ID A0A1X0NJ91_9TRYP Unreviewed; 907 AA.
AC A0A1X0NJ91;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
DE Flags: Fragment;
GN ORFNames=TM35_000401010 {ECO:0000313|EMBL:ORC84834.1};
OS Trypanosoma theileri.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=67003 {ECO:0000313|EMBL:ORC84834.1, ECO:0000313|Proteomes:UP000192257};
RN [1] {ECO:0000313|EMBL:ORC84834.1, ECO:0000313|Proteomes:UP000192257}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Edinburgh {ECO:0000313|EMBL:ORC84834.1};
RA Kelly S., Ivens A., Mott A., O'Neill E., Emms D., Macleod O., Voorheis P.,
RA Matthews J., Matthews K., Carrington M.;
RT "An alternative strategy for trypanosome survival in the mammalian
RT bloodstream revealed through genome and transcriptome analysis of the
RT ubiquitous bovine parasite Trypanosoma (Megatrypanum) theileri.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORC84834.1}.
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DR EMBL; NBCO01000040; ORC84834.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X0NJ91; -.
DR STRING; 67003.A0A1X0NJ91; -.
DR VEuPathDB; TriTrypDB:TM35_000401010; -.
DR OrthoDB; 122856at2759; -.
DR Proteomes; UP000192257; Unassembled WGS sequence.
DR CDD; cd00821; PH; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR39666:SF1; C2 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR39666; RANBP2-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000192257}.
FT DOMAIN 615..725
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 166..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 305..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 766..800
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 854..881
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 312..336
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ORC84834.1"
SQ SEQUENCE 907 AA; 102989 MW; 05595DE2E0C9FC0D CRC64;
ISTIDAILKA YNGREEEMFA ALVKKYGPEP PRDDCPPAIL NRETQSGNVR DRVVKDSERI
SVREVIQTIL SVAGASYTDV LLALPKESRR ALFSSKESTL HVDNSRKNMS DLRSTSNEPE
DVRSRLERFM RKYNPEKIST IDAILKAYNG REEEMFAALV KKYGPEPPRD DCPPADTPAP
TAVTPVGAHE PEDVRSRLER FMRKYNPGKI STIDAILKAY NGREEEMFAA LVKKYGPEPL
RDNLPLTTRK DETVSVTVDA EVLRTRLMRF FAKYAPEKLA GVDVLIESCE RHSVNELMNS
LVSTYGPEPV EESTGVKDDK KEQKKEVLQR EEETRGRIDD DERQKLLASL EASGKDAKMV
CYSLLTEMEL LSFVRTNFGD YEGRIRRLLV RYDPARLEAV PELLRAHCGR EDELIAQLTS
ELGPEPEKTA PTSLLRLMRR RADWRRIDED TWTDDEESNN DEVLLLRPPK GLTDGRSLIE
SYQANDPGEF SGDESAAYPH DEEHWYRLFF GGGPVDDGDA VGDDTAAGDA GSFGTQHADG
AVLQISPTVD SPSPSPPPSC ALRHRRVRGL QVTLGNKFGQ AIGALCAPCS VKVARSFEAL
WQPVGPQYQQ LLSETVVKDG YLEKLSSDGR RMGVKWQKRY FRVDDKGMHY YETNAPGEKP
KGYKVFTKDS IVIEHIDATV HPKCTDSRYH YFGITVNNSN DMFYLRTPSE DEKRLWVSFM
QLAFARVRLT TIGCDQNPSR WRGRMEGLKE AEIGLIDLVH ASSVVMQKLR KQHDELKERI
NAERAHRKLM ETQLSEMQEQ QAHLAQCVME AKARAHAVEE DVDVKCLELA ESAASVKQQR
LEMGNELEET RRSIDGITQT VINMQKEILE LESECETREA RVRQAYSKWR RCEGREYPEN
NSIWRSN
//
