ID A0A1X0QCI9_9MICR Unreviewed; 711 AA.
AC A0A1X0QCI9;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=DNA replication licensing factor MCM2 {ECO:0000256|ARBA:ARBA00018925};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=MCM2 {ECO:0000313|EMBL:ORD97529.1};
GN ORFNames=HERIO_602 {ECO:0000313|EMBL:ORD97529.1};
OS Hepatospora eriocheir.
OC Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Hepatosporidae;
OC Hepatospora.
OX NCBI_TaxID=1081669 {ECO:0000313|EMBL:ORD97529.1, ECO:0000313|Proteomes:UP000192356};
RN [1] {ECO:0000313|EMBL:ORD97529.1, ECO:0000313|Proteomes:UP000192356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GB1 {ECO:0000313|EMBL:ORD97529.1,
RC ECO:0000313|Proteomes:UP000192356};
RX PubMed=28345194; DOI=10.1111/1462-2920.13734;
RA Wiredu Boakye D., Jaroenlak P., Prachumwat A., Williams T.A., Bateman K.S.,
RA Itsathitphaisarn O., Sritunyalucksana K., Paszkiewicz K.H., Moore K.A.,
RA Stentiford G.D., Williams B.A.;
RT "Decay of the glycolytic pathway and adaptation to intranuclear parasitism
RT within Enterocytozoonidae microsporidia.";
RL Environ. Microbiol. 19:2077-2089(2017).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORD97529.1}.
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DR EMBL; LVKB01000019; ORD97529.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X0QCI9; -.
DR VEuPathDB; MicrosporidiaDB:A0H76_2943; -.
DR VEuPathDB; MicrosporidiaDB:A0H76_567; -.
DR VEuPathDB; MicrosporidiaDB:HERIO_602; -.
DR Proteomes; UP000192356; Unassembled WGS sequence.
DR GO; GO:0031261; C:DNA replication preinitiation complex; IEA:UniProt.
DR GO; GO:0042555; C:MCM complex; IEA:InterPro.
DR GO; GO:0005656; C:nuclear pre-replicative complex; IEA:UniProt.
DR GO; GO:0043596; C:nuclear replication fork; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR GO; GO:0006279; P:premeiotic DNA replication; IEA:UniProt.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 3.30.1640.10; mini-chromosome maintenance (MCM) complex, chain A, domain 1; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR008045; MCM2.
DR InterPro; IPR018525; MCM_CS.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR027925; MCM_N.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR PANTHER; PTHR11630:SF44; DNA REPLICATION LICENSING FACTOR MCM2; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF14551; MCM_N; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR PRINTS; PR01658; MCMPROTEIN2.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00847; MCM_1; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000192356};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 315..520
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
SQ SEQUENCE 711 AA; 80440 MW; 394A60F878BF225B CRC64;
MQRRRTEENE FNFDGSDSDS IILGSELHTL ASIVNDDRSI EVNNQNENLE DIDLLNELLT
FVNSNYSRVI RNMAAKNLES IEIDYRDLIR FDLFIEQPEK FLDILSESLT KVTNQYFPSY
YQIKSKIYPR VVNVPVVDEL RGLRNVHLNK MVRVQGVVTR RSGVFNLFSL VKYICNKCKA
SIGPFYHNSR TAPSIKCVEC QSSSSFTVDV TETVYRDFQK ITIQEIPGTV PPGSLPRSKE
IYLFNDLIDF SKPGDEVDVC GIYKNDFSPY LNLKNNFPVF STMIIASSVS KKINKMEMTN
EDVKEIIELS KDSNILERLI NSVCPSIHGH KNIKTSILLA MVGGNSKQNN SLRIRGDINV
LLLGDPSMAK SQFLRYINVI SHRAVMATGQ GSSGVGLTAS VRRDPMLKEW TLEGGALVLA
DQGICCIDEF DKMNEIDRTS IHEAMEQQSI SISKAGIVAS LHARCSVVAA ANPIKGKYNS
ALSFSQNVNL SDPILSRFDL LCVVKDNIDE IEDSKIADFI IKNHKMGNNE EETDINQDLL
KKYILYAKNN IVPIIASFDI KKITRLYSDL RKESLHSGIP ITARHIESIV RISEAFAKLR
MSSTVSKTDI NSAIDITLNT FLSAQKYSIA KTLRKKFAKY FEENNEDLII YLLKKMITEK
VTVTGEGSIN VNEFIQYCKF NEVIVTDNFY KSDTFIKSGY QIENNVIIKR N
//
