ID A0A1X0NWZ1_9TRYP Unreviewed; 3085 AA.
AC A0A1X0NWZ1;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Putative neurobeachin/beige protein {ECO:0000313|EMBL:ORC88630.1};
GN ORFNames=TM35_000162680 {ECO:0000313|EMBL:ORC88630.1};
OS Trypanosoma theileri.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=67003 {ECO:0000313|EMBL:ORC88630.1, ECO:0000313|Proteomes:UP000192257};
RN [1] {ECO:0000313|EMBL:ORC88630.1, ECO:0000313|Proteomes:UP000192257}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Edinburgh {ECO:0000313|EMBL:ORC88630.1};
RA Kelly S., Ivens A., Mott A., O'Neill E., Emms D., Macleod O., Voorheis P.,
RA Matthews J., Matthews K., Carrington M.;
RT "An alternative strategy for trypanosome survival in the mammalian
RT bloodstream revealed through genome and transcriptome analysis of the
RT ubiquitous bovine parasite Trypanosoma (Megatrypanum) theileri.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORC88630.1}.
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DR EMBL; NBCO01000016; ORC88630.1; -; Genomic_DNA.
DR VEuPathDB; TriTrypDB:TM35_000162680; -.
DR OrthoDB; 47483at2759; -.
DR Proteomes; UP000192257; Unassembled WGS sequence.
DR GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR CDD; cd06071; Beach; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF163; LYSOSOMAL-TRAFFICKING REGULATOR; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 2.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000192257};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274};
KW Ribosomal protein {ECO:0000256|ARBA:ARBA00022980};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 2248..2388
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2398..2694
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 2896..2937
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1252..1274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3085 AA; 351049 MW; 1080FE8B342E67FE CRC64;
MENDSKDNAL CMNETQLVSK FWASVTEFCF ASHDVNLEYQ TVHLLVQLMS KSSLHVHVWD
ALRRTRLLCV VVQTLGSQVR LQNLVLRSDY IQDYMRVIEL VSEANPRECM RYLIMEEFNF
SGIHSFLPLL MQLSLFSKEL DSYRFCIGSF VRTVSFLLSD ANNCRLLSRM NPSPIQMLIE
SLSNVPSDRY DAHLLILRGI LQILLYTSNF TKLWVEEFSL FSGPSVCLST IVQYCSHNED
PNTPLNEEST VLFDILSLLL SLPDSGRGSS YSLYLYLRAS HWESEDIEPD QSVYSATIGL
FGLRVILRAS LAAAEYRPTL FSYLAQLVIR AIRVGDKDIV IAGLISHSLV NVIARYIRMC
TEKENSNLGS VIMTIVRLST IVCSSSHMYT KQKHGADALC AFIVELVSSS SSRALTYGVQ
TVMTLASFHN EELFFTMLVS AHLFNELDKR LQWLFTSDEI LLVLELMHEV CIRVPSLQKE
MVPTLGTVIS LIRREVHSGP KLLLKCSELI SLVMLNSENN VSSVQVILQA FIMESDFQSS
GSIVSGCWGL QTCIKAVKGN ANVRTYFVSQ IENILTCLYR LCENMKNIFL SELKYYDLCE
LFNEILTHYR YQKDTTGTQK YKDKYLLQCD FLLLILHLLT LLQANAEEVS SKDLSSKLKW
