ID A0A1X0CMX9_9MYCO Unreviewed; 370 AA.
AC A0A1X0CMX9;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Type III polyketide synthase {ECO:0000313|EMBL:ORA61484.1};
GN ORFNames=BST26_21275 {ECO:0000313|EMBL:ORA61484.1};
OS Mycolicibacterium insubricum.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=444597 {ECO:0000313|EMBL:ORA61484.1, ECO:0000313|Proteomes:UP000192801};
RN [1] {ECO:0000313|EMBL:ORA61484.1, ECO:0000313|Proteomes:UP000192801}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45130 {ECO:0000313|EMBL:ORA61484.1,
RC ECO:0000313|Proteomes:UP000192801};
RA Tortoli E., Trovato A., Cirillo D.M.;
RT "The new phylogeny of genus Mycobacterium.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005194}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC synthases family. {ECO:0000256|ARBA:ARBA00005531}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORA61484.1}.
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DR EMBL; MVHS01000102; ORA61484.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X0CMX9; -.
DR STRING; 444597.BST26_21275; -.
DR UniPathway; UPA00094; -.
DR Proteomes; UP000192801; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00831; CHS_like; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR InterPro; IPR011141; Polyketide_synthase_type-III.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11877; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR PANTHER; PTHR11877:SF46; TYPE III POLYKETIDE SYNTHASE A; 1.
DR Pfam; PF02797; Chal_sti_synt_C; 1.
DR Pfam; PF00195; Chal_sti_synt_N; 1.
DR PIRSF; PIRSF000451; PKS_III; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
PE 3: Inferred from homology;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000192801}.
FT DOMAIN 10..213
FT /note="Chalcone/stilbene synthase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00195"
FT DOMAIN 239..366
FT /note="Chalcone/stilbene synthase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02797"
FT ACT_SITE 152
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000451-1"
SQ SEQUENCE 370 AA; 38432 MW; CFA48CC492BAA215 CRC64;
MPPAPPSSIA VIESIATGAP ARVVDQNDAA VRTAALFADP TQRERVTRIH RNTMVNTRHL
AVDPIDDEFT GVRTTPANIR ERMNLFYAHA APLAVDVAGR AVAAVPGAAA DIGLLVFVTS
TGFIAPGVDV AVIRGLGLSP TVSRLVVNFM GCAAAMNGIR TASDYVRAHP DRKALLVCLE
MSSVNAAFAD DVNDIITHSL FGDGAAAVVI GAGAVQHPLS PGKVVIRDTF THLFDDAADG
IVLGVNHNGI TCELSPDLPD YILAGVRPAV TAALAPHDLG IADIDAWAIH PGGPKIISES
VRSLGVAPEV AAASWDVLAG YGNLLSVALL FVLEHLVAQE DADSTISTGV AFSFGPGVAL
EGMLFDIIRR
//
