ID A0A1X0NMN7_9TRYP Unreviewed; 1000 AA.
AC A0A1X0NMN7;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Protein transport protein Sec24C {ECO:0008006|Google:ProtNLM};
GN ORFNames=TM35_000332100 {ECO:0000313|EMBL:ORC85753.1};
OS Trypanosoma theileri.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=67003 {ECO:0000313|EMBL:ORC85753.1, ECO:0000313|Proteomes:UP000192257};
RN [1] {ECO:0000313|EMBL:ORC85753.1, ECO:0000313|Proteomes:UP000192257}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Edinburgh {ECO:0000313|EMBL:ORC85753.1};
RA Kelly S., Ivens A., Mott A., O'Neill E., Emms D., Macleod O., Voorheis P.,
RA Matthews J., Matthews K., Carrington M.;
RT "An alternative strategy for trypanosome survival in the mammalian
RT bloodstream revealed through genome and transcriptome analysis of the
RT ubiquitous bovine parasite Trypanosoma (Megatrypanum) theileri.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
CC {ECO:0000256|ARBA:ARBA00008334}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORC85753.1}.
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DR EMBL; NBCO01000033; ORC85753.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X0NMN7; -.
DR STRING; 67003.A0A1X0NMN7; -.
DR VEuPathDB; TriTrypDB:TM35_000332100; -.
DR OrthoDB; 977017at2759; -.
DR Proteomes; UP000192257; Unassembled WGS sequence.
DR GO; GO:0030127; C:COPII vesicle coat; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR Gene3D; 2.60.40.1670; beta-sandwich domain of Sec23/24; 1.
DR Gene3D; 1.20.120.730; Sec23/Sec24 helical domain; 1.
DR Gene3D; 3.40.20.10; Severin; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR006900; Sec23/24_helical_dom.
DR InterPro; IPR036175; Sec23/24_helical_dom_sf.
DR InterPro; IPR006896; Sec23/24_trunk_dom.
DR InterPro; IPR012990; Sec23_24_beta_S.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR006895; Znf_Sec23_Sec24.
DR InterPro; IPR036174; Znf_Sec23_Sec24_sf.
DR PANTHER; PTHR13803; SEC24-RELATED PROTEIN; 1.
DR PANTHER; PTHR13803:SF4; SECRETORY 24CD, ISOFORM C; 1.
DR Pfam; PF08033; Sec23_BS; 1.
DR Pfam; PF04815; Sec23_helical; 1.
DR Pfam; PF04811; Sec23_trunk; 1.
DR Pfam; PF04810; zf-Sec23_Sec24; 1.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 1.
DR SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 1.
DR SUPFAM; SSF81811; Helical domain of Sec23/24; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR SUPFAM; SSF82919; Zn-finger domain of Sec23/24; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000192257};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 323..361
FT /note="Zinc finger Sec23/Sec24-type"
FT /evidence="ECO:0000259|Pfam:PF04810"
FT DOMAIN 408..641
FT /note="Sec23/Sec24 trunk"
FT /evidence="ECO:0000259|Pfam:PF04811"
FT DOMAIN 649..733
FT /note="Sec23/Sec24 beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF08033"
FT DOMAIN 743..843
FT /note="Sec23/Sec24 helical"
FT /evidence="ECO:0000259|Pfam:PF04815"
FT REGION 1..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 99..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..70
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..251
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1000 AA; 112194 MW; B2BA327AFAD18B79 CRC64;
MYYPYGGAQQ PQQPQPPGQS TPQYHPQQQQ SPPPTMFGQM PGPSPSWNEY GNQQYTPAIP
LSTTTTTTSN TNANTAGAGV YQDPYTSAAG VNGLHDYNST YYQTSNQPQQ QSYHNYQQPP
PQQQQQQQQP LPPQQQMQGM QTQSPQSAAV PSPMPHVGGP PLMASNLPQR GAPIPSTDPV
QQNRQPLTPT TDAFSNTYNN NNNNNSTSQR DRCVTPIGKY ARIPPKRQVD LKSAPNPRRD
ISQKPEEHEY RTSSGQMPMS VFDFVAIDDG NASAKFFRPT TCSIPSEERL VKDSKVSFGA
VLAPLCRPLH PSEEVPIVEG RPPARCHRCR GYISCHARFT DMGRYWVCPL CSMSNEVEEA
YFCNLDARNN RLDRAEKPEL ARGSVEYDVG PYDEYSLRDE KENPIPMRPL HYLFLIDVSQ
KAATTFLSDY VDALLKSLHE MAQQYPQCRV AFITYASTLH FYNVRHPRIP QLIVADVDNP
FVPLPFTSLC WLTLGTDLDL VDAFLMRVPE YADDLRETDS ALGAAVQVAM LVLAGQHGGH
VVVSAHKAPQ CGIGAIKLRE QHTLYGTDKE KELLRPIEGF WKTTATTCAK QQISFDLHMF
ADQYCELVTL SQPCHLSNGR VHLFPNYDRE TDATKVQAVL DQVLLEEAGY AGILRVRCST
GLRVQGYHGH FLSQDSHDMD LAHVQGSSTF FVEFAHEGKL EKNSHAFFQT ALLYTTRGGQ
RRVRVHSVRM PVVTTLLAVF DADLEATLVG YIHEAVGNAV NKGLQYARNA AQERVLKMLI
AYRRVCTSNS STSLLMPSRL RLLPLYVLSL LKADALVEGT TVRIDDRVQK LFHLMTIPMH
QCLMYLYPTL YAVHLLPSDA NSGTLDPTTG RCIMPGWRQL FYESITSDGV YVLCDEQARL
VYLWVGSQVS PQISKELFGT EIAAEVGRTV FFDGFGEKLR NVLWACLLRD DGMRRLIILH
EKDRAEDAFF RQLKEENEGG VMGYDQFLVR LHKDVNKALA
//
