ID A0A1X0JHG7_9MYCO Unreviewed; 500 AA.
AC A0A1X0JHG7;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Aldehyde dehydrogenase {ECO:0000313|EMBL:ORB62382.1};
GN ORFNames=BST47_23905 {ECO:0000313|EMBL:ORB62382.1};
OS Mycolicibacterium tusciae.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=75922 {ECO:0000313|EMBL:ORB62382.1, ECO:0000313|Proteomes:UP000192411};
RN [1] {ECO:0000313|EMBL:ORB62382.1, ECO:0000313|Proteomes:UP000192411}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44153 {ECO:0000313|Proteomes:UP000192411};
RA Tortoli E., Trovato A., Cirillo D.M.;
RT "The new phylogeny of genus Mycobacterium.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH;
CC Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945; EC=1.2.1.3;
CC Evidence={ECO:0000256|ARBA:ARBA00024149};
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|RuleBase:RU003345}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORB62382.1}.
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DR EMBL; MVIM01000016; ORB62382.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X0JHG7; -.
DR STRING; 75922.BST47_23905; -.
DR eggNOG; COG1012; Bacteria.
DR OrthoDB; 6882680at2; -.
DR Proteomes; UP000192411; Unassembled WGS sequence.
DR GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IEA:UniProt.
DR GO; GO:0070887; P:cellular response to chemical stimulus; IEA:UniProt.
DR CDD; cd07139; ALDH_AldA-Rv0768; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR PANTHER; PTHR42804; ALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR42804:SF1; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003345}.
FT DOMAIN 29..490
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 266
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 500 AA; 53232 MW; B83D782A3EAA42FB CRC64;
MTQTVAHKTP AGEPAYRTQW DKLFIGGKWV EPASSEVIEV RSPATGEVVG KVPLATEADV
NAACAAARKA FDEGPWPHMK PQERAAILAA AIKGMEERAD ELKYLLAAET GQPQTIVDMM
QYGAAMSAFQ YYAGAADKFP WRDIRDGVYG QTLVVREPIG VVGAVTAWNV PFFLAANKLG
PAFLAGCTVV LKPAAETPLS VFAMAEIFAE AGLPEGVLSI VPGGPETGRA LTSNPELDKF
TFTGSSAVGK EIAKIAAEKL KPCTLELGGK SAAIILEDAD LDATLPMLGF SGVMNSGQAC
VAQTRILAPR SRYDEVVEKL SNFISAMPVG LPDDPNAAIG PLISEKQRER VEGYIKKGVE
EGARIVTGGG RPEGLDSGWF VQPTVFADVD NSMTIAQEEI FGPVLAVIPY ETEEDAIRIA
NDSVYGLAGS VWTTDNKKAI EIAKKIRTGT YAVNMYAFDP CAPFGGYKNS GVGRENGPEG
IEAYVEPKSV LLPFGYTPED
//
