ID A0A1X0NP30_9TRYP Unreviewed; 1230 AA.
AC A0A1X0NP30;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Puromycin-sensitive aminopeptidase-like protein {ECO:0000313|EMBL:ORC85890.1};
GN ORFNames=TM35_000322050 {ECO:0000313|EMBL:ORC85890.1};
OS Trypanosoma theileri.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=67003 {ECO:0000313|EMBL:ORC85890.1, ECO:0000313|Proteomes:UP000192257};
RN [1] {ECO:0000313|EMBL:ORC85890.1, ECO:0000313|Proteomes:UP000192257}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Edinburgh {ECO:0000313|EMBL:ORC85890.1};
RA Kelly S., Ivens A., Mott A., O'Neill E., Emms D., Macleod O., Voorheis P.,
RA Matthews J., Matthews K., Carrington M.;
RT "An alternative strategy for trypanosome survival in the mammalian
RT bloodstream revealed through genome and transcriptome analysis of the
RT ubiquitous bovine parasite Trypanosoma (Megatrypanum) theileri.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORC85890.1}.
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DR EMBL; NBCO01000032; ORC85890.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X0NP30; -.
DR STRING; 67003.A0A1X0NP30; -.
DR VEuPathDB; TriTrypDB:TM35_000322050; -.
DR OrthoDB; 125664at2759; -.
DR Proteomes; UP000192257; Unassembled WGS sequence.
DR GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR Gene3D; 2.60.40.1730; tricorn interacting facor f3 domain; 1.
DR InterPro; IPR045357; Aminopeptidase_N-like_N.
DR InterPro; IPR042097; Aminopeptidase_N-like_N_sf.
DR InterPro; IPR014782; Peptidase_M1_dom.
DR InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR PANTHER; PTHR11533; PROTEASE M1 ZINC METALLOPROTEASE; 1.
DR PANTHER; PTHR11533:SF174; PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED; 1.
DR Pfam; PF01433; Peptidase_M1; 1.
DR Pfam; PF17900; Peptidase_M1_N; 1.
DR SUPFAM; SSF63737; Leukotriene A4 hydrolase N-terminal domain; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 4: Predicted;
KW Aminopeptidase {ECO:0000313|EMBL:ORC85890.1};
KW Hydrolase {ECO:0000313|EMBL:ORC85890.1};
KW Protease {ECO:0000313|EMBL:ORC85890.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000192257}.
FT DOMAIN 39..243
FT /note="Aminopeptidase N-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF17900"
FT DOMAIN 409..614
FT /note="Peptidase M1 membrane alanine aminopeptidase"
FT /evidence="ECO:0000259|Pfam:PF01433"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 95..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 796..816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..129
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1230 AA; 137267 MW; 8AE70F90B8093FDA CRC64;
MLEHQKDSKQ YQQEKQGGGE EEEGKNESKF FHLPSHFLPR RYDLFFSPRP VQGLFIGSTV
VTIEVASPLP QPTRHITLHA LNLSIDSEDV KIKTGIHNSS GDIEGSGDSV SSTVEEEEEE
EEEEEEDDEG VLHCVGIRSS EENETITIEF DSELPNVKGT TFTLHFVHFG GIIQPSSTAT
GLFYSYTQDN NFLSTHLEPT DARRLYPCFD EPSFRAVFQL TVEFDSRYSI IAGTLPVHEE
HLELDEVAYA ATFFDYASPE STPDRFWGFS NSNSLNSSTP GPSINSRMLK GEGGMGSIRM
GSEMNGMSYP HGSHSLYLFP RSQTCEPYST ATTTAAAAAG GGGGGECLDE EPRVCSLRRV
MFDVTPCLST YHIGFHTGKF HILEKSASRW PLLCRVVFPL DVHVSQGWYA LDLLTKAVDF
FDDYYDHPLP LSKLDLVSVP SAGMLGASLW GLIPLHQSFL LVGESTPVER RQRIARAVGH
GVSLQWLGGW AAAGRWEAAW LADGVARHVE FAFVNALFPG WMAWDEFLAQ LLDDALALDT
QAEKTHPVNY VSPNPRRIRD TFDSISCGKG AAIIRMLEGL LGRNHMQQAI QMLLQRCGGS
IFDEKIFLNC LCSVHHSPGQ DLDEVATAVM QYAERSGHPL LYIEQRNGVC RVTQYETPDL
REGVIHTYAQ LQPQRTEKID AMDLMAPRRL RSFKWNIDNL LKRTNYTIPV SIMEVKHGST
SFAHTYIIRN SQESITCTPD QLIFFNYRGT SVLRCDYDTA TWRRIFEIAP FLSSEDRMII
TITLFRFRNI HIGQDENSNN NNNNNNNNDD DINSINNSSE KTGDNIDRCL LLLEWLLFIS
KTTFMNSSQW KYITHNLEQV SYMVRDYHCW SVFSHFVCTL YAPLLHRGAV SFAATENAVS
FESQTNLSRE TVLHILQLLA ICRSPLIQDE AQQLVAWALA ALGVVTTSSR AGGFNVDNDT
DAAGVSIAMQ SLTERGDSNT WCTLASLLLT LLGHPTHTVP LPEVENMNMN SDLDMEIDAE
VLLRVSQLDK TQETRWINMI APAVFALDRS STLSLQLIIL QYFTTLNAPI AKAMLRNKRL
MIRLFEPNGL IGWGKRLSNI RSLLIVYGAT FCSDAVLLGL MKACVVGDAP MEGIVSPTSE
INTSSTTTPT AISQKQFTAD NRESVVGCSR SVVNAIAKME VNCLWMEYCC DHYYNFLSTK
LPSSGLNSMG LFPFSSATEG SIDESIGVSI
//