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Database: UniProt
Entry: A0A1W9ZQV1_9MYCO
LinkDB: A0A1W9ZQV1_9MYCO
Original site: A0A1W9ZQV1_9MYCO 
ID   A0A1W9ZQV1_9MYCO        Unreviewed;       316 AA.
AC   A0A1W9ZQV1;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   13-FEB-2019, entry version 9.
DE   RecName: Full=Prephenate dehydratase {ECO:0000256|RuleBase:RU361254};
DE            Short=PDT {ECO:0000256|RuleBase:RU361254};
DE            EC=4.2.1.51 {ECO:0000256|RuleBase:RU361254};
GN   Name=pheA {ECO:0000256|RuleBase:RU361254};
GN   ORFNames=BST14_03380 {ECO:0000313|EMBL:ORA20171.1};
OS   Mycobacterium arosiense ATCC BAA-1401 = DSM 45069.
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=1265311 {ECO:0000313|EMBL:ORA20171.1, ECO:0000313|Proteomes:UP000192707};
RN   [1] {ECO:0000313|EMBL:ORA20171.1, ECO:0000313|Proteomes:UP000192707}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 45069 {ECO:0000313|EMBL:ORA20171.1,
RC   ECO:0000313|Proteomes:UP000192707};
RA   Tortoli E., Trovato A., Cirillo D.M.;
RT   "The new phylogeny of genus Mycobacterium.";
RL   Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O;
CC         Xref=Rhea:RHEA:21648, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:18005, ChEBI:CHEBI:29934;
CC         EC=4.2.1.51; Evidence={ECO:0000256|RuleBase:RU361254};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-phenylalanine biosynthesis;
CC       phenylpyruvate from prephenate: step 1/1.
CC       {ECO:0000256|RuleBase:RU361254}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ORA20171.1}.
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DR   EMBL; MVHG01000004; ORA20171.1; -; Genomic_DNA.
DR   BioCyc; GCF_002086125:BST14_RS03355-MONOMER; -.
DR   UniPathway; UPA00121; UER00345.
DR   Proteomes; UP000192707; Unassembled WGS sequence.
DR   GO; GO:0004106; F:chorismate mutase activity; IEA:InterPro.
DR   GO; GO:0004664; F:prephenate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009094; P:L-phenylalanine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR008242; Chor_mutase/pphenate_deHydtase.
DR   InterPro; IPR001086; Preph_deHydtase.
DR   InterPro; IPR018528; Preph_deHydtase_CS.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00800; PDT; 1.
DR   PIRSF; PIRSF001500; Chor_mut_pdt_Ppr; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS00858; PREPHENATE_DEHYDR_2; 1.
DR   PROSITE; PS51171; PREPHENATE_DEHYDR_3; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Aromatic amino acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Complete proteome {ECO:0000313|Proteomes:UP000192707};
KW   Lyase {ECO:0000256|RuleBase:RU361254};
KW   Phenylalanine biosynthesis {ECO:0000256|RuleBase:RU361254}.
FT   DOMAIN        3    189       Prephenate dehydratase.
FT                                {ECO:0000259|PROSITE:PS51171}.
FT   DOMAIN      203    280       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   SITE        182    182       Essential for prephenate dehydratase
FT                                activity. {ECO:0000256|PIRSR:PIRSR001500-
FT                                2}.
SQ   SEQUENCE   316 AA;  32780 MW;  CFC6FBD1A8591121 CRC64;
     MARIAYLGPE GTFTEAALQQ ITAARLIPDE GPAGVQPSPV ESASAALDAV RDGAADYACV
     PIENSIDGSV TPTLDSLAIG SPLQVFAETT LDVAFSIVVK PGRSAADVRT LAAFGVAAAQ
     VRQWVAANLP DAALRPAYSN AEAAQQVAQG RVDAAVTSPL AATHWGLATL AEGVIDESNA
     RTRFLLVGRP APPPARTGAD RTSVVLRIDN APGALLAALA EFAVRGIDLT RIESRPTRTG
     LGTYRFFADC VGHIDDDAVA EALKALHRRC ADVRYLGSWP TGSPAGGLPP SAAEAARWLQ
     QLRDGKGDES AEGAQR
//
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