ID A0A1X0P454_9TRYP Unreviewed; 4339 AA.
AC A0A1X0P454;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Putative dynein heavy chain {ECO:0000313|EMBL:ORC91608.1};
GN ORFNames=TM35_000052040 {ECO:0000313|EMBL:ORC91608.1};
OS Trypanosoma theileri.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=67003 {ECO:0000313|EMBL:ORC91608.1, ECO:0000313|Proteomes:UP000192257};
RN [1] {ECO:0000313|EMBL:ORC91608.1, ECO:0000313|Proteomes:UP000192257}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Edinburgh {ECO:0000313|EMBL:ORC91608.1};
RA Kelly S., Ivens A., Mott A., O'Neill E., Emms D., Macleod O., Voorheis P.,
RA Matthews J., Matthews K., Carrington M.;
RT "An alternative strategy for trypanosome survival in the mammalian
RT bloodstream revealed through genome and transcriptome analysis of the
RT ubiquitous bovine parasite Trypanosoma (Megatrypanum) theileri.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORC91608.1}.
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DR EMBL; NBCO01000005; ORC91608.1; -; Genomic_DNA.
DR STRING; 67003.A0A1X0P454; -.
DR VEuPathDB; TriTrypDB:TM35_000052040; -.
DR OrthoDB; 168388at2759; -.
DR Proteomes; UP000192257; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.58.60; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF352; CYTOPLASMIC DYNEIN 2 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000192257}.
FT DOMAIN 1740..1886
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2030..2185
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2340..2464
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2687..3084
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 43..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3633..3654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1019..1046
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1112..1149
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2934..3007
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3136..3226
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3445..3472
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 43..58
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..73
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4339 AA; 496151 MW; C57D881E9DA6E36C CRC64;
MQRAGLVAVE SLLFSVAQRH LQVLFGASQI TRGDDCVLFE FPPTEQQSQS QQQSQQQGGG
