ID   A0A1X0NSV7_9TRYP        Unreviewed;       716 AA.
AC   A0A1X0NSV7;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=VASt domain-containing protein {ECO:0000259|PROSITE:PS51778};
GN   ORFNames=TM35_000201960 {ECO:0000313|EMBL:ORC87787.1};
OS   Trypanosoma theileri.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=67003 {ECO:0000313|EMBL:ORC87787.1, ECO:0000313|Proteomes:UP000192257};
RN   [1] {ECO:0000313|EMBL:ORC87787.1, ECO:0000313|Proteomes:UP000192257}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Edinburgh {ECO:0000313|EMBL:ORC87787.1};
RA   Kelly S., Ivens A., Mott A., O'Neill E., Emms D., Macleod O., Voorheis P.,
RA   Matthews J., Matthews K., Carrington M.;
RT   "An alternative strategy for trypanosome survival in the mammalian
RT   bloodstream revealed through genome and transcriptome analysis of the
RT   ubiquitous bovine parasite Trypanosoma (Megatrypanum) theileri.";
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ORC87787.1}.
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DR   EMBL; NBCO01000020; ORC87787.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1X0NSV7; -.
DR   STRING; 67003.A0A1X0NSV7; -.
DR   VEuPathDB; TriTrypDB:TM35_000201960; -.
DR   OrthoDB; 127183at2759; -.
DR   Proteomes; UP000192257; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043226; C:organelle; IEA:UniProt.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR   InterPro; IPR004182; GRAM.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR031968; VASt.
DR   PANTHER; PTHR23319:SF4; AT22714P-RELATED; 1.
DR   PANTHER; PTHR23319; UNCHARACTERIZED; 1.
DR   Pfam; PF02893; GRAM; 2.
DR   Pfam; PF16016; VASt; 1.
DR   SMART; SM00568; GRAM; 2.
DR   PROSITE; PS51778; VAST; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000192257};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        634..658
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          419..597
FT                   /note="VASt"
FT                   /evidence="ECO:0000259|PROSITE:PS51778"
FT   REGION          153..190
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          203..237
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        153..174
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        203..219
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   716 AA;  80445 MW;  9D1F798CEB664E99 CRC64;
     MSVDGSVSPS RTSTQNEKSA VALYTPEEQV FHRLFPQVPL SEKLVESRQC ALTTKKKKFA
     RMGTLYASSL RVCFGSPFLK DPIMVRWEDV TYVDKGSNFI FDSIVIKTKQ EEELMFSGFL
     SGGTGQIFKL LRTLWTVRVR YVLSGAPVPV QTTVPSPVIP AQGSSKSSDS LSSPSEEDTS
     RDDEENSLID TVSSTKPIIA EIVSSTPPYN STKTDSDTTL YSDKGNENEE KSHSLSTSVG
     KAFIGQDTAP EKYEVLQQFP RIPKSEPLID YFQCSYVSGV HRIGRIYITT NYILFSSVMM
     SERLQIAFKE VKNIEKEQTM VILDGIAVRL NNGSTHSFTG FVSRDAAFNI LTHFFNAMKT
     LNPPPQSLPY INETIDGEVA FTTKTSEADM SKIPVVDSLN EFSKVLTDYG TALSDFSCFT
     KELMDPVVLP EGKTVFDVFK VCFDDSSSIM EEYHRDRKDT DQKWEPWRPA LTGSPIFSGQ
     RQFKCTTIIR ALVAKACPFT EYQRYAFMNV EGREPTLVVQ LSGQAEGVMF ADAFRAEALL
     IFTQNDAKLT MRAFGHIQFL RDVWVKGKIL RASIDNEMPE CYRKLSTMLT ERLKHISSVR
     GLTHTTEETV YLTPPTERDL VSNLNLSFFQ IEEFLYGGNV VLSVLGLIAS LTGLYSVFFL
     NLDENSWKLH SSGKEGLLFL GLVKTFFELL RPTILSVLAF GILKFYRLLA KEIFSI
//