ID A0A1X0NE47_9TRYP Unreviewed; 1284 AA.
AC A0A1X0NE47;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Cullin family profile domain-containing protein {ECO:0000259|PROSITE:PS50069};
GN ORFNames=TM35_001131070 {ECO:0000313|EMBL:ORC81581.1};
OS Trypanosoma theileri.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=67003 {ECO:0000313|EMBL:ORC81581.1, ECO:0000313|Proteomes:UP000192257};
RN [1] {ECO:0000313|EMBL:ORC81581.1, ECO:0000313|Proteomes:UP000192257}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Edinburgh {ECO:0000313|EMBL:ORC81581.1};
RA Kelly S., Ivens A., Mott A., O'Neill E., Emms D., Macleod O., Voorheis P.,
RA Matthews J., Matthews K., Carrington M.;
RT "An alternative strategy for trypanosome survival in the mammalian
RT bloodstream revealed through genome and transcriptome analysis of the
RT ubiquitous bovine parasite Trypanosoma (Megatrypanum) theileri.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the cullin family. {ECO:0000256|PROSITE-
CC ProRule:PRU00330}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORC81581.1}.
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DR EMBL; NBCO01000113; ORC81581.1; -; Genomic_DNA.
DR STRING; 67003.A0A1X0NE47; -.
DR VEuPathDB; TriTrypDB:TM35_001131070; -.
DR OrthoDB; 126575at2759; -.
DR Proteomes; UP000192257; Unassembled WGS sequence.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR20916:SF18; BED-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR20916; CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN; 1.
DR Pfam; PF10557; Cullin_Nedd8; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000192257}.
FT DOMAIN 729..899
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
FT REGION 69..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 211..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 556..579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 592..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 913..959
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 972..992
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1132..1156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..96
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..579
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 592..611
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1137..1156
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1284 AA; 145771 MW; 9953134D88AC70EA CRC64;
MEKDARVLIH WVRKWNVIND ALIYFANSSH ALHSFSVSNH NGICESNNEN SNEKLNSFSL
LESREDTNNN NLVSTQEDER NQGKKETSEK HEEKTSFTEA ADIGNISMLY AEVYGMVSIY
GKVGFWSNAV VLQHLLASSI RAWLEQLCIC SNNRLCIYPL QDTGELTPPQ LSWSTEMLES
LWEEALQANS KSWLQSVGKF AVAEIKNSSI SKSQMDNEPG DDHNNDSYKD NNNNNNNNNN
NNNNNNNNNS DSNYNSSNMR VHTKDEEDVM ALHTLVSFSL HYIRMRWLLK IVFLRVDVEM
NEIAWRILRS SVFLTLQYNK IMIEKILCHA AEQCLVKKCF DNNNNNNNNN NNNNNNNNNK
LRLSASTSEE DMEVSSFPYL LQRIWKGDTS LIFRVFTMLD DCRASSITNA VTERVVELCK
QQGFELAQVK LGPLLVHTGK CNPNNINNNN NNNNSEEMKK NTPTLEDVTA SLHQCMNAFL
QLRSAVLLFF GGTKHFLDKI SQLGRERAAQ ATRAFSIGFC QGDVLMKFVD IWAMPMWLHT
CTEECKRPLR DTGSFPYDSD GEHLNNNNNN NNNNNSDSSV IFHSMSEALS QLGETEETSL
NGTQRSYHHH YNNNNNNHHH HHNNDNNSTS SVPPHPGLAT LIFFISPELR LLEEFELHFA
VAVQQHLEDL LAKEQGVSET PRSLPREVYQ CCVFLLKMTN QMLQPIAAGG IYATLRAVRK
GIQTFFLRRE PSVILTLASA LYTQVVRDTA VDAGHLEIVD TILELVSLLH SKDLFIDCYA
GLLAPRLMKM RQVTELEVDT EVISRLSVRL GNSLASDLFA LLRDVRGSMI DVCCVNATNT
TVMEDSSPFM DDVRVLCSAR WEKYTPVMIR LTEMQLHFQT EGWFDESMLK TVEVFEKCYD
AYMHKSSSTL EDGRNNLFNN NNNNNNNNNN NNNNNNNNMN NNDDSSRNPP HHYNNLQYSN
TNHNHHIITN TNISHYNNSN NNDNNNDNNS HYYYYHDNSN NNNNNMNRES RLPASLVSPM
GVASTTTHRG VQRRLLSWSL GAGTLTVVCH AAQIEKDEPE STVQITMPPV GLLLLQALER
QDRLCSTDTD TSRALTFEAL YSLLPVKVPK PLFGVLLSGL VRHGIVRRHF HSEEETDTNN
NNNNNNNNNN NNNKRVGVNG KGFYTYTLPS NFTACKKRKI VIDAADAIHH WVPHAQDPRG
EGKSSVNALS GMVDVERMKK LEACIVRIMK SKRRLSHVSL FSCAAEQLGM QFAVTGPMLK
SCLAELIERE FLAREGTDNY IYIV
//
