ID   A0A1W9U576_9CHLR        Unreviewed;       480 AA.
AC   A0A1W9U576;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   24-JAN-2024, entry version 17.
DE   RecName: Full=L-lactate permease {ECO:0000256|RuleBase:RU365092};
GN   ORFNames=B6I35_15790 {ECO:0000313|EMBL:OQY16494.1};
OS   Anaerolineaceae bacterium 4572_32.2.
OC   Bacteria; Chloroflexota; Anaerolineae; Anaerolineales; Anaerolineaceae.
OX   NCBI_TaxID=1971624 {ECO:0000313|EMBL:OQY16494.1, ECO:0000313|Proteomes:UP000192785};
RN   [1] {ECO:0000313|Proteomes:UP000192785}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Dombrowski N., Seitz K., Teske A., Baker B.;
RT   "Novel pathways for hydrocarbon cycling and metabolic interdependencies in
RT   hydrothermal sediment communities.";
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Uptake of L-lactate across the membrane. Can also transport
CC       D-lactate and glycolate. {ECO:0000256|RuleBase:RU365092}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU365092};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU365092}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the lactate permease family.
CC       {ECO:0000256|ARBA:ARBA00010100, ECO:0000256|RuleBase:RU365092}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OQY16494.1}.
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DR   EMBL; NBLW01000274; OQY16494.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1W9U576; -.
DR   STRING; 1971624.B6I35_15790; -.
DR   Proteomes; UP000192785; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015129; F:lactate transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   InterPro; IPR003804; Lactate_perm.
DR   PANTHER; PTHR30003; L-LACTATE PERMEASE; 1.
DR   PANTHER; PTHR30003:SF2; L-LACTATE PERMEASE; 1.
DR   Pfam; PF02652; Lactate_perm; 2.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|RuleBase:RU365092};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365092};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU365092};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU365092};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365092}.
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        38..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        65..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        107..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        183..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        216..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        239..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        272..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        298..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        335..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        373..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        397..420
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        456..477
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
SQ   SEQUENCE   480 AA;  49017 MW;  E4BBD90135AFE9F1 CRC64;
     MQSPLSTLLD WLLALLPILA VLVLMLRFRW GGAQAGAVGW ATALLVAALR FGAGWQVLAC
     AQLKGLLLTL FVLYIIWTAL LFYRVTDEAG VVQSIGAGLP RLTPDRGLQA LLLGWVFSAF
     LQGMGGFGVP VAVVAPLLTG LGFPAVAAVV IPSVGHAWAV TFGSLGSSFY ALMAATGRGG
     AELAPWSAAL LGLACLGCGA ATLWAAGGWR TLRSNLTAWL IIGVTMAVTQ FLVVTHGLWA
     IGGMMGGLAG LAVGVMWARW RAGGLIGEDR PTAGMPLGWA LLPYILLVAI VLTAQVPFMK
     AVLTYASLVT YLLFQRRGCY KPGAAGRIAR SVAKKAVRSS LGTAAMVGMA VTMEHAGMTH
     LLADGIAQAA GRAFPLAAPF IGVLGAFMTG SNTNSNVVFG GLQQGVAMLL GVSPLIILAA
     QTAGGAIGSA FAPAKIIVGC STVGSGEEES AVLKAVMRYG LAIVAGLALA TGAAVYLGGS
//