ID A0A1W9R7Y2_9BACT Unreviewed; 460 AA.
AC A0A1W9R7Y2;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=mannose-1-phosphate guanylyltransferase {ECO:0000256|ARBA:ARBA00012387};
DE EC=2.7.7.13 {ECO:0000256|ARBA:ARBA00012387};
GN ORFNames=B6D56_04625 {ECO:0000313|EMBL:OQX80616.1};
OS Candidatus Omnitrophica bacterium 4484_70.1.
OC Bacteria; Candidatus Omnitrophota.
OX NCBI_TaxID=1970782 {ECO:0000313|EMBL:OQX80616.1, ECO:0000313|Proteomes:UP000192269};
RN [1] {ECO:0000313|Proteomes:UP000192269}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Dombrowski N., Seitz K., Teske A., Baker B.;
RT "Novel pathways for hydrocarbon cycling and metabolic interdependencies in
RT hydrothermal sediment communities.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-
CC alpha-D-mannose; Xref=Rhea:RHEA:15229, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57527,
CC ChEBI:CHEBI:58409; EC=2.7.7.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001083};
CC -!- SIMILARITY: Belongs to the mannose-6-phosphate isomerase type 2 family.
CC {ECO:0000256|ARBA:ARBA00006115, ECO:0000256|RuleBase:RU004190}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQX80616.1}.
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DR EMBL; NATL01000020; OQX80616.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1W9R7Y2; -.
DR Proteomes; UP000192269; Unassembled WGS sequence.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase (GTP) activity; IEA:UniProtKB-EC.
DR GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR CDD; cd02213; cupin_PMI_typeII_C; 1.
DR CDD; cd02509; GDP-M1P_Guanylyltransferase; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR006375; Man1P_GuaTrfase/Man6P_Isoase.
DR InterPro; IPR001538; Man6P_isomerase-2_C.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin_sf.
DR NCBIfam; TIGR01479; GMP_PMI; 1.
DR PANTHER; PTHR46390; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR PANTHER; PTHR46390:SF1; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR Pfam; PF01050; MannoseP_isomer; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF51182; RmlC-like cupins; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Isomerase {ECO:0000313|EMBL:OQX80616.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000313|EMBL:OQX80616.1}; Transferase {ECO:0000313|EMBL:OQX80616.1}.
FT DOMAIN 2..278
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
FT DOMAIN 309..458
FT /note="Mannose-6-phosphate isomerase type II C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01050"
SQ SEQUENCE 460 AA; 53546 MW; FC9493C33AE885F1 CRC64;
MKALILAGGK GKRLFPLSRQ NYPKQFVELI KGRSLFQLTL TRLLGYFAPG DIFILSQQDY
KFHIINQIEF LNLSSKEKRT LRNNLILEPL SRNTAPCSLL ALKYLEEKRK GREEVIFLFP
SDHIIEPKEK FIQTLPNAKR LADKGYIVTF GVLPDEAKSG YGYVLVEDKC EGGYLVKRFV
EKPSLRRAKE LIKKGAFWNA GIFCFKKSVF LEELEKYAPA IFNYYKKGYS QIVENFSAFP
EVSIDYAVMQ KTRKAALVEF NLRWSDLGSW DSFLKFFSSS DSSFSIGKAE FINSRKCYFF
SPKRLTIGVG VDNLMVVDTP DCILVMKRGK SEKISDVVKM LEERGSELVK ESTIVYRPWG
YYKVLEVGEN YKVKEIGVYP HKYISYQRHK FRSEHWNVVE GKAKITLKEK EFIIKRNQSL
FVPRMTKHRV YNPTNRLLRI IETQIGTYLG EDDIERFDTY
//