ID   A0A1X0NJW9_9TRYP        Unreviewed;       588 AA.
AC   A0A1X0NJW9;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=ATP synthase subunit alpha, mitochondrial {ECO:0000256|ARBA:ARBA00016087};
GN   ORFNames=TM35_000381100 {ECO:0000313|EMBL:ORC85035.1};
OS   Trypanosoma theileri.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=67003 {ECO:0000313|EMBL:ORC85035.1, ECO:0000313|Proteomes:UP000192257};
RN   [1] {ECO:0000313|EMBL:ORC85035.1, ECO:0000313|Proteomes:UP000192257}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Edinburgh {ECO:0000313|EMBL:ORC85035.1};
RA   Kelly S., Ivens A., Mott A., O'Neill E., Emms D., Macleod O., Voorheis P.,
RA   Matthews J., Matthews K., Carrington M.;
RT   "An alternative strategy for trypanosome survival in the mammalian
RT   bloodstream revealed through genome and transcriptome analysis of the
RT   ubiquitous bovine parasite Trypanosoma (Megatrypanum) theileri.";
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the ATPase alpha/beta chains family.
CC       {ECO:0000256|ARBA:ARBA00008936}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ORC85035.1}.
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DR   EMBL; NBCO01000038; ORC85035.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1X0NJW9; -.
DR   STRING; 67003.A0A1X0NJW9; -.
DR   VEuPathDB; TriTrypDB:TM35_000381100; -.
DR   OrthoDB; 1102723at2759; -.
DR   Proteomes; UP000192257; Unassembled WGS sequence.
DR   GO; GO:0045261; C:proton-transporting ATP synthase complex, catalytic core F(1); IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046933; F:proton-transporting ATP synthase activity, rotational mechanism; IEA:InterPro.
DR   CDD; cd01132; F1-ATPase_alpha_CD; 1.
DR   Gene3D; 3.40.50.12240; -; 1.
DR   InterPro; IPR000793; ATP_synth_asu_C.
DR   InterPro; IPR033732; ATP_synth_F1_a_nt-bd_dom.
DR   InterPro; IPR005294; ATP_synth_F1_asu.
DR   InterPro; IPR020003; ATPase_a/bsu_AS.
DR   InterPro; IPR000194; ATPase_F1/V1/A1_a/bsu_nucl-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   NCBIfam; TIGR00962; atpA; 1.
DR   PANTHER; PTHR48082; ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR48082:SF2; ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR   Pfam; PF00006; ATP-synt_ab; 1.
DR   Pfam; PF00306; ATP-synt_ab_C; 1.
DR   SUPFAM; SSF47917; C-terminal domain of alpha and beta subunits of F1 ATP synthase; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00152; ATPASE_ALPHA_BETA; 1.
PE   3: Inferred from homology;
KW   ATP synthesis {ECO:0000256|ARBA:ARBA00023310};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   CF(1) {ECO:0000256|ARBA:ARBA00023196};
KW   Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000192257};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          190..413
FT                   /note="ATPase F1/V1/A1 complex alpha/beta subunit
FT                   nucleotide-binding"
FT                   /evidence="ECO:0000259|Pfam:PF00006"
FT   DOMAIN          420..505
FT                   /note="ATP synthase alpha subunit C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00306"
SQ   SEQUENCE   588 AA;  63751 MW;  372D2EF74A2AE94E CRC64;
     MRRFVCKLAT GLPVRFASTT ATAGGAKAAS ATATTAAGAG SAAAGQKSFF KATEMIGYVH
     SIDGTIATLI PAPGNPGVAY NTIIQIQVSP TTFAAGLVFN LEKDGRIGII LMDNITEVQS
     GQKVMATGQL LHIPVGSGVL GKVVNPLGHE VPVGLFTRSR CLLNQTVGKV DAGAPNIVSR
     SPVNYNLLTG FKAVDTMIPI GRGQRELIVG DRQTGKTSIA VSTIINQVRI NQQILSKNAV
     ISIYVSIGQR CSNVARIHRL LQSYGALRYT TVMAATAAEP AGLQYLAPYA GVTMGEYFMN
     RGRHCLCVYD DLSKQAVAYR QISLLLRRPP GREAYPGDVF YLHSRLLERA AMLSPGKGGG
     SVTALPIVET LSNDVTAYIV TNVISITDGQ IYLDTKLFTG GQRPAVNIGL SVSRVGSSAQ
     NVAMKGVAGK LKGILAEYRK LAADSVGGQQ VQTIPMIRGA RFVALFNQKQ PSYFMSAIVS
     LYACLNGYLD DVKVQYVKFY EYLLVHKDLS IMYGSAKNKF FYMYVQELNY LIRFFTLNSP
     ILHGELEEML KQHTQLFLQH YQSRMNAIKS EKEVKALKNL LYSCKRAV
//