ID A0A1X0UQD1_9NOCA Unreviewed; 498 AA.
AC A0A1X0UQD1;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Glutamate--cysteine ligase {ECO:0000313|EMBL:ORI22537.1};
GN ORFNames=BJI47_18100 {ECO:0000313|EMBL:ORI22537.1};
OS Rhodococcus sp. 1168.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Rhodococcus.
OX NCBI_TaxID=2018041 {ECO:0000313|EMBL:ORI22537.1, ECO:0000313|Proteomes:UP000192546};
RN [1] {ECO:0000313|EMBL:ORI22537.1, ECO:0000313|Proteomes:UP000192546}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1168 {ECO:0000313|EMBL:ORI22537.1,
RC ECO:0000313|Proteomes:UP000192546};
RA Nahar A.;
RT "Metabolic and lipid synthesis pathways analysis of sub-Antarctic
RT Rhodococcus luteus.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-
CC cysteine + H(+) + phosphate; Xref=Rhea:RHEA:13285, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:35235,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58173, ChEBI:CHEBI:456216; EC=6.3.2.2;
CC Evidence={ECO:0000256|ARBA:ARBA00029283};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORI22537.1}.
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DR EMBL; MKKY01000042; ORI22537.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X0UQD1; -.
DR OrthoDB; 240589at2; -.
DR Proteomes; UP000192546; Unassembled WGS sequence.
DR GO; GO:0004357; F:glutamate-cysteine ligase activity; IEA:InterPro.
DR GO; GO:0042398; P:cellular modified amino acid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.30.590.20; -; 1.
DR InterPro; IPR006336; GCS2.
DR InterPro; IPR014746; Gln_synth/guanido_kin_cat_dom.
DR InterPro; IPR016602; UCP012666.
DR PANTHER; PTHR36510:SF3; CONSERVED PROTEIN; 1.
DR PANTHER; PTHR36510; GLUTAMATE--CYSTEINE LIGASE 2-RELATED; 1.
DR Pfam; PF04107; GCS2; 1.
DR PIRSF; PIRSF012666; UCP012666; 1.
DR SUPFAM; SSF55931; Glutamine synthetase/guanido kinase; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:ORI22537.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000192546}.
SQ SEQUENCE 498 AA; 55656 MW; 0618DC0176F4083C CRC64;
MGDDVEQRKF TREDRHRFRQ KVQDCLDALA TMLAQETFEV GQPQIGMEIE LNLVDDAMAP
AMANATVLDA IADPDYQTEL GQFNIEINVE PRPLRGSSIE DLERDLRTSL NAADERARAS
GSRLAMIGML PTLTEKHFEH RWLSANPRYD LLNQQIFAAR GEDIELDILG VRLPGADSAE
KLSTITDTIL PEAACTSVQL HLQVAPEDFA SHWNAAQALA GVQVALAANS PFLAGRALWH
ETRIPLFEQA TDTRPKELVN QGVRPRVWFG ERWITSIFDL FEENSRYFPA LLPVCSDEDP
LAALAEGFTP NLSELRMHNG TVYRWNRPIY DRSSGGHHIR LENRVLPAGP SIVDTLADAA
FYYGTVRSLA DADRPLWSQM SFDAAEENLH SAARGGFDSR LYWPEVGSVS PQELVLRRLL
PMADAGLAAY GVDVAVREKY LGIIEGRCLA RRSGSVWQRE AVVARERAGE DRQSALAWML
GDYVTLMNEG EPVHTWSF
//
