ID A0A1X1BMI8_9APIC Unreviewed; 644 AA.
AC A0A1X1BMI8;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 08-NOV-2023, entry version 26.
DE RecName: Full=RuvB-like helicase {ECO:0000256|RuleBase:RU363048};
DE EC=3.6.4.12 {ECO:0000256|RuleBase:RU363048};
GN Name=ruvbl2 {ECO:0000313|EMBL:ORM41313.1};
GN ORFNames=BXIN_0817 {ECO:0000313|EMBL:ORM41313.1};
OS Babesia sp. Xinjiang.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC Babesiidae; Babesia.
OX NCBI_TaxID=462227 {ECO:0000313|EMBL:ORM41313.1, ECO:0000313|Proteomes:UP000193856};
RN [1] {ECO:0000313|EMBL:ORM41313.1, ECO:0000313|Proteomes:UP000193856}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Xinjiang {ECO:0000313|EMBL:ORM41313.1,
RC ECO:0000313|Proteomes:UP000193856};
RX PubMed=27784333; DOI=10.1186/s13071-016-1846-1;
RA Guan G., Korhonen P.K., Young N.D., Koehler A.V., Wang T., Li Y., Liu Z.,
RA Luo J., Yin H., Gasser R.B.;
RT "Genomic resources for a unique, low-virulence Babesia taxon from China.";
RL Parasit. Vectors 9:564-564(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|RuleBase:RU363048};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the RuvB family. {ECO:0000256|ARBA:ARBA00007519,
CC ECO:0000256|RuleBase:RU363048}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORM41313.1}.
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DR EMBL; MBFZ01000031; ORM41313.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X1BMI8; -.
DR VEuPathDB; PiroplasmaDB:BXIN_0817; -.
DR OrthoDB; 5479950at2759; -.
DR Proteomes; UP000193856; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0008094; F:ATP-dependent activity, acting on DNA; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.50.360; RuvB-like helicase, domain II; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR002809; EMC3/TMCO1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR027238; RuvB-like.
DR InterPro; IPR041048; RuvB-like_C.
DR InterPro; IPR042487; RuvBL1/2_DNA/RNA_bd_dom.
DR InterPro; IPR010339; TIP49_P-loop.
DR PANTHER; PTHR11093:SF2; RUVB-LIKE 2; 1.
DR PANTHER; PTHR11093; RUVB-RELATED REPTIN AND PONTIN; 1.
DR Pfam; PF01956; EMC3_TMCO1; 1.
DR Pfam; PF06068; TIP49; 1.
DR Pfam; PF17856; TIP49_C; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM01415; DUF106; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363048};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|RuleBase:RU363048};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU363048};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363048};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU363048};
KW Reference proteome {ECO:0000313|Proteomes:UP000193856};
KW Transcription {ECO:0000256|RuleBase:RU363048};
KW Transcription regulation {ECO:0000256|RuleBase:RU363048};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 224..525
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 622..644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 644 AA; 72348 MW; 6B8914E5DD2DC9C5 CRC64;
MEDLLLVVSF AILSGALKEL TSYIFMYRRP DFQEKFKELT KRYEEYHRTF VIFEPRTSHR
NCFTVVTQRL LDITKELREL QTVYNCVNGL AFMLLMLLVM SYFEGCVVAK LPFTPIWPIS
IFTKGDAIGT DLTSCSATCI YTVLSMLVKD AIQVLLGIFD KMTHIIETSD VTKIERVGIH
SHIRGLGLDE HLNVKYQADG LVGQVQARRA AGLVVKMMNS GVIGGRGILL AGQPGSGKTA
IAIAISKALG EDTPFTHLSA SEVYSMEMSK TECLLQAFRR SVGVRVSEES EVIEGEVTEI
EIDRFTNRQV DPTSFSSAPT TVGKMTIKTT DMETLYDVGH KLIEAMRREN ITAGDVIRID
KASGTVRKLG RTYARARDYD ATGPNVKYVP CPSGELQKRQ TVTHTVTLHD IDVINSRSQG
FLALFAGDTG EIDSQIRTQI DAKIREWQAD NRAEILPGVL FIDEAHMLDI ECFSFLCRHL
ESEMCPFLIL ATNRGITNVR GTNYKSPHGI PLDLLDRLLI IPTYPFQPED TEKIILERCT
EEDVELDDES LHLLCKIASE TSLRYALQLI NAGDLIRRRR GGKSVTSADV RRAFGLFVDT
RRSTKYLVEF QHDFMFSELQ VDDDEMQAEP EAPAESQMKV DSEA
//
