ID A0A1X0NMZ1_9TRYP Unreviewed; 394 AA.
AC A0A1X0NMZ1;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE SubName: Full=Delta8 fatty acid desaturase-like protein {ECO:0000313|EMBL:ORC85499.1};
GN ORFNames=TM35_000341110 {ECO:0000313|EMBL:ORC85499.1};
OS Trypanosoma theileri.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=67003 {ECO:0000313|EMBL:ORC85499.1, ECO:0000313|Proteomes:UP000192257};
RN [1] {ECO:0000313|EMBL:ORC85499.1, ECO:0000313|Proteomes:UP000192257}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Edinburgh {ECO:0000313|EMBL:ORC85499.1};
RA Kelly S., Ivens A., Mott A., O'Neill E., Emms D., Macleod O., Voorheis P.,
RA Matthews J., Matthews K., Carrington M.;
RT "An alternative strategy for trypanosome survival in the mammalian
RT bloodstream revealed through genome and transcriptome analysis of the
RT ubiquitous bovine parasite Trypanosoma (Megatrypanum) theileri.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the fatty acid desaturase type 1 family.
CC {ECO:0000256|ARBA:ARBA00009295}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORC85499.1}.
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DR EMBL; NBCO01000034; ORC85499.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X0NMZ1; -.
DR STRING; 67003.A0A1X0NMZ1; -.
DR VEuPathDB; TriTrypDB:TM35_000341110; -.
DR OrthoDB; 294339at2759; -.
DR Proteomes; UP000192257; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd03506; Delta6-FADS-like; 1.
DR Gene3D; 3.10.120.10; Cytochrome b5-like heme/steroid binding domain; 1.
DR InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR InterPro; IPR005804; FA_desaturase_dom.
DR InterPro; IPR012171; Fatty_acid_desaturase.
DR PANTHER; PTHR19353:SF19; DELTA(5) FATTY ACID DESATURASE C-RELATED; 1.
DR PANTHER; PTHR19353; FATTY ACID DESATURASE 2; 1.
DR Pfam; PF00173; Cyt-b5; 1.
DR Pfam; PF00487; FA_desaturase; 1.
DR PIRSF; PIRSF015921; FA_sphinglp_des; 1.
DR SUPFAM; SSF55856; Cytochrome b5-like heme/steroid binding domain; 1.
DR PROSITE; PS50255; CYTOCHROME_B5_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000192257};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 114..139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 225..247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 259..288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..76
FT /note="Cytochrome b5 heme-binding"
FT /evidence="ECO:0000259|PROSITE:PS50255"
SQ SEQUENCE 394 AA; 46556 MW; 00467B5B65E316C1 CRC64;
MPFELIPPHA YQTKIPKCIL RIDDNWYDCT SWRHSHPGGA MICDQFHDKD ATDVFYSLHS
KEAIQKLKRM KALPLRETDK PRDEVSLRFE KLRKELEKDG WFERDWFIDF TRNIIPVIIL
CVVGSFLSYS YPLISIIMIG LGMQQGGWLA HDFGHGRGKL SHFLGVTLGG LINGFSLSWW
SQKHNTHHTF PNRKEHDADI HNEPVLYLWT PKDEDDNFFR RYQHFYYPFA YSLLYISWRM
QSIIFVLGSR NTVERLMIVL NYLWLACLPW KVVIGSILLG GFCVAIVVTA NHQTEEILEP
NDNYHYVVDQ YRTTRGVHCS SMFFEWFFGG MQYQLEHHLF PMMPRYRYPK ARTVVKKFSE
ENSLPFHVNG VMEIIRMNYD VIKKNSQPIE SIQK
//
