ID   A0A1W9PKH9_9HELI        Unreviewed;      1200 AA.
AC   A0A1W9PKH9;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   13-SEP-2023, entry version 18.
DE   RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN   ORFNames=B5M52_04585 {ECO:0000313|EMBL:OQX58839.1};
OS   Helicobacteraceae bacterium 4484_230.
OC   Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae.
OX   NCBI_TaxID=1968531 {ECO:0000313|EMBL:OQX58839.1, ECO:0000313|Proteomes:UP000192641};
RN   [1] {ECO:0000313|Proteomes:UP000192641}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Dombrowski N., Seitz K., Teske A., Baker B.;
RT   "Novel pathways for hydrocarbon cycling and metabolic interdependencies in
RT   hydrothermal sediment communities.";
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OQX58839.1}.
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DR   EMBL; MZGN01000053; OQX58839.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1W9PKH9; -.
DR   Proteomes; UP000192641; Unassembled WGS sequence.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd04485; DnaE_OBF; 1.
DR   CDD; cd12113; PHP_PolIIIA_DnaE3; 1.
DR   Gene3D; 1.10.150.870; -; 1.
DR   Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR   InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR   InterPro; IPR040982; DNA_pol3_finger.
DR   InterPro; IPR004805; DnaE2/DnaE/PolC.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   NCBIfam; TIGR00594; polc; 1.
DR   PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF17657; DNA_pol3_finger; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF160975; AF1531-like; 1.
DR   SUPFAM; SSF89550; PHP domain-like; 1.
PE   4: Predicted;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          7..74
FT                   /note="Polymerase/histidinol phosphatase N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00481"
SQ   SEQUENCE   1200 AA;  136868 MW;  E1E11DAD8F0BF759 CRC64;
     MGALPFTHLH LHTEYSLLDG ANKISNLVER VKELGMKSVA MTDHGNMFGT IDFYQQMKSA
     GIKPIIGMEG YIHNGEEIGD KSTRQRFHIC LYAKNQKGYE NLMYLSSKAY VDGFYYYPRI
     NKKLLKEHTE GLICSSACLQ GEVNWHLNLK NERNVKNGAE GYEGAKRVAL EYKEMFGDDF
     YLEIMRHGIG DQLYIDDQIL RLSKETGIKL VATNDTHYTY PGDAQYHEAF MCIGMNKLYD
     DPNRMRHSVH EFYLKSPQEM ARLFADIPEA LEHTQEIVDK CELELKLGNP TPPNFKFTRE
     YAAKDGLNIE HEDDAPLEEG ADGDAGKKWL SAADKNDAEY FIYRCKKGLQ ERLKYVPEER
     HEEYRQRLEY EMDIINSMKF PGYMLIVWDF VKVAKEMGIA VGPGRGSAAG SLVAYSLEIT
     DIDPMKYDLL FERFLNPERV SMPDIDMDFM QARRGEIIDY VVEKYGRNQV AQIITFGSLL
     AKGVIRDVAR VLDMPLSQAD KMAKLIPDEL GITLNGKMKN GELKPGAFQK EPKIRELIES
     DPSAERVWEF SKKLEGLKRN AGMHAAGVVI SNDELWHKTP IYKPSGEETF VTQYSLNYLE
     DVDLIKFDFL GLKTLDVIDS ALKLIKLRHS IEVDWHDTDV NDPGVYEVIQ SGATVGMFQI
     ESSGMQDLNK RLKPSNFEDL VAVLALYRPG PMESGMLDDF IERKHGRQEI TYTFKEMEPI
     LEPTYGVIVY QEQVMQIVQT IGGFSLGYSD IIRRAMGKKK DMAAYNAEFS EGAQKQGYDY
     KTASDLFALI EKFAGYGFNK SHSAAYAMVT FQTAWLKTYY PKEFMAALLT SERDNTDKVV
     KYIDEAKRMN IELVPPHINK SHMEFSPTSE GDSDYILFGL AAIKGVGTSA VQSILEVREE
     GEFKDLQDFV NRIEPQKVNK KVLESIIKAG GFDCFGFSRK ALLDQIEVLI DTAKNSSTLR
     KEAQFSLFGD DAEVMTVDLV LKNEPEYDLK EILEFEKETL GFYVSGHPLD DYREEIEGLN
     YTLSSEIENI ADGSTAIFIG KVEEITKKIS KKGNQFGIVE LMDFHGDIEM MLFSDKLEKL
     EEMDLQKPIA FKVKVTQHHD FGARISVMKI FTLKEVKKEA KKVDTKIVEQ PPEPLMLKLH
     LDKNTELLEE LYRLARSHPG KRPLKLMIVS RLQNIIIDSA IRVDGRIIKE LEKFTDVDVA
//