC A0A1W9P859;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=DNA polymerase III subunit alpha {ECO:0000256|ARBA:ARBA00019114};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=B5M48_00550 {ECO:0000313|EMBL:OQX54588.1};
OS Candidatus Omnitrophica bacterium 4484_213.
OC Bacteria; Candidatus Omnitrophota.
OX NCBI_TaxID=1968528 {ECO:0000313|EMBL:OQX54588.1, ECO:0000313|Proteomes:UP000192577};
RN [1] {ECO:0000313|Proteomes:UP000192577}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Dombrowski N., Seitz K., Teske A., Baker B.;
RT "Novel pathways for hydrocarbon cycling and metabolic interdependencies in
RT hydrothermal sediment communities.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQX54588.1}.
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DR EMBL; MZGK01000002; OQX54588.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1W9P859; -.
DR STRING; 1968528.B5M48_00550; -.
DR Proteomes; UP000192577; Unassembled WGS sequence.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd12113; PHP_PolIIIA_DnaE3; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 28..95
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1207 AA; 137580 MW; 7A51BCF959398A1B CRC64;
MLKAVLHILG TSNQTNTSLP NVTHANFAHL HVHSQYSLLD GACKLPDLIK RSIELKFPAI
AITDHGNMFG AIEFYQEAMK QGIKPIIGYE AYLAPESRFN RDPEVEKRGR KHLTLLVKDL
KGYKNLVKLA TAAYLEGFYY KPRIDKEILS QYSEGLIGLS GCLHGEIPNY IINDQIDKAK
KAIIDFQDIF GKDNFYLELQ DQLIPEQKKV NRELIKIAKE MNIELVATND VHYLHKSDSY
NHEILLCLQT QTTLDDPKRM RFSTNKFYLK SEEEMKELFS EIPSALTNTL KVVNKCNLEL
DFSKKYMPVF SPPQGLTDKE YLKELCQQRL KERFKEVHPE FSDTSVGGAS KAQFNGINPV
KSAKGAVRPS ELFSRVNEEV IQRMNQELKI IEESGYASYF LIVQDFINFA KKNNIAVGPG
RGSVAGSLVA YILGITDINP LKYNLLFERF LNYERITMPD IDIDFCYQRR DEVIDYVTQK
YSKENVSQII TFGTMAAHGV IRDVGRVMGM PYSEVDRIAK LVPLTLNITI QEALYQEPRL
KELYEQDKQI KRLLDISKSL EGLTRHASTH AAGVVISKQP LSDIVPLFKS PDGKIATQYS
MFSLEKIGLL KMDFLGLRTL TVISKTIENI RRFSGKEISV ESIPLDDKKT YHLLCKGKST
GVFQLESAGM QDLLKRIEPQ NFEDIIAILA LHRPGPLGSG MINDFVQRKH NPKLIKYDHP
KLKPILKETY GIILYQEQIM QIAHILAGFS LTQADLLRRA ISKKIPEVIE QQKESFVEGC
LKNGIRRRVA EKVFNLIEYF SGYGFNKSHS AAYALISYRT AYLKANCPLQ FMAALLTSEE
DNTDKIADYV EECRKMGIRI LPPDVQQSFA EFTVEKDSIR FGLLAVKNVG RGAIDSIIKA
RTRKNFFSLE DFCQRVDLRL VNKKVIESLI KCGAFDCFNL PRAQLIVDLE GSLQRANRLQ
RDKSRGQLSL LDNLSYFEPR KEEKKITIKE WPRNQLLAFE KELLGFYFSG HPLAEYEQVL
KRYSVSFTEL NNYSENEEVL VGGVVTKIKQ IVTKRGEKMA FFNLEISNGA IEIILFPKVF
NKVSNYVKID APIFVEGKIS LRNNERKIIA EKLIPIEQIS QKYTASISLN LEADSDENLL
RQIKRLVSAH QGDVPLYLIF SSPRGKHTIR SSLTAKCTES FLLQLEQLIG KERVTVEVNP
VRKGGAF
//