ID A0A1X0P9Y8_9TRYP Unreviewed; 289 AA.
AC A0A1X0P9Y8;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 22-FEB-2023, entry version 15.
DE RecName: Full=glucose-6-phosphate 1-epimerase {ECO:0000256|ARBA:ARBA00012083, ECO:0000256|PIRNR:PIRNR016020};
DE EC=5.1.3.15 {ECO:0000256|ARBA:ARBA00012083, ECO:0000256|PIRNR:PIRNR016020};
GN ORFNames=TM35_000016210 {ECO:0000313|EMBL:ORC93744.1};
OS Trypanosoma theileri.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=67003 {ECO:0000313|EMBL:ORC93744.1, ECO:0000313|Proteomes:UP000192257};
RN [1] {ECO:0000313|EMBL:ORC93744.1, ECO:0000313|Proteomes:UP000192257}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Edinburgh {ECO:0000313|EMBL:ORC93744.1};
RA Kelly S., Ivens A., Mott A., O'Neill E., Emms D., Macleod O., Voorheis P.,
RA Matthews J., Matthews K., Carrington M.;
RT "An alternative strategy for trypanosome survival in the mammalian
RT bloodstream revealed through genome and transcriptome analysis of the
RT ubiquitous bovine parasite Trypanosoma (Megatrypanum) theileri.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate;
CC Xref=Rhea:RHEA:16249, ChEBI:CHEBI:58225, ChEBI:CHEBI:58247;
CC EC=5.1.3.15; Evidence={ECO:0000256|ARBA:ARBA00001096};
CC -!- SIMILARITY: Belongs to the glucose-6-phosphate 1-epimerase family.
CC {ECO:0000256|ARBA:ARBA00005866, ECO:0000256|PIRNR:PIRNR016020}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORC93744.1}.
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DR EMBL; NBCO01000001; ORC93744.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X0P9Y8; -.
DR STRING; 67003.A0A1X0P9Y8; -.
DR VEuPathDB; TriTrypDB:TM35_000016210; -.
DR OrthoDB; 915361at2759; -.
DR Proteomes; UP000192257; Unassembled WGS sequence.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-UniRule.
DR GO; GO:0047938; F:glucose-6-phosphate 1-epimerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd09020; D-hex-6-P-epi_like; 1.
DR Gene3D; 2.70.98.10; -; 1.
DR InterPro; IPR008183; Aldose_1/G6P_1-epimerase.
DR InterPro; IPR025532; G6P_1-epimerase.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR014718; GH-type_carb-bd.
DR PANTHER; PTHR11122; APOSPORY-ASSOCIATED PROTEIN C-RELATED; 1.
DR PANTHER; PTHR11122:SF39; GLUCOSE-6-PHOSPHATE 1-EPIMERASE; 1.
DR Pfam; PF01263; Aldose_epim; 1.
DR PIRSF; PIRSF016020; PHexose_mutarotase; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|PIRNR:PIRNR016020};
KW Reference proteome {ECO:0000313|Proteomes:UP000192257}.
FT ACT_SITE 155
FT /evidence="ECO:0000256|PIRSR:PIRSR016020-1"
FT ACT_SITE 259
FT /evidence="ECO:0000256|PIRSR:PIRSR016020-1"
SQ SEQUENCE 289 AA; 32496 MW; 64AF75DAA26A034C CRC64;
MTDNSVVVAK HEDGSSVTVH LQGAHITSWR NSNGEELLYT SPTAVYKEGV PIRGGVPIIF
PQFSNSGPLP SHGFARVRQW NKQQVQSGMA SFTLDVDPRE MQHSHSEKAE ENTTASTGVV
SLLYTITFSN DQLQLQMKIV NNDSASDVEF TFAFHTYFAV DDIEQTLVNG VNLTPYIDSL
SKERKVRHPE QFWGFMGEVD RIYLNQRCAV MLLDMSKKRT THIAGVNLPD VVLWNPWVEK
SAKMKDLPPD GYKKFVCVEH GAIGKKVKIP PKGEWKASQQ ILRFSCLKL
//
