ID A0A1X0NZK1_9TRYP Unreviewed; 863 AA.
AC A0A1X0NZK1;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ORC89639.1};
GN ORFNames=TM35_000111730 {ECO:0000313|EMBL:ORC89639.1};
OS Trypanosoma theileri.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=67003 {ECO:0000313|EMBL:ORC89639.1, ECO:0000313|Proteomes:UP000192257};
RN [1] {ECO:0000313|EMBL:ORC89639.1, ECO:0000313|Proteomes:UP000192257}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Edinburgh {ECO:0000313|EMBL:ORC89639.1};
RA Kelly S., Ivens A., Mott A., O'Neill E., Emms D., Macleod O., Voorheis P.,
RA Matthews J., Matthews K., Carrington M.;
RT "An alternative strategy for trypanosome survival in the mammalian
RT bloodstream revealed through genome and transcriptome analysis of the
RT ubiquitous bovine parasite Trypanosoma (Megatrypanum) theileri.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the D-alanine--D-alanine ligase family.
CC {ECO:0000256|ARBA:ARBA00010871}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORC89639.1}.
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DR EMBL; NBCO01000011; ORC89639.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X0NZK1; -.
DR STRING; 67003.A0A1X0NZK1; -.
DR VEuPathDB; TriTrypDB:TM35_000111730; -.
DR OrthoDB; 167616at2759; -.
DR Proteomes; UP000192257; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008716; F:D-alanine-D-alanine ligase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR011095; Dala_Dala_lig_C.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR PANTHER; PTHR23132; D-ALANINE--D-ALANINE LIGASE; 1.
DR PANTHER; PTHR23132:SF28; PROTEIN WITH D-ALANINE--D-ALANINE LIGASE C-TERMINAL DOMAIN; 1.
DR Pfam; PF07478; Dala_Dala_lig_C; 1.
DR Pfam; PF00856; SET; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF64518; Phase 1 flagellin; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW Reference proteome {ECO:0000313|Proteomes:UP000192257};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 370..586
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
FT DOMAIN 607..699
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 707..723
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REGION 63..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 743..863
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..198
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 743..765
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 767..855
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 863 AA; 93082 MW; 52E47802CDB8B773 CRC64;
MFTFSMRRQG VVAVGSWTSP ASAVSLLRGP FHHYHLNNSG VFSLMILAPQ CWARRYRASQ
ATLTSSSRNS TGTRHHGNAG NASSSHTSVT SVSAGNGNSN SNGVSGGNHS SVAHTSGGNV
GTGSTTTHSH SSGGNGNNNN NNNNNSGGNG NGGSSHNSSS GGGGGVSMAQ AAKKKKNTRK
VLKRTTVLKK KKRIKKVLSS TKVSSPSGAT TLSRTTTAAS TGTGSTNVSS ATTSSTNSTT
TKTTSSHRLR RKTITKKPTP KFRICVLNSS YEGADSVTAD VDNYHCSPAH WVKDKKQFAF
TEVSVKKNDS YRQIRELVTS NKFDVFFNLC DGGRDEKRAG VDVVEALEEH NAAFTGTDSH
SFEPSKIDMK LLVGAAGVNT PNFVLLESAE GLAKKCRHLR FPVIVKHLSG YASVGIHKDN
RCDTLEELKT KVPKFLKEFN HALIEEFIRG REGTVLTCAD SGSQFGVKVF KPLMFKFLQG
DDDFAYFEKK WSMECNDEAY DFLPHNDPAY PQVVDMARNA FKHIMNGVGY GRVDFRIDPK
GDVYFLEINP NCGMWYSEKD GGDFADVMVQ GDKSWNHDRF IRNAVLRAVR EQVARRPWYF
ISHDSKGNFS TRASKTVRAG KGLFCDAAHP VPVIAQALYK LGEEDPTVGC VIMRGDRLHQ
AVAIRHSCEP NMQFMQGRTL TLVAKRKINV GEELTVDYAT LCDENMPAFA CSCGTSNCRS
VIFPAPPTPR TLEGKNVRQM MREKKKAWYK EKEDREAERM LKKRASKGKN NSNNSGNNSN
GGSGAGTGSG NNSSSSGNST NSNNNNNNVS SYSSSSSSAS SSGANGSMTS GVSARGNNAQ
TNNNVNNNTG SGEGATKGVS GRR
//