TISQGPFLHC RLYTSIVVRA FISMSSVSSY AMFDEIFFLK EKLMIFPVTC QNLICEWKFQ
SSYGDNLFTY NMQRIVYPEY LQSLQGAIKE SSKTASSALL GSSITQLFIE IFSNSLENIC
LLVGLKTILL LAELFTIAID ENHTYMLTCF NQLVTVISQL GTCGIHQNTI FYLFQMCLRK
RNETFMEYDQ TSTRILLSTW RNLLHDSLPC SQPKFFFEIS IGFPTITIFH TPAINRVKRE
FNLHGGVDIP IQLTIPKPDN CISSVLWFLV ESNPSSLQQE GEFILLSHFF DQNKISLLLF
LSDRGKLKLR LTVRVNRQLR SKDVSIPNIR VPTCQWCMIS MSIFGNKRDK ASLLSKMHLN
IQISLYTTGN QFTPLLKEVM VHVEVSLGVF KSVDHLFQGL NMISMGMARV PVNDYPPQIL
FGSLGLFGGS LSKLEVALLC AMGSDNLFSF AFMDKNFVVS LYPMLANIVQ EEKEKKEEEE
EKKEEGFILT KEMILLSSMW IQQEIHNTDG QVVFSGTAFP FNKYYNKERM PLIVGISEDG
LYLRGNVERW GSPIDSMEKY DNDNITFFHI PSERLTKNVL ITSIPLRLSV NENNMDNNNN
NNNNNNNNNN NNNNNNNNMV LGVIWAKVNG PRFRYVSPLY SMLDAIGGIP FFSWLTSLQT
PCSDAFEEAW ECVCAIIQKH SAESLLSQLS SSHGGRCDNI VILLRTLLHK RIGISEKMAI
SLCKAIGYHM IVRTDLLPLM LDFTLWSKDV GAFRVILQKL QDYLKDKQYG YFNTQILRTG
IHSHYSSDDC YALEEFLLHL MMCCSNSDSD SNSNNNWDDS LISMAIQFII PLCETTFHLR
RIVQTVIFLV ISEEKPTRSA IEWALGLLGV VHSLLQLNRS VKLQEEDLAS DVVILLKCSN
EAIRCMALSL WSCIEISKEQ LDLMINEYFL RKDSSLDDNK LCLSKGELDI IISVIEQSTS
IGDTAQARKL LIFLIAFLLH MKDEFQIRVI TLLNHIIKTK GSLAYDLVFP SETGNNMEVS
LQRYLLGLLS RLKEDHTNMM KLLIELLTHI SLYMIEVSWS KEGKRCGDML CDVILIILKN
VWEPKCLDQN HHRRKLDIHK IYFVVHELYV PCLHTFALLA SKGFSESFAQ DYLLFLRTIG
SIVILLDSCE SDSIDFPEGM INHHTWTDQL LAKAYFTRFG KSLSLSGRHN GVCLALPLFE
CTHKLFFGLQ TQSFVTIMPK KRLNRLCEEL LLLQWKVVSS ILYNAEKNDD DIVRELILLH
LSHSGSIDYG FNYSTWEKQE MIVQPPSDSK WKYLLLSSNT LVLEVLKTSP GDVMKESAPW
LVVLRAASSL LHSSIQENTP QLSMALSLCR LIRFNSNIWS LIKGGVSPSS VMELDATLKI
DYQNSLDETS NNIWRESLWG IELTRNGVAA LEKSAIKSRN FAFSLLQRCG SHTPPTFITV
DPNRIVHHHG QTSMDKNQFE SYVYRSVTLY KKTIEEDGNA ILAAHAAYRF SLLPWWGYCI
HLYTQSTVPL NRWELDHFMG TEWQRIRLRR FIHNVRITDM RENTEDQFLQ PIYREDMRCS
SSSSSSIDDV KLLEIYSITA IPQLLTSRIE GRNVFRINCE LILPMDRISI ILNITSHNIS
YVVECFQNGL TELEKESEGI FLNEQEKKKS SILGKVYDPL AQLLKTFQSK HEIPCLQRVI
DISTVRAVWP RRNLLQPCAL ELLLSTGETL FIAFNSEEIK EQVSNTIRNV ARRYLDKKLF
LTDNNLSMWR NWWCEGRISN FHYLMFLNFA AGRSYGDLRQ YPVFPHVIAD FVSDTLDLTS
AASFRRFHKP MGAQTVDREQ KAIEKYNDIA TIAEGEGNSV SMDLMPHHYG SHYSPLGGAL
HYLVRVQPFT NYFVDMNSTL DDAGRVFDSM AAAYRISTGK DVKELLPELY CLPDVFINSN
CIPFGTKQDG VVVNNVQLPP WASTPRELTF MLREALESRY TSENLHFWID LIFGYKQRGK
EAVAAVNVFH PLTYEGSVDL FTITDPVLRS SHQTQIDCFG QVPLQLFTHP HKPRIKSTDS
IFIQSPCPTL RYNASHSKSC VILHPDKLIP VQYCKVDGTV IIFPRSKHTI TALGAEESGE
RKFSQSLSQT RPLVLPKNCL PFKVVNDQVK NYLSYRENCI LLLDGKDISR EISSFHVSNG
KINTFAVDSP TVYVGMESGA IHVIKINGEE WNEIELLMQD GNGEPINMID VAEKILHGES
KLTRVRGHVK RRVCVLYGHT ASVTSLSVSS EWGILVSSAE DNNVAVWDIN RYLLLRTISS
YPSISVRYQE SLLTKHIWQH RCQDENDWHY NLISVNAKEG DIILAGSSKN GGTHAVQLYS
LNGSFLASSE LANGPATALL SVGGVVFVGY GTSVRVLKEI NLQLICELTH PALEDCIESL
ALNPCGTLLA ACDRKATLVT WKVAS
//
