ID A0A1X1BJJ7_9APIC Unreviewed; 2072 AA.
AC A0A1X1BJJ7;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=BXIN_2012 {ECO:0000313|EMBL:ORM40295.1};
OS Babesia sp. Xinjiang.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC Babesiidae; Babesia.
OX NCBI_TaxID=462227 {ECO:0000313|EMBL:ORM40295.1, ECO:0000313|Proteomes:UP000193856};
RN [1] {ECO:0000313|EMBL:ORM40295.1, ECO:0000313|Proteomes:UP000193856}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Xinjiang {ECO:0000313|EMBL:ORM40295.1,
RC ECO:0000313|Proteomes:UP000193856};
RX PubMed=27784333; DOI=10.1186/s13071-016-1846-1;
RA Guan G., Korhonen P.K., Young N.D., Koehler A.V., Wang T., Li Y., Liu Z.,
RA Luo J., Yin H., Gasser R.B.;
RT "Genomic resources for a unique, low-virulence Babesia taxon from China.";
RL Parasit. Vectors 9:564-564(2016).
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORM40295.1}.
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DR EMBL; MBFZ01000058; ORM40295.1; -; Genomic_DNA.
DR VEuPathDB; PiroplasmaDB:BXIN_2012; -.
DR OrthoDB; 211439at2759; -.
DR Proteomes; UP000193856; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:1902975; P:mitotic DNA replication initiation; IEA:InterPro.
DR CDD; cd05776; DNA_polB_alpha_exo; 1.
DR CDD; cd05532; POLBc_alpha; 1.
DR Gene3D; 2.40.50.730; -; 1.
DR Gene3D; 3.30.70.2820; -; 1.
DR Gene3D; 6.10.10.100; -; 1.
DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR042087; DNA_pol_B_thumb.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR045846; POLBc_alpha.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR NCBIfam; TIGR00592; pol2; 1.
DR PANTHER; PTHR45861; DNA POLYMERASE ALPHA CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR45861:SF1; DNA POLYMERASE ALPHA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 1.
DR Pfam; PF00400; WD40; 3.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00116; DNA_POLYMERASE_B; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000193856};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT REPEAT 107..138
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 208..249
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 968..1252
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 1328..1788
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
FT REGION 421..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 515..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 540..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 669..696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2072 AA; 235618 MW; 0CBE5BCF3C92AD25 CRC64;
MPLVFLPQIL WHSKDNKHCD RVYSLDFQPQ VVDYSNGVKS VFKLATGGAD EFVHIWQVSI
HNNAPQYATH SDKSILAPEN LRANATAGQS KSDCDVQPFT VKILARLVGH IGEINAVRWN
PNGVVLASGG EDRCVFLWAK SEGSNNTLDG TSQDYEEHYS RFQYYRLSHV INSISWCPDG
RLLAVSTEDG HVTLIDTFVE GSGKIRHFEG HTSFAQGVSI CPKNIMIASM GQDQTLRIWK
RRNEKQWKNI LVLRSAKDRS EFKESIGMES DDVRYSRSVF MNEELSTFFR RLDWSPDGRF
LVTPAGIRHN SLFRKEDEPE IKGDSVYTLY VFHRKLIHLG IPMVTHQSPT GPFVVVKFCP
LDIGKIEKEK INFFNKMFKP MGKVAKKKVS KPKKSKAASG VNGQLGVANT ATIAESFGRI
STSSDPGCDV SVKEAEPTEA AASPADATST STNLENDISI KEEVEDHSTA LSGSEPVCSQ
VDSGESIPVL HLIKNEDNID LTQEMVSEAI ECDMPSERAE AEDSDSRALR TSKREIKKPE
FYDATFEPRK SSRGGCKSKK SKKDEDKEYD TDVEDEVHIF FKVLFVYFAA LKRAFNDRIT
MDKSRSSAVS SALSKIRKHR EGVANALEEY EIEDENEKIY EVVTAEEYKD RTSKRRLDEF
IEGGEIFSDD DYDYESESGE DDHERPATKR QLPDGYGKSI EQHFTEIARK ESMAYRPPKD
AQSDKKLMEK LSRFEDDLDN EDIATSTSYA TMPGKMPMSM GMGMPPVMGM PYGPMGHFQR
FPQYQMYSQL DRQHPEEQLA APVEHKAAPL SQRPAEEPKL DVNVMTSGMD IDEIVQEAEK
MPFVPPLELD ASIVADFGEV DTTELEVITT SSARDVIVPE FEKAIDTESE GFAFYLLDVH
EDAGGLLRLF GKLHRGNTTE SCVVTVRQFM RCLFFKARMD LDLGNMPEVE SSYERAFMKQ
FFTEFEAIRK SYGIKKTKYK IVKRKLLRYG PSEEGLYVKV CYPFSHPQLR AEHYHGQTYE
DVYGATTTPA ELFLIKRKIK GPSWLRIIDA HPSTEKVTTC KHELDVESHK NVELWNARNS
EELPMPTLCV ASVSVKTFFA SPTHQEVLQV AMIYDKNFRL DTTEIKQLNK CTQHIGIRKI
EKLTWPSELN TFLKKRPYFR IFEHERGLLA NFMKTLEVID PDVVVGHDVT QNVSEFLLKR
CNMLNIPLRV SFSRMKATKK YNHPFCAGRI FCDTRLVTKE LYHNRSNYDL SSCVSDLVYS
MQVKEHPLYT KQSFNLKELI PCFAEESMKE LMTLVQANSK CALDAFNLLI KLQALPLTKE
LTNIAGNLWS RSVQCARSER NDFLLLHEFH KAKYIIDHNF ERYHKHTVAT ADNEKEEGDS
KKKNYEGGLV LEPITGLYDN FILLLDFNSL YPSIIQEFNV CFTTMQLVDD DTAEMVTDSP
GMLPQILRRL VELRASVKAA IAVERNEVRK AQLGVRQLAL KLVANSLYGC LGSVYSRFHA
RHMAAYITQQ GRMVLQSTRE RVEKQYSLRV IYGDTDSLMI DTNIRDEGSE SAYEAAQQVA
NTLMTSINKS HKKLEIGMDA MFNRLLLLKK KKYAALKVVD YKTRTFAREI KGLDFIRRDW
SILTKEVGNA LLAIILSDKT SESESHGVEN TVERIHDTLR EVNARIEEGK IPAKAWIITR
QLAKNPNEYG SNANLPHVTV ALRMNESGAT YSAGHEVPFI ICSKESIAKH MLSEACDNVE
SKESLESKLR SLCNRAYSLV EFQQKGLEPD IHYYKAQQLL PPILRLCGVI DGTDPQKLAS
CLQIQDEVNK TILNTYYGSF DYAEHESKAL SLINRTDERY REVEVTTSVP CQFCNSAVPA
NYFLKHMTCS NCTNWLPLHS MRNWISRTIY EISLQSSFCI RICNICNTTT PNVCIGDNDV
CPQPTCQSRD AMEVVLPASK IYLYYEYLIY MLEGALVHEG GIEKEDTLVN VTVDINGKMN
VLPSHSPFRK VRLFRDILDG TIRRSNLPAT SGFRVCGQYI LGILEALPFM QYHTVDYKVE
REELCQFVKD LQQRNAYSVV SLSDIFDTLT VS
//
