ID A0A1X1BGZ0_9APIC Unreviewed; 2067 AA.
AC A0A1X1BGZ0;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 08-NOV-2023, entry version 28.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=mcm5-a {ECO:0000313|EMBL:ORM39371.1};
GN ORFNames=BXIN_3012 {ECO:0000313|EMBL:ORM39371.1};
OS Babesia sp. Xinjiang.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC Babesiidae; Babesia.
OX NCBI_TaxID=462227 {ECO:0000313|EMBL:ORM39371.1, ECO:0000313|Proteomes:UP000193856};
RN [1] {ECO:0000313|EMBL:ORM39371.1, ECO:0000313|Proteomes:UP000193856}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Xinjiang {ECO:0000313|EMBL:ORM39371.1,
RC ECO:0000313|Proteomes:UP000193856};
RX PubMed=27784333; DOI=10.1186/s13071-016-1846-1;
RA Guan G., Korhonen P.K., Young N.D., Koehler A.V., Wang T., Li Y., Liu Z.,
RA Luo J., Yin H., Gasser R.B.;
RT "Genomic resources for a unique, low-virulence Babesia taxon from China.";
RL Parasit. Vectors 9:564-564(2016).
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|RuleBase:RU004070}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORM39371.1}.
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DR EMBL; MBFZ01000215; ORM39371.1; -; Genomic_DNA.
DR VEuPathDB; PiroplasmaDB:BXIN_3012; -.
DR OrthoDB; 5476523at2759; -.
DR Proteomes; UP000193856; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR002937; Amino_oxidase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR018525; MCM_CS.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR PANTHER; PTHR11630:SF42; DNA REPLICATION LICENSING FACTOR MCM5; 1.
DR Pfam; PF01593; Amino_oxidase; 2.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00847; MCM_1; 1.
DR PROSITE; PS50051; MCM_2; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004070};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004070};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022806};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004070};
KW Reference proteome {ECO:0000313|Proteomes:UP000193856};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00146}.
FT DOMAIN 1192..1244
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 1672..1877
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
SQ SEQUENCE 2067 AA; 233331 MW; 8342240D99C0A2EF CRC64;
MNRDRRLHIL RWIFLYHSLT ADQQRELLNS IGEPCFPDYT NDTNFVLSID RPAYVRFYNI
ALALRDRFLC RFVRLAWNKL GVALKLKLVI RASDLYDSDP GVTRKRLDVL CGADNYRPTT
GTYEKSILVR YGSVSSCYME LLDHRNMLFI SLGMRPPDDC AKGFICPDRP SLLNPSANFG
FQELMTQLFG SNKDLVLRCD ILNNHNGNVG DPMSVDFPRE LQSSVSTPEE AKETTDCECH
WNMDKIQQVL HSEYPRSDVN KKFYNQFDNL VIRDTEVVVV GAGISGLSAA SYLMSCGADV
VVIEGRDRVG GRACTTYFPE KKLSGETIPA VHIDLGANYL HCCNPLDFEG RKRKSEPVKD
VRSRRSNFKS LLGLSLHLRP NVADVAGGAN WESTVYSRWS DLEGQAIDMD SIVKANMIAE
KIRVRAARKV SVMKKHMKNV ASNGKISNRS KHLWYVREGL YREIFNRPPD TTAVSHPDAY
DFSLSSSALS LPQPVTTGLF EERSPVLPTM FPVPCVSQHG YYGNTSLWVQ GQTVMPHCRG
SLGVVGSHPY VFPLNPQVAR SEPPRSKTSP CTNGGVYVEQ SYRYGSPPPG CALPLDRPLI
INTFDKTKEW NAYDVMDKLL KNTPLGVARY IDVKSKCDSM AYLFDHDGNR KSLWDIYIES
ITEIFRENGL SPNNLSEKEW SMIFVILQSR IGYNSDLRET CISMCRLPNV DEDFDESSFY
LSKDNLILSK EFVLGNYVEQ TTVKKRPFES KNDSDKLVID GWDWLLNTIT NGVEHAIYLN
SCVSHIDVSV GDHEYPVSVH VSSSIDSTRP SKLIRAKYAI VAVPNSMISP FPTRREHPNQ
IVFTPPFHPH KTTALQRYKM GHHNKVIMRF RDEDIFWTSD SPQLNTLDPR FQFLDLNMYG
KRGCILAHSF PPYSVTWDTH MSDAEIVRQC LEVLRNSFGI DMASMPYPID AMVTRWYRDP
FSMGSYSYPS LNAVDDDIIH LKSPHPAEFP RVLFAGEYLS SSYYQCVDGA YDTGMRAAED
VAHLGLNKPY PFPVTPDTPS LDGLFNPVMK EKYLGLSVPL PSADLFGYYL TDGSDDRISD
DEFDVESRGL PTCYSEELSL LENVQKLVDL DTVSVDKYCE DLRAVQSGLE ALHVRKHWNL
ALKSALNIVK SVLCIFTESS VEASKTMHNM RSPSTADAIL KAFVSYEGIN HEHLCHLCLA
GGEVVICDSS SCTKVWHADC VPSSCDQPVT DSTLSWLCPC CRGIDIPRGQ YRVAMPVTQY
WLRRGIWWCV KTLMIQCRNV YERIIYLRRR MFGLQEGTVY NSHGGQNVSD EVLNIPSSLP
SLDDVYTYFS LFLNSYSADS LQQGKLKRLL LENIKNNKYL LEVKLDDLFQ FQNIVENNPN
REDDSIAHRL KNLQMNRPDG AKFAADSGRA PPPTYAGDLV RVLTERPLIY LSTIERACYD
VCKLHHKFEE EDDSFHFIQI NLLNTFCRPT PIRALLAAKQ ERFVVVPGII VQAYRPQHKM
KTMTIQCRFC DHKMKLDVPL WISKPQIPRS CRYAATLRAT GGENANVDNQ LGCFKAQNPY
VVLPNECQFV DVQTLKLQEL AEDVPTGDMP RHLQLNVTRY LCDKMIPGDR VMVHGVLTNH
NVSAGGTEAN VIGNSYLHVL GIEKLTQGKG ESVSFDLEET NDLVLLATQP DIHDKIFRSI
APALYGMENV KKAVACALFG GSRKEVGSES RVRGDINILM LGDPSVAKSQ ILKFVDHVAP
ISVYTSGKGS SAAGLTAAVV RDRMGVFSLE GGAMVLADGG VVCIDEFDKM GEDDVVAIHE
AMEQQTISIS KAGITTMLNT RCAVIAAANP TFGSYSDDRE TSEQHEFKTT ILSRFDLIFL
LRDKENVRRD TTLCKHILSL HANQTQAENC PISMQKLRRL IQYAKQAVSP MLSSDAKDTL
RNFYVQKRRE YREDKRNATK KIPITLRQLE SLVRIAESFA RMELSPVSTD KHVQMAIELF
MVATGETMKQ TIAVEVMGPH EQLMVKQVED YILHRLPTGH RLSRRFLIRD MENRGFAIPH
ISKALAILIK RGTIQERGDL SLRRVAA
//
