ID A0A1X0P943_9TRYP Unreviewed; 419 AA.
AC A0A1X0P943;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Putative elongation initiation factor 2 alpha subunit {ECO:0000313|EMBL:ORC93398.1};
GN ORFNames=TM35_000012750 {ECO:0000313|EMBL:ORC93398.1};
OS Trypanosoma theileri.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=67003 {ECO:0000313|EMBL:ORC93398.1, ECO:0000313|Proteomes:UP000192257};
RN [1] {ECO:0000313|EMBL:ORC93398.1, ECO:0000313|Proteomes:UP000192257}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Edinburgh {ECO:0000313|EMBL:ORC93398.1};
RA Kelly S., Ivens A., Mott A., O'Neill E., Emms D., Macleod O., Voorheis P.,
RA Matthews J., Matthews K., Carrington M.;
RT "An alternative strategy for trypanosome survival in the mammalian
RT bloodstream revealed through genome and transcriptome analysis of the
RT ubiquitous bovine parasite Trypanosoma (Megatrypanum) theileri.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the eIF-2-alpha family.
CC {ECO:0000256|ARBA:ARBA00007223}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORC93398.1}.
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DR EMBL; NBCO01000001; ORC93398.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X0P943; -.
DR STRING; 67003.A0A1X0P943; -.
DR VEuPathDB; TriTrypDB:TM35_000012750; -.
DR OrthoDB; 4371132at2759; -.
DR Proteomes; UP000192257; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd04452; S1_IF2_alpha; 1.
DR Gene3D; 3.30.70.1130; EIF_2_alpha; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR003029; S1_domain.
DR InterPro; IPR044126; S1_IF2_alpha.
DR InterPro; IPR024055; TIF2_asu_C.
DR InterPro; IPR024054; TIF2_asu_middle_sf.
DR InterPro; IPR011488; TIF_2_asu.
DR PANTHER; PTHR10602; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1; 1.
DR PANTHER; PTHR10602:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1; 1.
DR Pfam; PF07541; EIF_2_alpha; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF110993; eIF-2-alpha, C-terminal domain; 1.
DR SUPFAM; SSF116742; eIF2alpha middle domain-like; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50126; S1; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000313|EMBL:ORC93398.1};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000192257}.
FT DOMAIN 133..204
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT REGION 395..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 419 AA; 47578 MW; 0BA4D66F6371F58F CRC64;
MTSYGVVENP EKVDYKVKCC CQTTDGVYFQ VPKDFFRLNA NLLRRKLLVA APFSVPLNTE
DFKQLLVLME ASIVSAAAAT VATDAPGGEE KQKPQWMKNL NKRQQKFVDA CLGISTWEGR
DVCFYEEKLP KENDVVWVKI IQVNDTSAVV QLLEYGNHEG IIPYTEITRL RIRAIGKVIK
VGKSEAAQVI RIDKDKGYID LSKKQVTLKE AKECEARFFK GNEVRSIVCH VADECGIPAT
QAMEMIAYPL YRREAGKHAW NWLQELNHTR DIEGILGPLK LPEKVQQVLL TTLEHSMRTE
ITTIHADIEM TCFQCDGVNA LREVLLIGRN FKQNEEPQIP ISVTIVGPPK YRLRAKTELK
EEGILRMKEA IETMKIEMAK RGGILKVVSG PYALGEEEHA KEERNDYQDD DDDDDDETD
//
