ID A0A1X1BQ39_9APIC Unreviewed; 626 AA.
AC A0A1X1BQ39;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Inositol-pentakisphosphate 2-kinase {ECO:0000256|ARBA:ARBA00012023, ECO:0000256|RuleBase:RU364126};
DE EC=2.7.1.158 {ECO:0000256|ARBA:ARBA00012023, ECO:0000256|RuleBase:RU364126};
GN ORFNames=BXIN_0966 {ECO:0000313|EMBL:ORM42189.1};
OS Babesia sp. Xinjiang.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC Babesiidae; Babesia.
OX NCBI_TaxID=462227 {ECO:0000313|EMBL:ORM42189.1, ECO:0000313|Proteomes:UP000193856};
RN [1] {ECO:0000313|EMBL:ORM42189.1, ECO:0000313|Proteomes:UP000193856}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Xinjiang {ECO:0000313|EMBL:ORM42189.1,
RC ECO:0000313|Proteomes:UP000193856};
RX PubMed=27784333; DOI=10.1186/s13071-016-1846-1;
RA Guan G., Korhonen P.K., Young N.D., Koehler A.V., Wang T., Li Y., Liu Z.,
RA Luo J., Yin H., Gasser R.B.;
RT "Genomic resources for a unique, low-virulence Babesia taxon from China.";
RL Parasit. Vectors 9:564-564(2016).
CC -!- FUNCTION: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form
CC Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). {ECO:0000256|RuleBase:RU364126}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-
CC inositol hexakisphosphate + ADP + H(+); Xref=Rhea:RHEA:20313,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57733,
CC ChEBI:CHEBI:58130, ChEBI:CHEBI:456216; EC=2.7.1.158;
CC Evidence={ECO:0000256|RuleBase:RU364126};
CC -!- DOMAIN: The EXKPK motif is conserved in inositol-pentakisphosphate 2-
CC kinases of both family 1 and 2. {ECO:0000256|RuleBase:RU364126}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORM42189.1}.
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DR EMBL; MBFZ01000011; ORM42189.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X1BQ39; -.
DR VEuPathDB; PiroplasmaDB:BXIN_0966; -.
DR OrthoDB; 227351at2759; -.
DR Proteomes; UP000193856; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0035299; F:inositol pentakisphosphate 2-kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR InterPro; IPR009286; Ins_P5_2-kin.
DR PANTHER; PTHR14456; INOSITOL POLYPHOSPHATE KINASE 1; 1.
DR PANTHER; PTHR14456:SF2; INOSITOL-PENTAKISPHOSPHATE 2-KINASE; 1.
DR Pfam; PF06090; Ins_P5_2-kin; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|RuleBase:RU364126};
KW Kinase {ECO:0000256|RuleBase:RU364126};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU364126};
KW Reference proteome {ECO:0000313|Proteomes:UP000193856};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU364126}.
SQ SEQUENCE 626 AA; 71611 MW; AA15E34428BC2414 CRC64;
MRLSPLGAGN CQFVYRIDRD SWKSPEDRSV PWHQCYVLKL PRKADSATIM RRMLYHDELC
LFMQEGYRNN AESCAPKRVC CLVDRTVADR LRSHLSKLLD DYKTCTQNAT CRRNRTKVSR
DVTASVNREK VNMFHTEIVY KKRIYHVKEV ALQTAVDVDP RAICILGNKK VVYDPSKHEL
AILEEDLFNL AVCMSLGRTL LQAGMQHYRN ISVELKPKCG LLNFSGLPSL FQMSQPYKAR
IRYQNIIPSD TPKVAASILK RDPGNLTLSK YSPIRLFRMT LNDVKKELDY LARAPQNNIR
IFIDNIEVDP GVLLSDTYAM DNVARCLLEN KLTMTRVLNL QALASGQQVV AHVVYLLSRL
LTQVTVPKGN AGEDTARKVK FSTIMNNLLC LSKELLDLML CNHSNAYRIQ RAFNFIGRRL
ICSLCNVLKM LLANRRIMIY TSRRNTSMER LRTTKGNRSL PVFHNDAQAL CHKLTIYSQG
RLWKRQCSND EAVQLVVFNE LECLLTQIHR CVTYRPANPK GSVVRGKTSP IVGTTCSGEK
MERVLIKKST ALIGAAKRWI QLYLGGRTAM DISVVLNVLF HGQPDNAANG PNFFRFSLID
LDLKPAHRIP RWKEDVLFLI NQQQHY
//
