ID A0A1X0P9E5_9TRYP Unreviewed; 986 AA.
AC A0A1X0P9E5;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Mitochondrial DNA polymerase I protein A {ECO:0000313|EMBL:ORC93546.1};
GN ORFNames=TM35_000014230 {ECO:0000313|EMBL:ORC93546.1};
OS Trypanosoma theileri.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=67003 {ECO:0000313|EMBL:ORC93546.1, ECO:0000313|Proteomes:UP000192257};
RN [1] {ECO:0000313|EMBL:ORC93546.1, ECO:0000313|Proteomes:UP000192257}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Edinburgh {ECO:0000313|EMBL:ORC93546.1};
RA Kelly S., Ivens A., Mott A., O'Neill E., Emms D., Macleod O., Voorheis P.,
RA Matthews J., Matthews K., Carrington M.;
RT "An alternative strategy for trypanosome survival in the mammalian
RT bloodstream revealed through genome and transcriptome analysis of the
RT ubiquitous bovine parasite Trypanosoma (Megatrypanum) theileri.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORC93546.1}.
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DR EMBL; NBCO01000001; ORC93546.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X0P9E5; -.
DR STRING; 67003.A0A1X0P9E5; -.
DR VEuPathDB; TriTrypDB:TM35_000014230; -.
DR OrthoDB; 208079at2759; -.
DR Proteomes; UP000192257; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR CDD; cd08638; DNA_pol_A_theta; 1.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR019760; DNA-dir_DNA_pol_A_CS.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF27; DNA-DIRECTED DNA POLYMERASE; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR PRINTS; PR00868; DNAPOLI.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS00447; DNA_POLYMERASE_A; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000192257}.
FT DOMAIN 735..936
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 97..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..125
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..159
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..191
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..213
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..259
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 986 AA; 109533 MW; E7D468E4D5B1A443 CRC64;
MQKRQLHYPH HHHHFHHHHL QHQNYVPVTL THIRPVEEKS NTSSVGSSDN VQKWMAFGLN
KDVISSGSLG TLQLPATSPG GAVVVVEEEE AAGVVYSVEE DNNNNNNNNN NKEKRRSEND
EMDSSIRRQL IALSSRVGHA REEENCVATR RERRGKNTEQ TLHTNTTGIA NSNNNSGSSN
NSSSHDNNRN RKTNMSSGKK HNRESDGELG DHQPLVKRSA VTTTTTTTNR RKTIEEEGEE
EEEKGKKSST AEKKKKTSNR KTSTSAASKR QLKESTPPTL FSMPSDSSSE SRQVTISVPF
KEIDDNNINY LFNDIQDALS DQNRIQAPTL FVAFITHEGD TNFSISANTN GKVHFVRGVN
PEMSHLKIKS FILRWKDEVL VIPSTPGLTF LVRVLEELPG VEIVTFNAPS LLLLLLSYRQ
GKLFTSCISD IRLMAWMLQT SEGSDAFTDY DVLLHSSHQQ IGLSAGFRNV IGCSLKQIVC
HRVYYMVPLY RSLYGQLGTL GLLPAFLKQE KRISLLCASM KLNGFTVNMS EVEGFKLRCA
SKMEELQASA QKLLPSMPDF NLQNLDECRI AIYEVLRLGT YLTHTESDGS SSCAVTVTKS
GKLSTSEETL KLLASHHEFP RILIAYRKAA KLLQTYTVGM METAIPLVND EGEFTDRCIT
DGGNTNTSEK KLGNEKTVSD SSIKWVKLYP NFIQEGTDTG RLSCVEPNLQ NLPRPRVIDV
DDARVAHEAE MASFRRCFAA PAGCTLLSVD YEQIELRVLA HLSADAALVE ALTHATDIHR
AIAETLFRKS PVSGDERALA KRAVFGTLYG AGPRTLAAQM GVPLERAMRV AALFRAAFPH
VAEFHRRVIA QCRADGGVRT LSGRRRRLQD IDDRVMGRRA GAERQAFNTV VQGSAADVVK
LGMLAVEREV LRPHAGEVKL LAQIHDELVL AIPTDMLQRI VPLVTQSMAH AVSLLVPLRV
TAKVGRSLGE MEEWSVDHDL GIREIP
//
