ID   A0A1W9S1N2_9BACT        Unreviewed;       439 AA.
AC   A0A1W9S1N2;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   22-FEB-2023, entry version 18.
DE   SubName: Full=Indolepyruvate ferredoxin oxidoreductase subunit alpha {ECO:0000313|EMBL:OQX90713.1};
DE   Flags: Fragment;
GN   ORFNames=B6D57_02200 {ECO:0000313|EMBL:OQX90713.1};
OS   Candidatus Coatesbacteria bacterium 4484_99.
OC   Bacteria; Candidatus Coatesbacteria.
OX   NCBI_TaxID=1970774 {ECO:0000313|EMBL:OQX90713.1, ECO:0000313|Proteomes:UP000192611};
RN   [1] {ECO:0000313|Proteomes:UP000192611}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Dombrowski N., Seitz K., Teske A., Baker B.;
RT   "Novel pathways for hydrocarbon cycling and metabolic interdependencies in
RT   hydrothermal sediment communities.";
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OQX90713.1}.
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DR   EMBL; NATQ01000032; OQX90713.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1W9S1N2; -.
DR   Proteomes; UP000192611; Unassembled WGS sequence.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   CDD; cd02008; TPP_IOR_alpha; 1.
DR   CDD; cd07034; TPP_PYR_PFOR_IOR-alpha_like; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   InterPro; IPR045025; HACL1-like.
DR   InterPro; IPR002880; Pyrv_Fd/Flavodoxin_OxRdtase_N.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   PANTHER; PTHR43710; 2-HYDROXYACYL-COA LYASE; 1.
DR   PANTHER; PTHR43710:SF5; INDOLEPYRUVATE FERREDOXIN OXIDOREDUCTASE ALPHA SUBUNIT; 1.
DR   Pfam; PF01855; POR_N; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR   SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE   4: Predicted;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW   Electron transport {ECO:0000256|ARBA:ARBA00022982};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022485};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Pyruvate {ECO:0000313|EMBL:OQX90713.1};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          15..178
FT                   /note="Pyruvate flavodoxin/ferredoxin oxidoreductase
FT                   pyrimidine binding"
FT                   /evidence="ECO:0000259|Pfam:PF01855"
FT   DOMAIN          363..439
FT                   /note="Thiamine pyrophosphate enzyme TPP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02775"
FT   NON_TER         439
FT                   /evidence="ECO:0000313|EMBL:OQX90713.1"
SQ   SEQUENCE   439 AA;  48283 MW;  12AF41F598C34110 CRC64;
     MDKELLSGNE AIARGAYEAG VQVATAYPGT PSTEILEAIG KRYKGDIYCE WSVNEKVAVE
     VAMGASFAGA RALSAMKHVG LNVAADPVFS LSYIGATGGI IIVTADDPYM HSSQNEQDNR
     NYGRHAYIPV LEPSDSQECK DYVVWGIKIS EEFDTPVLLR LTTRISHSKS IVELGERVES
     PEPDYVKELS RRVILPAFAR KLRLKVIKRL KKLAEFAEIF PENRVEMNDT KIGIITSGIS
     YNYVKEVAPQ ASVLKLGMVY PLPPYMIKKF AESVDDLYVV EELDPFIETE VNRLGIFPKG
     KSYVPLYYEL NPERVECALK GEPDPVPEMP EDAPLRPPVL CPGCPHANVF YHLHRMKMIV
     TGDIGCYTLG ALPPLNAMDT CVCMGASVTN AIGIEKALGR ENAKKIVAVI GDSTFIHSGI
     TGLIDAVYNK GHSNIIILD
//