ID A0A1X1MRY0_9VIBR Unreviewed; 1146 AA.
AC A0A1X1MRY0;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN ORFNames=ST37_09435 {ECO:0000313|EMBL:ORT50129.1};
OS Vibrio sp. qd031.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=1603038 {ECO:0000313|EMBL:ORT50129.1, ECO:0000313|Proteomes:UP000193432};
RN [1] {ECO:0000313|EMBL:ORT50129.1, ECO:0000313|Proteomes:UP000193432}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=qd031 {ECO:0000313|Proteomes:UP000193432};
RA Xiang T., Song Y., Huang L., Wang B., Wu P.;
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ORT50129.1, ECO:0000313|Proteomes:UP000193432}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=qd031 {ECO:0000313|Proteomes:UP000193432};
RA Chen G.;
RT "Denovo assembling a bacteria genome.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORT50129.1}.
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DR EMBL; JXQD01000024; ORT50129.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X1MRY0; -.
DR STRING; 1603038.ST37_09435; -.
DR OrthoDB; 9804325at2; -.
DR Proteomes; UP000193432; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11140; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR048635; MFD_D3.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21132; MFD_D3; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Reference proteome {ECO:0000313|Proteomes:UP000193432}.
FT DOMAIN 618..779
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 801..954
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1146 AA; 129388 MW; 7AA13CAB7BFA0EFD CRC64;
MSATTLFSLP YSSAQGDKKQ LGSLVGAALP IAISEYAKLH QKPVILVVSD PQTALRLQQE
LDTLTEQTVS LFPDWETLPY DNFSPHQEII SDRIAHLYAM PTQTQGITIV PVSTLMQRQA
PRDYLLQHTL MIKSGDLFSL EKLRIQLEKS GYRHVDQVFG PGEYASRGSI IDLFPTGSDA
PFRIDFFDDE IDSIRTFDPE NQRSLDAIDE IRLLPAHEFP TTEEAIEDFR IRWRKQFDTR
REPESIYMQV SKGTWPAGIE YWQPLFFEQT ETLFDYFADH CLILKVGDLD SAMDKFWHDV
EYRFDQRKVD PLRPLLEPNQ LWLKKEDVYA GLKPYPQVQL HNDKISASAA NKNVALEGLP
ELTAQHQNKE PLARLRQFVE KYKGKIVFSV ESEGRREALI ELLKPLKISP TQVERYPQAI
EGDARFPLLI TSTEHGFIHS KPDFALICES DLLGDRVIQR RKKDKRAINS DTVIRHLAEL
KPGQPVVHLD HGIGRYTGLQ TLEAGGIATE YVTLEYLNEA KLYVPVASLN LISRYSGGAE
DGAPLHKLGS DSWSKARRKA AEKVRDVAAE LLDVYAKREL KPGHKFVLDR EQYAAFKTGF
PFEETDDQAM AINAVMSDMC QAKAMDRLVC GDVGFGKTEV AMRAAFLATD NSKQVAVLVP
TTLLAQQHFE NFRDRFANTA VRVEVLSRFR SAKEQKQVLA DLADGKVDIV IGTHKLLQSD
IQFSDLGLLI VDEEHRFGVR QKEKMKAMRA DVDILTLTAT PIPRTLNMAM SGMRDLSIIA
TPPARRLAIK TFVREHDDSV VREAVLREIM RGGQVYFLHN NVDTIDRVAE DLTKLLPEAR
ITTAHGQMRE RELERIMNDF YHQKFNLLVC TTIIETGIDV PTANTIIMDR ADRLGLAQLH
QLRGRVGRSH HQAYAYLLTP HPKALSKDAA KRLDAIASLE DLGAGFTLAT HDLEIRGAGE
LLGDDQSGQI QTVGFTLYMD MLEEAVEALK QGREPSLDDL LREQTEVELR LPALLPDDYI
PDINTRLSTY KRIASVNSDN ELMELKVELI DRFGQLPEPA QNLISVGELK LLAAKLHVNK
VEAHEKGGYI DFSAQATVDP MRLVKMIQSS PGEFAMGGPT KLKFMAELSD RKQRITHVKQ
LLAKFA
//
