ID A0A1X0DGZ8_9MYCO Unreviewed; 140 AA.
AC A0A1X0DGZ8;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Cell wall synthesis protein CwsA {ECO:0000256|HAMAP-Rule:MF_00927};
DE AltName: Full=Cell wall synthesis and cell shape protein A {ECO:0000256|HAMAP-Rule:MF_00927};
GN Name=cwsA {ECO:0000256|HAMAP-Rule:MF_00927,
GN ECO:0000313|EMBL:BBZ65103.1};
GN ORFNames=BST26_07760 {ECO:0000313|EMBL:ORA71664.1}, MINS_05320
GN {ECO:0000313|EMBL:BBZ65103.1};
OS Mycolicibacterium insubricum.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=444597 {ECO:0000313|EMBL:ORA71664.1, ECO:0000313|Proteomes:UP000192801};
RN [1] {ECO:0000313|EMBL:ORA71664.1, ECO:0000313|Proteomes:UP000192801}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45130 {ECO:0000313|EMBL:ORA71664.1,
RC ECO:0000313|Proteomes:UP000192801};
RA Tortoli E., Trovato A., Cirillo D.M.;
RT "The new phylogeny of genus Mycobacterium.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:BBZ65103.1, ECO:0000313|Proteomes:UP000466223}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 16366 {ECO:0000313|EMBL:BBZ65103.1,
RC ECO:0000313|Proteomes:UP000466223};
RX PubMed=31287781;
RA Matsumoto Y., Kinjo T., Motooka D., Nabeya D., Jung N., Uechi K., Horii T.,
RA Iida T., Fujita J., Nakamura S.;
RT "Comprehensive subspecies identification of 175 nontuberculous mycobacteria
RT species based on 7547 genomic profiles.";
RL Emerg. Microbes Infect. 8:1043-1053(2019).
RN [3] {ECO:0000313|EMBL:BBZ65103.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JCM 16366 {ECO:0000313|EMBL:BBZ65103.1};
RA Matsumoto Y., Motooka D., Nakamura S.;
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for regulated cell division, cell wall synthesis and
CC the maintenance of cell shape. {ECO:0000256|HAMAP-Rule:MF_00927}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_00927};
CC Single-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_00927}.
CC Note=Localizes to poles and midcell sites. {ECO:0000256|HAMAP-
CC Rule:MF_00927}.
CC -!- SIMILARITY: Belongs to the CwsA family. {ECO:0000256|HAMAP-
CC Rule:MF_00927}.
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DR EMBL; AP022618; BBZ65103.1; -; Genomic_DNA.
DR EMBL; MVHS01000012; ORA71664.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X0DGZ8; -.
DR STRING; 444597.BST26_07760; -.
DR KEGG; mij:MINS_05320; -.
DR OrthoDB; 4762208at2; -.
DR Proteomes; UP000192801; Unassembled WGS sequence.
DR Proteomes; UP000466223; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR GO; GO:0042546; P:cell wall biogenesis; IEA:UniProtKB-UniRule.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00927; CwsA; 1.
DR InterPro; IPR024245; CwsA.
DR Pfam; PF10814; CwsA; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|HAMAP-Rule:MF_00927};
KW Cell division {ECO:0000256|HAMAP-Rule:MF_00927};
KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_00927};
KW Cell shape {ECO:0000256|HAMAP-Rule:MF_00927};
KW Membrane {ECO:0000256|HAMAP-Rule:MF_00927};
KW Reference proteome {ECO:0000313|Proteomes:UP000192801};
KW Transmembrane {ECO:0000256|HAMAP-Rule:MF_00927};
KW Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_00927}.
FT TRANSMEM 98..119
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00927"
SQ SEQUENCE 140 AA; 14478 MW; 53803DB5FD38F0BE CRC64;
MSSTADESLT PGRRLARGLA YTAVGPLDIG RGVLGLGVAS TRSAAANARL QVERARLRRQ
LAAAQEALSD DIAATQEAVA ELPAAIVRIG KSHRARRIGL ITGIAVVTLA GGAVAFSIIR
RSMQPDPSAL PPSVEVDPHP
//
