ID A0A1W9T6Y3_9BACT Unreviewed; 305 AA.
AC A0A1W9T6Y3;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 22-FEB-2023, entry version 14.
DE RecName: Full=prephenate dehydratase {ECO:0000256|ARBA:ARBA00013147};
DE EC=4.2.1.51 {ECO:0000256|ARBA:ARBA00013147};
GN ORFNames=B6I20_02310 {ECO:0000313|EMBL:OQY04824.1};
OS Bacteroidetes bacterium 4572_117.
OC Bacteria; Bacteroidota.
OX NCBI_TaxID=1971632 {ECO:0000313|EMBL:OQY04824.1, ECO:0000313|Proteomes:UP000192701};
RN [1] {ECO:0000313|Proteomes:UP000192701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Dombrowski N., Seitz K., Teske A., Baker B.;
RT "Novel pathways for hydrocarbon cycling and metabolic interdependencies in
RT hydrothermal sediment communities.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O;
CC Xref=Rhea:RHEA:21648, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:18005, ChEBI:CHEBI:29934; EC=4.2.1.51;
CC Evidence={ECO:0000256|ARBA:ARBA00000913};
CC -!- PATHWAY: Amino-acid biosynthesis; L-phenylalanine biosynthesis;
CC phenylpyruvate from prephenate: step 1/1.
CC {ECO:0000256|ARBA:ARBA00004741}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQY04824.1}.
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DR EMBL; NBLH01000023; OQY04824.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1W9T6Y3; -.
DR UniPathway; UPA00121; UER00345.
DR Proteomes; UP000192701; Unassembled WGS sequence.
DR GO; GO:0004106; F:chorismate mutase activity; IEA:InterPro.
DR GO; GO:0004664; F:prephenate dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0009094; P:L-phenylalanine biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd04905; ACT_CM-PDT; 1.
DR CDD; cd13631; PBP2_Ct-PDT_like; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR008242; Chor_mutase/pphenate_deHydtase.
DR InterPro; IPR001086; Preph_deHydtase.
DR PANTHER; PTHR21022; PREPHENATE DEHYDRATASE P PROTEIN; 1.
DR PANTHER; PTHR21022:SF19; PREPHENATE DEHYDRATASE-RELATED; 1.
DR Pfam; PF00800; PDT; 1.
DR PIRSF; PIRSF001500; Chor_mut_pdt_Ppr; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51171; PREPHENATE_DEHYDR_3; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Phenylalanine biosynthesis {ECO:0000256|ARBA:ARBA00023222}.
FT DOMAIN 8..185
FT /note="Prephenate dehydratase"
FT /evidence="ECO:0000259|PROSITE:PS51171"
FT DOMAIN 203..279
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
FT SITE 178
FT /note="Essential for prephenate dehydratase activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR001500-2"
SQ SEQUENCE 305 AA; 34362 MW; 6D0DE1D3B17ADF4C CRC64;
MNNNSKLKIA IQGGAGSFHE ISSIFHFGQD IENIAFDSFA KLVDAIETNK LHAGLMAIEN
TVAGSLLPNY ALLKDKDIQI IGEILLRIEQ NLMALPNQSI EDIKEVHSHP MALQQCAKFF
KQYPHIKLIE SDDTANSAKR IAEQNLKNIA AIASTRAADL FGLQVLNKSI ETNKRNFTRF
LILTNNNQLK AEQTIQGNLN KASISFSLPH EQGSLSSILS MFAFYKINLT KIQSIPIIGK
EWEYHFIVDF TFNDRKVFGQ SLDAIKPLIS ELQIYGIYEK AEKYYHSNKL DTNKNKLMEV
DSLQG
//
