ID   A0A1X0NTW1_9TRYP        Unreviewed;      1020 AA.
AC   A0A1X0NTW1;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Putative RAB GDP dissociation inhibitor alpha {ECO:0000313|EMBL:ORC88144.1};
GN   ORFNames=TM35_000182010 {ECO:0000313|EMBL:ORC88144.1};
OS   Trypanosoma theileri.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=67003 {ECO:0000313|EMBL:ORC88144.1, ECO:0000313|Proteomes:UP000192257};
RN   [1] {ECO:0000313|EMBL:ORC88144.1, ECO:0000313|Proteomes:UP000192257}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Edinburgh {ECO:0000313|EMBL:ORC88144.1};
RA   Kelly S., Ivens A., Mott A., O'Neill E., Emms D., Macleod O., Voorheis P.,
RA   Matthews J., Matthews K., Carrington M.;
RT   "An alternative strategy for trypanosome survival in the mammalian
RT   bloodstream revealed through genome and transcriptome analysis of the
RT   ubiquitous bovine parasite Trypanosoma (Megatrypanum) theileri.";
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the Rab GDI family.
CC       {ECO:0000256|ARBA:ARBA00005593}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ORC88144.1}.
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DR   EMBL; NBCO01000018; ORC88144.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1X0NTW1; -.
DR   STRING; 67003.A0A1X0NTW1; -.
DR   VEuPathDB; TriTrypDB:TM35_000182010; -.
DR   OrthoDB; 5470823at2759; -.
DR   Proteomes; UP000192257; Unassembled WGS sequence.
DR   GO; GO:0005092; F:GDP-dissociation inhibitor activity; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   Gene3D; 1.10.405.10; Guanine Nucleotide Dissociation Inhibitor, domain 1; 1.
DR   Gene3D; 3.30.519.10; Guanine Nucleotide Dissociation Inhibitor, domain 2; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR018203; GDP_dissociation_inhibitor.
DR   InterPro; IPR019410; Methyltransf_16.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR11787; RAB GDP-DISSOCIATION INHIBITOR; 1.
DR   PANTHER; PTHR11787:SF4; RAB PROTEINS GERANYLGERANYLTRANSFERASE COMPONENT A; 1.
DR   Pfam; PF00996; GDI; 1.
DR   Pfam; PF10294; Methyltransf_16; 2.
DR   PRINTS; PR00891; RABGDIREP.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000192257}.
FT   REGION          657..684
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          883..904
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          918..963
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        658..684
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        918..951
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1020 AA;  115388 MW;  56FDADBD45914A47 CRC64;
     MSSDDEQGFG DLFASAEETV PVYPIEELHV DRMQLQCEGS TNPGFTTHLE AFDHPTPQDR
     TDLPLTPLKV YFRNKRHSLW GHRLWNAAKY MVKRMDTQMI DVRGKTVLEL GAGLGVPSLA
     AFRNGARCVV VTDYPDEDLL EILEMNVKAN CTPDLLDNDA SSFLLKEAER RKAMWSTVND
     KNKDDNNNTK ESLLDEVERQ RATQTHCVVE PLLWGKEEHI RKVLSYTGGA GFDIVILSDI
     LFNHFCNDDL ADTLARVLQR SRNSAAYCVF SHHRAHKQVE DLQFFDKCVA RGLRYEQLDE
     ESYPMMFPDD RGPEEIRQPV RVYKIIHYFD AAGAAFPPGE DIFDVVLHGT GVVESMLSAA
     LARCGVRVLH CDGQEDYGGV FKTLNIKQMR EYLAVRGVEE EEEEKEEKRD IHIMVDRMDE
     IESRIRGKYL LDLLPTHYLS NGETVQQLIK SDMARHLEFC CVSGFTFLMP LSSKPDNDNN
     GFGLQSIPLT RSQVFVDDRM SLIQKRRLMK FVKDVEATLA EQTHARTAET GDDPYSQAAV
     EHARAVVEAA VARFAEEAMK HPEETLSMML ERKYGIAEAA ADIVTLMQQL DITPPDVVRS
     VSLVRHVLTS CGAFGGETPF LQAMYGAAEI PQNMCRIAAV WNAVFVLRRG LHRVVPSGYK
     QHNNNNNNNN NNNNNNNNNN NKSDMIEQVN YPCVELSNLQ RIKTKVVVLP QIIANRFTSL
     SSDTMNNKDK NINNGVCFSR VIMIARKPLV TWAELRASGC IKTTTTTEND NSEDINEKSP
     PIVFALCRAK PGAVVHVQQL SAASEQAPND NTSVIIHFTV NEEEMTAVEL REFVKQRFVK
     QHAESSTVKP HSSGVGIDES DVIFFASFVL REREEAERSR VAANNNNNNN NNNNNNNNNN
     NANVSETCRA HPYAVEEYRK RQEQHQREQE HLLEEDKEKD GSSKDNINND NKDNEDEEDE
     DSCVVVPVPT LFQNLIDDGA YVEAARKAFY TIMSKLQKPQ EEGKSYEFLE RLPPVNAENA
//