ID A0A1X0NS98_9TRYP Unreviewed; 808 AA.
AC A0A1X0NS98;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Putative cullin 2 {ECO:0000313|EMBL:ORC87059.1};
GN ORFNames=TM35_000242090 {ECO:0000313|EMBL:ORC87059.1};
OS Trypanosoma theileri.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=67003 {ECO:0000313|EMBL:ORC87059.1, ECO:0000313|Proteomes:UP000192257};
RN [1] {ECO:0000313|EMBL:ORC87059.1, ECO:0000313|Proteomes:UP000192257}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Edinburgh {ECO:0000313|EMBL:ORC87059.1};
RA Kelly S., Ivens A., Mott A., O'Neill E., Emms D., Macleod O., Voorheis P.,
RA Matthews J., Matthews K., Carrington M.;
RT "An alternative strategy for trypanosome survival in the mammalian
RT bloodstream revealed through genome and transcriptome analysis of the
RT ubiquitous bovine parasite Trypanosoma (Megatrypanum) theileri.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the cullin family.
CC {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC ECO:0000256|RuleBase:RU003829}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORC87059.1}.
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DR EMBL; NBCO01000024; ORC87059.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X0NS98; -.
DR STRING; 67003.A0A1X0NS98; -.
DR VEuPathDB; TriTrypDB:TM35_000242090; -.
DR OrthoDB; 167806at2759; -.
DR Proteomes; UP000192257; Unassembled WGS sequence.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 3.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11932:SF178; 1, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR11932; CULLIN; 1.
DR Pfam; PF00888; Cullin; 1.
DR Pfam; PF10557; Cullin_Nedd8; 1.
DR SMART; SM00182; CULLIN; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF74788; Cullin repeat-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000192257}.
FT DOMAIN 430..653
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
SQ SEQUENCE 808 AA; 91864 MW; 18FE7F013F7D602A CRC64;
MGYPSAGDEQ HFDVVSAYSG SLFAKTFDFN ALWSRVSSVC NNILAWDESP DFKGQKAIQE
VVRAYTIVYR LVSAPCNECP KLVRGSTNQE DVVGNGLEGT QALVVYYLLR DMIRSWLSKT
VLHRLKASIN TDPSGLLKTY LKEWKTFIVA VNNLRVVFSY LHGPWQKYGA PPEHPLLPTE
VLALIQWNEV IMVPVITDPM GKEVLNLIAQ DRKNPLDGTN CVLLRELSEA LGTLSDPRAN
FYVTTIEEPY IHLLQTFCQD NKPQKTKCDV LEYINWCLNL FREEAGRAEQ ILNKSSIPLI
KQRMADVLID KNIDYLVGPL SLWMVNNNGS GLLVMYELMS KSTTGLTKFT DTIIDTVFRK
GMDEVDKMCE ESVRKGESIY RAVLKGIISV NTYFEPARAP FKELKVLDKP MSSGLEKVLE
NTRHIKSRTA LGEELARLAH MELKSHGTSE DFNRAIREIV LLFELLPSKA SFLESYPKYL
TERLLSETYC ETFERLTIEK ISESKGCTND FLHKCEIMLS DVVENSKSLL DEFNLTRSDG
FTKDSWVFNP RVLTCYMWTA ISADTSIPIP SCLSIRIMEY QKFFSRVRPK RHLTFVSRFS
RGVVKMNLPR GSGIQSLELH VGQLQLLLTE YFNQVDEWNV EELFKIISLP QNDALFSAIN
AFVRHGIFEI FNGEEKVDLP LDKVLPNYII RLVPLPAAKK RKLLLYPYEW GGTLQNTMAN
SSEFSNDHVD ASYVADQVKT PAIQATLIRV FKSSGTLSFA QLLEKVKDES LPHFTPTVQQ
VKVSLEFLIN RGFISRSDTN GNDFSYVS
//
