ID A0A1W9QPD3_9BACT Unreviewed; 447 AA.
AC A0A1W9QPD3;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 13-SEP-2023, entry version 17.
DE RecName: Full=3-hydroxy-3-methylglutaryl coenzyme A reductase {ECO:0000256|RuleBase:RU361219};
DE Short=HMG-CoA reductase {ECO:0000256|RuleBase:RU361219};
DE EC=1.1.1.88 {ECO:0000256|RuleBase:RU361219};
GN ORFNames=B6D61_13765 {ECO:0000313|EMBL:OQX72413.1};
OS Bacteroidetes bacterium 4484_249.
OC Bacteria; Bacteroidota.
OX NCBI_TaxID=1970778 {ECO:0000313|EMBL:OQX72413.1, ECO:0000313|Proteomes:UP000192581};
RN [1] {ECO:0000313|Proteomes:UP000192581}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Dombrowski N., Seitz K., Teske A., Baker B.;
RT "Novel pathways for hydrocarbon cycling and metabolic interdependencies in
RT hydrothermal sediment communities.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(R)-mevalonate + CoA + 2 NAD(+) = (3S)-hydroxy-3-
CC methylglutaryl-CoA + 2 H(+) + 2 NADH; Xref=Rhea:RHEA:14833,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:36464, ChEBI:CHEBI:43074,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.88;
CC Evidence={ECO:0000256|RuleBase:RU361219};
CC -!- PATHWAY: Metabolic intermediate metabolism; (R)-mevalonate degradation;
CC (S)-3-hydroxy-3-methylglutaryl-CoA from (R)-mevalonate: step 1/1.
CC {ECO:0000256|RuleBase:RU361219}.
CC -!- SIMILARITY: Belongs to the HMG-CoA reductase family.
CC {ECO:0000256|ARBA:ARBA00007661, ECO:0000256|RuleBase:RU361219}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQX72413.1}.
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DR EMBL; NATE01000332; OQX72413.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1W9QPD3; -.
DR UniPathway; UPA00257; UER00367.
DR Proteomes; UP000192581; Unassembled WGS sequence.
DR GO; GO:0140643; F:hydroxymethylglutaryl-CoA reductase (NADH) activity; IEA:UniProtKB-EC.
DR GO; GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:InterPro.
DR GO; GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.
DR CDD; cd00644; HMG-CoA_reductase_classII; 1.
DR InterPro; IPR002202; HMG_CoA_Rdtase.
DR InterPro; IPR004553; HMG_CoA_Rdtase_bac-typ.
DR InterPro; IPR023074; HMG_CoA_Rdtase_cat_sf.
DR InterPro; IPR009023; HMG_CoA_Rdtase_NAD(P)-bd_sf.
DR InterPro; IPR009029; HMG_CoA_Rdtase_sub-bd_dom_sf.
DR NCBIfam; TIGR00532; HMG_CoA_R_NAD; 1.
DR PANTHER; PTHR10572; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR PANTHER; PTHR10572:SF24; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR Pfam; PF00368; HMG-CoA_red; 1.
DR PRINTS; PR00071; HMGCOARDTASE.
DR SUPFAM; SSF55035; NAD-binding domain of HMG-CoA reductase; 1.
DR SUPFAM; SSF56542; Substrate-binding domain of HMG-CoA reductase; 1.
DR PROSITE; PS50065; HMG_COA_REDUCTASE_4; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|RuleBase:RU361219};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU361219}.
SQ SEQUENCE 447 AA; 49770 MW; 6CC130CD325BB3E5 CRC64;
MSSNKILSGF SKLAKDEKIK MVAGRFGNAG EIIRELKSYL HDDPEKQRLF DEFSENTISN
FYFPFAIAPN FLINEKMYMV PMVIEESSVV AAASNGAKYW APKGGFNAEV ISTTKVGQVH
FIWQGEVEKL QALFPMLKDD LISKTKHITA NMETRGGGIL DIELVDMTDE MENYFQLKAS
FDTRNAMGAN FINSCLEEFA VILKDHFAKI EYYTGQEKTC CVIMSIMSNY TPECLVKTEV
ECSVDCLKHA EDVTDPDSFV RKFEKAVRIA QIDPYRATTH NKGIFNGIDA VALATGNDFR
AIEACGHAYA ARDGRYRGLT DVDISNDKFK YSLTIPLSLG TVGGLTSLHP LAKFSMQLLG
NPSAVELMMI AASVGLANNF GAIKSLVTRG IQVGHMKMHL LNILNSIKVN EKEKDFAVAH
FANQKVSYHS VNKFVTDLRK EHIEKVG
//