EKEKEEEERW GNEVQRLCTA MVREVTGRTS LRLAGEEHET DFTSLKAHTI PFGKFMADVA
DLDTMPDSLD SPSSLLNLQH MLEVLYKDVV SDMKEGALLV THFPKAMCPT GVRLDVLMGK
SICMRVFSST EEELMPERVE LGIENASFLA GSLSTTQGFS HEGPLIKVWI DLRVLANAIS
SYSTAPIESE LPSQWRYKSF TLPEATEVLK IVHKALHSYW NRNPHNERTK VNAISLLSIV
SGDLREYIKS QILMESSDWQ GPWRMNLDHL EKSLSLIKEW NTMVRLLLKE EWKNWDGGKF
HDEILERFAA RLRDVIRIRQ LLESASKIMQ VKLQDSITPE VLFEGQSLTD NKITSEEQWA
ECMAKFEKEF SFLEDNLRGR VKQLFSLQQQ QQQQQGMESS IRLLQQHQAL LRRDGIRNGI
QKDLVAIADF LIQQLEQIRG RYENNRRRTT NELHLLRISK SCQTECALVT ENALKLFGMS
EELDKVVEAS KIILQEVQQS EQEVLTSWKQ NMEQQCKKIL DVADAFTIVS VDKKHMMCTL
HSSVKQFMQE IHTIRSWCGD NEQEGNKSSS SSFSQLSEEA EQTISSCERL VKAATRTMQI
VSNYNMVQGQ IMECTRPMLE GASTHARNQL FYTGSNTRSI SINNYNELEG LNMRFQNAVD
AMSNDNRRIR RFHYDFISQV IALYNVDLAR HMDQWRSAVD GMRSSFEDFL HTHRHEHCEK
WREHLDAQIY KVLEYQYRRG LESLHEKMEE FKVELVFKQG QVHFKPTFEA MREAYYVKLR
EFVGVPLRFR GLQAKRESGG PYEMYKVMPL FNKERILTVH TKAMELFAKL NRVRKAFRSY
VLVGACGVNG APDVDTLVEA IAKTMKHYSE GFNVIKEQTN KLHSIDDSMK IDCFMISTIP
IKATIEEQLH RLEESLINAI RKSLQRMLGD IDSFVFNASN VITRQPTTMD EVGQANKAYY
ELHETMSQYE TKLSQLEEMN KVLRQQSGTS IDLGATKSRW EHLREAMASH HKIIDASVSK
MRVSLDAMIQ KHMKDGQRFA SKWVKQKRQL VVAFEEKKLD HFKKALMELK DLYSELEDIR
KQGNDLESKC EYFKLPPPNF QQINETIKDA TQTAAMWELY DAFWESLEEL RKEDWLTFRS
HIYIFDDFIT EWKGKLSSGE KETQESSSGL IIIKYLSNLL EEWTTCVPLL RFVRGEGMMT
EHWNEMFRLL EIDKGMKSSE LTFGDIIDHY KQIITKEPEL KNLHARAQGE VQIRDALQDL
RVWALESTFT LITPTDNTTT STNSSSSSSV KVKLITDWKE TMTGVSENQA LILSLKDSPF
FSHFADEING WEVKLATLYE TLTLMNTIQR KWTYLEPIFA RGALPQEQAR FKRVDKEFVS
ILHEIEVDPR VMTIGSQSDI VDRLKTILEQ IERCQKSLIE YLETKRESFP RFYFISDEDM
LEILGHSKNP SVIQTHLKKL FMGIHSVLFS EDQKSITHMV SADKETVKLK NDISIEEDDV
EKWLIRLDAC MRETLQDLLF ECVKVKDLMS METIEMYPSQ ILQVAQQIHF AISIENAITS
NQLQSVGETL KKNLNQLTLT PVDANTVTML KVKALILDII HQLEIVELLE MKKVKTVKSW
WWQKQLRYYI SENQQCLVVM MDASFEYTYE YQGNAAKLVH TPLTDKCYLV LTKGMQLGYG
GNPYGPAGTG KTESVKALGS AMGRQVLVFN CDEGIDFKAM GRIFIGIVKC GAWGCFDEFN
RLKIDQLSAI SQMIQIIQEA IKNGESTCPL LNRTVQVNRN SGIFVTLNPA GKGYGGRTKL
PDNLKQLFRE VAMSIPDAEL ITSTMLLSEG FTHAKSISKQ IVELFRLSGQ LMSRQQHYDW
GLRSLKAVLR LAGSLMQTWK LNNKEKEITV AQEEEIILQS LNTNMLSKLA FEDVRVFRSL
TMGIFPHIKS NDISYGELET AVKKAIEDLQ LTLIPEQVAK VMQLYEALQQ RMGVVLVGPS
GSGKSTLFQI LRRSLQSLGV EVPLHVMNPK AMPRQQLLGY MDPDTREWYD GVLSAAAREV
VKCPREYRPW IICDGDIDPE WIESLNSVLD DNKLLTLPNG VRIQFGNNVN FLFETHSLTY
ASPATVSRMG VILLSERDID LELASHSFLV KETPERREFL LPLINKYIIP VLFEALKTEA
