ID   A0A1X0PAL3_9TRYP        Unreviewed;       566 AA.
AC   A0A1X0PAL3;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Metal transporter CNNM4 {ECO:0000313|EMBL:ORC93663.1};
GN   ORFNames=TM35_000015400 {ECO:0000313|EMBL:ORC93663.1};
OS   Trypanosoma theileri.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=67003 {ECO:0000313|EMBL:ORC93663.1, ECO:0000313|Proteomes:UP000192257};
RN   [1] {ECO:0000313|EMBL:ORC93663.1, ECO:0000313|Proteomes:UP000192257}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Edinburgh {ECO:0000313|EMBL:ORC93663.1};
RA   Kelly S., Ivens A., Mott A., O'Neill E., Emms D., Macleod O., Voorheis P.,
RA   Matthews J., Matthews K., Carrington M.;
RT   "An alternative strategy for trypanosome survival in the mammalian
RT   bloodstream revealed through genome and transcriptome analysis of the
RT   ubiquitous bovine parasite Trypanosoma (Megatrypanum) theileri.";
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ORC93663.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; NBCO01000001; ORC93663.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1X0PAL3; -.
DR   STRING; 67003.A0A1X0PAL3; -.
DR   VEuPathDB; TriTrypDB:TM35_000015400; -.
DR   OrthoDB; 248389at2759; -.
DR   Proteomes; UP000192257; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0010960; P:magnesium ion homeostasis; IEA:InterPro.
DR   CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR   Gene3D; 3.10.580.10; CBS-domain; 1.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR   InterPro; IPR045095; ACDP.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR018490; cNMP-bd_dom_sf.
DR   InterPro; IPR002550; CNNM.
DR   InterPro; IPR044751; Ion_transp-like_CBS.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   PANTHER; PTHR12064:SF81; CNNM TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR12064; METAL TRANSPORTER CNNM; 1.
DR   Pfam; PF00571; CBS; 1.
DR   Pfam; PF01595; CNNM; 1.
DR   SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   PROSITE; PS51371; CBS; 1.
DR   PROSITE; PS51846; CNNM; 1.
PE   4: Predicted;
KW   CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW   ProRule:PRU01193}; Reference proteome {ECO:0000313|Proteomes:UP000192257};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW   ProRule:PRU01193};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW   ProRule:PRU01193}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..566
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5013230490"
FT   TRANSMEM        43..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          41..224
FT                   /note="CNNM transmembrane"
FT                   /evidence="ECO:0000259|PROSITE:PS51846"
FT   DOMAIN          242..303
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
SQ   SEQUENCE   566 AA;  62527 MW;  210B88423048403B CRC64;
     MKSFFPLWTA IIVAIAATTA VMRVVDAAVE KEEGEEEETM NGVQWAYLII ADGVLLLFAA
     LFAGLTLAIM GLDTLSLEII ADSGSEPDKT YASKILPIRR LGNQLLCTLI LGNVMVNTLI
     AQITDSHIHG WVATIVSTAL TTVGGEVLPQ ALMSAHALQV GSKSVPIVKF FVLLFYPVCK
     PLSVVLDRFI GTDPGQIYER NELKKLMFMH AARGSESGLG EREVDLMMGA MELHEKTVMD
     VLRPISGVLM LEASEPLNEE TIQLISERGH SRIPIYQGDK NNIIGVLFAK DLLMVDPREN
     TPVLLLVKFY NRRCHIVPSE TKLISMLNYF QTGKSHMALV QEVQQRPYGD PYYEVKGLVT
     MEDVIEELIH SEIFDEYDTD PQLSFPAPQI PMKRQVGLTP KCSRRINMSA NQLKASALFL
     WESLPDLNRY SRGAGSVLSQ AISLHGAVYR VHPPPDARGL DQEDKANIWL YRSGMPSDVF
     TLVVTGKVEV FAGKEEIRME LPSWSILAAD ALTNQLYIPN FSCRVVQDSV LLQITRTSYQ
     DILAMLPGSC CVSSSGDPLP LGTNGN
//