ID A0A1X0CYD5_9MYCO Unreviewed; 625 AA.
AC A0A1X0CYD5;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Alkyl/aryl-sulfatase {ECO:0000313|EMBL:ORA65181.1};
DE SubName: Full=MBL fold hydrolase {ECO:0000313|EMBL:BBZ64949.1};
GN ORFNames=BST26_19030 {ECO:0000313|EMBL:ORA65181.1}, MINS_03780
GN {ECO:0000313|EMBL:BBZ64949.1};
OS Mycolicibacterium insubricum.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=444597 {ECO:0000313|EMBL:ORA65181.1, ECO:0000313|Proteomes:UP000192801};
RN [1] {ECO:0000313|EMBL:ORA65181.1, ECO:0000313|Proteomes:UP000192801}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45130 {ECO:0000313|EMBL:ORA65181.1,
RC ECO:0000313|Proteomes:UP000192801};
RA Tortoli E., Trovato A., Cirillo D.M.;
RT "The new phylogeny of genus Mycobacterium.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:BBZ64949.1, ECO:0000313|Proteomes:UP000466223}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 16366 {ECO:0000313|EMBL:BBZ64949.1,
RC ECO:0000313|Proteomes:UP000466223};
RX PubMed=31287781;
RA Matsumoto Y., Kinjo T., Motooka D., Nabeya D., Jung N., Uechi K., Horii T.,
RA Iida T., Fujita J., Nakamura S.;
RT "Comprehensive subspecies identification of 175 nontuberculous mycobacteria
RT species based on 7547 genomic profiles.";
RL Emerg. Microbes Infect. 8:1043-1053(2019).
RN [3] {ECO:0000313|EMBL:BBZ64949.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JCM 16366 {ECO:0000313|EMBL:BBZ64949.1};
RA Matsumoto Y., Motooka D., Nakamura S.;
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily. Type III
CC sulfatase family. {ECO:0000256|ARBA:ARBA00033751}.
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DR EMBL; AP022618; BBZ64949.1; -; Genomic_DNA.
DR EMBL; MVHS01000066; ORA65181.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X0CYD5; -.
DR STRING; 444597.BST26_19030; -.
DR KEGG; mij:MINS_03780; -.
DR OrthoDB; 5240502at2; -.
DR Proteomes; UP000192801; Unassembled WGS sequence.
DR Proteomes; UP000466223; Chromosome.
DR GO; GO:0018741; F:linear primary-alkylsulfatase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0018909; P:dodecyl sulfate metabolic process; IEA:InterPro.
DR CDD; cd07710; arylsulfatase_Sdsa1-like_MBL-fold; 1.
DR Gene3D; 1.25.40.880; Alkyl sulfatase, dimerisation domain; 1.
DR Gene3D; 3.60.15.30; Metallo-beta-lactamase domain; 1.
DR Gene3D; 3.30.1050.10; SCP2 sterol-binding domain; 1.
DR InterPro; IPR038536; Alkyl/aryl-sulf_dimr_sf.
DR InterPro; IPR029229; Alkyl_sulf_C.
DR InterPro; IPR029228; Alkyl_sulf_dimr.
DR InterPro; IPR044097; Bds1/SdsA1_MBL-fold.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR InterPro; IPR036527; SCP2_sterol-bd_dom_sf.
DR PANTHER; PTHR43223; ALKYL/ARYL-SULFATASE; 1.
DR PANTHER; PTHR43223:SF1; ALKYL_ARYL-SULFATASE BDS1; 1.
DR Pfam; PF14864; Alkyl_sulf_C; 1.
DR Pfam; PF14863; Alkyl_sulf_dimr; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
DR SUPFAM; SSF55718; SCP-like; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:BBZ64949.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000192801};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 101..323
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 625 AA; 68339 MW; 023C7B6104D66DCE CRC64;
MESRLPSRFI EDAHSHALAT LPLADTVDFA DADRGFIGRL SPCVITAADG RVVWNNDEYD
FLTGDAPASV HPSLWRQSQL CARQGLYEVV DGIYQVRGLD ISNATFVESD TGVIVIDPLV
STETAAAALA LYRAHRGDRP VVAVVYTHSH VDHFGGVLGV TTQADVDAGR VPILAPEGFL
EHAVAENVYA GTAMARRAAY MYGAALDRGR QGQVGCGLGQ VPSAGEVAII PPTVHITSTG
QTECVDGVQI EFQMAPGTEA PAEMHFYFPR YRALCMAENA THNLHNLVTL RGAVVRDPHA
WSGYLTEAID TFVDRSDVVF ASHHWPIWGR DRVREYLSLQ RDLYAYLHDQ TLRLLNQGYT
GIEIAENFEL PPALRNAWHC HGYYGSVSHN VKAIYQRYLG WFDGNPGRLW QHPPEAAAPR
YVEAMGGVDR VVELARTAFE SGDYRWAATL LDHAVFADET HSGARELYAD TLEQLAYGAE
NATWRNFFLS GATELRVANF GTPTRTASPT LLGQLSPEQL FDAMAINING PQAWDLDLAM
DVTFADTGRN YRLTLRNGVL VYRRGAADPA TAGVTITLAE KARLLTLLAG DRDSPGLQIS
GDPQQLAALV AVLDRPDPGF NIVTP
//