FPVSTTRMGI LKCSLMHVLP SVNEEDFVLS FMQGICGMLL PNGAQQIAAA LYEKSNLNPI
SSKRPLDTYY DRKKKRLVEH TADLRENITA DTLVESGALI HTADIQRLLS TIKPLLSNTM
GRPLFLLGPE GCGKSIVLQQ SVKDFKGVRT TVLHCSAQTT SLHLIQKLEQ LCTLASTNTG
HAYRPKEGER LVVILKNVNL PKPDKYGTVE LHAFLLQLFM YNGFYNSDLE WIGIEKIQFV
ASMDPTISAG RYEVTPRLLS IVSIVYMTYP SRSGILQIYT SYFSALLKSP SIGQENDYNK
GAGLAQYVIS VFDKIRRRFE GEEQAHCIFT PRSITKCVTN LLMYAMDTQT TTLPAVLAYE
SICTFADGLS RTEDRRRAEK IISDTLTTIG YSTPSKEDSN PIMFVSWFSE VDKKGIKPLK
GVPYETIAVE VERALVRYSR EFKHLNIHII QESLSWLTRV DRVLSRPFGR LILVGRPGVG
KRNSVCLAAY MLRMEVVTLN MVQGYNIKNF RQELRQLMQR VITQNEHLVL LLDEHNIVDE
RFLEMINSLV SSGEIPGLFS PEELETMFTP LREEASSEGY IGSIYSYFLL RVRRNLRVVL
SMDDQHELFL VRLQSNPGLL SNCDLLWMGT WSNETARAIC KKRLHHIIKR IEEDPSNKNF
HLHRELFAVH EGFGKDATPG RFQILMETYE SILRKKSENS EIDLKRLQAG LTKLHEAEES
VEKIQKDVKH KKEQVEIMQR EADNALTEIQ KKMEESKEQR DSATELQERL KNEHEEIIVK
RQKVEDELSG IKPSLEAARE AVNSIRSEQL NEIRSLKAPP EPVRDVLEGV LALLGVTDVS
WQSMRKFLGE RGAKERILDF DAQKVTPAIR ENVSRLLNQK STSFKPEVIH RASVAAAPMA
AWVKAMVDYS TILERIAPLS QQLQQLEKNQ KEGEEQLHVL KKKLKRIDEA VEELRKEFSK
KCKEAERLKD TLEKAQMELE KACNLLEKLS TEKTRWAQDI EKIELNNRLL PKRAIISAAF
MTYIAKETED IRLRYFKQWS NRLNFTSVET VTGFMRAESD LLEWKSEGLP GDDLSQENAI
AMLDAVQTPL IIDPANQAIE WVKVHLKNKN IITEVTSVQD ERFAHTLELA VRFGKTLLVM
DVDGIEPILY PILRKDLLSA GAKRIVQVGN KQVDWQDTFR IMLFTRRTDL LLPPGGAGLV
LEVNFSVTRF GLENQLLGVT IQHERPELEE QRVELVKKEE NLKLELSKLE VRLLNDLANS
HGDLLENTTL ISALNDIKTQ ASNITEALQQ SRALQVELDE KRDVYRPFAS KGSMIFFLVK
DMEKLNRMYH FGLNDFVGLF LESLDAYKET TDVNQKISEL TINFAQKCFF HVCRGLLECD
RLLFGIHLIH GLFPEKFPEP LWDLLVGAAK SNNTNNNNSS DAGNEEKKSG DEKIPSWVSL
PTARTKLITI NSDEVGSKHM QQWELQNTDR WVNWMRESAP EETLVKNESF SIMDQLLIID
TFRPDRLTDL LHHIIMYLLH LETLVPVTSL EEILGQGKSM MPIILITSRG ADPSLEVQEI
AFRLVGRKRF VQIALGGGQT EDAMLHLRRC AAQGDWLFLK NLHLVLDWAS VLEKELSAMP
TPNPDFRLII TTEPHDLFPT VLLRMSMKVT VETPPGIKQN LLQSYTIWDE SFINNKTKTT
CQVLFGLAWF HAILQERRNY VPQGWLKFYE FSSSDLKSAA ESLSILSSEK MDWTTVHGLL
QECIYGGRLE NKTDEKVLMT LISFVFNDDM LTSCKNKLYG NIFVPSTNVH NEIVQFIRDH
FPDSDNPSIL SLPDNAERVV KEHMATQLRE HLRSFANMSQ IGIKTTTETW RSLLGPVIEM
WNAYGSLVET HIPVISEDEK DLDPMYVFFV SEVGLLVNII DEVADIFTNL RSVIDGTLIP
SLTLREEATE LMGGRVPLRW LELMDGPREA TLWLSTLRHR LVTMIGYCKI TFSMSAGPFD
LLDFLRPRAF LNALRIFTAR TAGVPLVDLT LLVSPDSRVT HDLQVGITVK GGSIQLQGAI
LNERGEVEMA SASSPSSLAL KTDLKVGWVV AQNIKNLARI PLYTNAERVS HILDLNILCN
EEVQEKLLLG GVAAFLMTV
//
