ID   A0A1X0NU76_9TRYP        Unreviewed;       573 AA.
AC   A0A1X0NU76;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   RecName: Full=Membrane transporter protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=TM35_000201480 {ECO:0000313|EMBL:ORC87739.1};
OS   Trypanosoma theileri.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=67003 {ECO:0000313|EMBL:ORC87739.1, ECO:0000313|Proteomes:UP000192257};
RN   [1] {ECO:0000313|EMBL:ORC87739.1, ECO:0000313|Proteomes:UP000192257}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Edinburgh {ECO:0000313|EMBL:ORC87739.1};
RA   Kelly S., Ivens A., Mott A., O'Neill E., Emms D., Macleod O., Voorheis P.,
RA   Matthews J., Matthews K., Carrington M.;
RT   "An alternative strategy for trypanosome survival in the mammalian
RT   bloodstream revealed through genome and transcriptome analysis of the
RT   ubiquitous bovine parasite Trypanosoma (Megatrypanum) theileri.";
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000256|ARBA:ARBA00010199}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ORC87739.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; NBCO01000020; ORC87739.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1X0NU76; -.
DR   STRING; 67003.A0A1X0NU76; -.
DR   VEuPathDB; TriTrypDB:TM35_000201480; -.
DR   OrthoDB; 126915at2759; -.
DR   Proteomes; UP000192257; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR   CDD; cd13132; MATE_eukaryotic; 1.
DR   InterPro; IPR045069; MATE_euk.
DR   InterPro; IPR002528; MATE_fam.
DR   NCBIfam; TIGR00797; matE; 1.
DR   PANTHER; PTHR11206:SF153; ETHIONINE RESISTANCE-CONFERRING PROTEIN 1; 1.
DR   PANTHER; PTHR11206; MULTIDRUG RESISTANCE PROTEIN; 1.
DR   Pfam; PF01554; MatE; 2.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000192257};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        69..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        114..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        144..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        180..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        209..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        289..315
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        327..350
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        403..423
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        429..451
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   573 AA;  62850 MW;  AAFB9CF83A376F32 CRC64;
     MPSLNSSFVG EAAQHARIHE SVSITSIFKR IILISIPLNL AQLAQFSINV SIISVVGKLG
     VNQLGGASLG YGLINATAFA FASGFCGALE TVLSHTYGRD PKSKMYGIYA QRMTLMLLLV
     GLFLSPIILF IDRILLWLGQ DPDVVQYTGE FCRAAVWGVF PVMALELLRR YFACQHLNNI
     LSINLMVGAV LFPFLLIFLV NIFGFIGAPF GWCILMICMS GGLWLYLVIT RKYKDTWGGW
     DDAAYKHWGP LLALAIPSMG MMLSEWVSLE INNICAGFGT PEELAAFGIT FQLSGVCWSN
     AAGTFIAASV LVGNAIGEGK PKLARTIAYC SLITTISIAI FNLIIVSLVK DIFPYMFTDS
     EKVVKIVHSL LKYFFVYHTF DAFQSCMMGV LRGCGMQKQG AIVILFVYSI VGVPLGVFLF
     LKMSFGIEAL WLGPAFGVTV IGFPCYVFML LRVIKWDSLK PHTDHHELDY VMEEEKEDVA
     SVVICSSESM SNLTLVGNEE EEDEALKGKR ESTVNRKNTN DTIITVGLTS SSITANNTSS
     SSSAVVNGID RICEVLPTRS SGVSIEPTRE KKE
//