ID A0A1X0P0H0_9TRYP Unreviewed; 227 AA.
AC A0A1X0P0H0;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Ribosome assembly factor mrt4 {ECO:0000256|RuleBase:RU364039};
GN ORFNames=TM35_000082000 {ECO:0000313|EMBL:ORC90402.1};
OS Trypanosoma theileri.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=67003 {ECO:0000313|EMBL:ORC90402.1, ECO:0000313|Proteomes:UP000192257};
RN [1] {ECO:0000313|EMBL:ORC90402.1, ECO:0000313|Proteomes:UP000192257}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Edinburgh {ECO:0000313|EMBL:ORC90402.1};
RA Kelly S., Ivens A., Mott A., O'Neill E., Emms D., Macleod O., Voorheis P.,
RA Matthews J., Matthews K., Carrington M.;
RT "An alternative strategy for trypanosome survival in the mammalian
RT bloodstream revealed through genome and transcriptome analysis of the
RT ubiquitous bovine parasite Trypanosoma (Megatrypanum) theileri.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the ribosome assembly machinery. Nuclear paralog
CC of the ribosomal protein P0, it binds pre-60S subunits at an early
CC stage of assembly in the nucleolus, and is replaced by P0 in
CC cytoplasmic pre-60S subunits and mature 80S ribosomes.
CC {ECO:0000256|ARBA:ARBA00004046, ECO:0000256|RuleBase:RU364039}.
CC -!- SUBUNIT: Associates with the pre-60S ribosomal particle.
CC {ECO:0000256|RuleBase:RU364039}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU364039}.
CC Nucleus, nucleolus {ECO:0000256|RuleBase:RU364039}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL10 family.
CC {ECO:0000256|ARBA:ARBA00008889, ECO:0000256|RuleBase:RU364039}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORC90402.1}.
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DR EMBL; NBCO01000008; ORC90402.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X0P0H0; -.
DR STRING; 67003.A0A1X0P0H0; -.
DR VEuPathDB; TriTrypDB:TM35_000082000; -.
DR OrthoDB; 23333at2759; -.
DR Proteomes; UP000192257; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR CDD; cd05796; Ribosomal_P0_like; 1.
DR Gene3D; 3.30.70.1730; -; 1.
DR Gene3D; 3.90.105.20; -; 1.
DR InterPro; IPR033867; Mrt4.
DR InterPro; IPR001790; Ribosomal_uL10.
DR InterPro; IPR040637; Ribosomal_uL10-like_insert.
DR InterPro; IPR043164; Ribosomal_uL10-like_insert_sf.
DR InterPro; IPR043141; Ribosomal_uL10-like_sf.
DR PANTHER; PTHR45841:SF1; MRNA TURNOVER PROTEIN 4 HOMOLOG; 1.
DR PANTHER; PTHR45841; MRNA TURNOVER PROTEIN 4 MRTO4; 1.
DR Pfam; PF00466; Ribosomal_L10; 1.
DR Pfam; PF17777; RL10P_insert; 1.
DR SUPFAM; SSF160369; Ribosomal protein L10-like; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU364039};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364039};
KW Reference proteome {ECO:0000313|Proteomes:UP000192257};
KW Ribonucleoprotein {ECO:0000313|EMBL:ORC90402.1};
KW Ribosomal protein {ECO:0000313|EMBL:ORC90402.1};
KW Ribosome biogenesis {ECO:0000256|RuleBase:RU364039}.
FT DOMAIN 126..196
FT /note="Large ribosomal subunit protein uL10-like insertion"
FT /evidence="ECO:0000259|Pfam:PF17777"
SQ SEQUENCE 227 AA; 25579 MW; 631334771533CAF2 CRC64;
MPKSKRAKIV PLTKTRAKTR EDKDELINRI REALDEYTDV YTFTLSNVRT NILQQIREER
KADSRLFLGN NKLIMIALGR DEATSQRPNL HKLCKFLVGT CGLLFTNLPK KEVKSYFAAV
GAQVYARTGQ TATHSLVLRA GPLPQFPHSM FDHLSRLGLP IKLDRGVIVL LQDTTVCEPE
DTLSAEAAQL LKLFGIQSAE FRIDLTSHWS NGVASKIASR KEEKQTE
//
