ID A0A1X1QYX6_MYCFA Unreviewed; 443 AA.
AC A0A1X1QYX6;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Beta-ketoacyl synthase {ECO:0000313|EMBL:ORU96677.1};
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:BBY97982.1};
GN ORFNames=AWC04_19030 {ECO:0000313|EMBL:ORU96677.1}, MFAL_14490
GN {ECO:0000313|EMBL:BBY97982.1};
OS Mycolicibacterium fallax (Mycobacterium fallax).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=1793 {ECO:0000313|EMBL:ORU96677.1, ECO:0000313|Proteomes:UP000193484};
RN [1] {ECO:0000313|EMBL:ORU96677.1, ECO:0000313|Proteomes:UP000193484}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44179 {ECO:0000313|EMBL:ORU96677.1,
RC ECO:0000313|Proteomes:UP000193484};
RA Tarcisio F., Conor M., Antonella G., Elisabetta G., Giulia F.S., Sara T.,
RA Anna F., Clotilde B., Roberto B., Veronica D.S., Fabio R., Monica P.,
RA Olivier J., Enrico T., Nicola S.;
RT "The new phylogeny of the genus Mycobacterium.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:BBY97982.1, ECO:0000313|Proteomes:UP000467101}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 6405 {ECO:0000313|EMBL:BBY97982.1,
RC ECO:0000313|Proteomes:UP000467101};
RX PubMed=31287781;
RA Matsumoto Y., Kinjo T., Motooka D., Nabeya D., Jung N., Uechi K., Horii T.,
RA Iida T., Fujita J., Nakamura S.;
RT "Comprehensive subspecies identification of 175 nontuberculous mycobacteria
RT species based on 7547 genomic profiles.";
RL Emerg. Microbes Infect. 8:1043-1053(2019).
RN [3] {ECO:0000313|EMBL:BBY97982.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JCM 6405 {ECO:0000313|EMBL:BBY97982.1};
RA Matsumoto Y., Motooka D., Nakamura S.;
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|RuleBase:RU003694}.
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DR EMBL; AP022603; BBY97982.1; -; Genomic_DNA.
DR EMBL; LQOJ01000073; ORU96677.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X1QYX6; -.
DR STRING; 1793.AWC04_19030; -.
DR KEGG; mfx:MFAL_14490; -.
DR OrthoDB; 9778690at2; -.
DR Proteomes; UP000193484; Unassembled WGS sequence.
DR Proteomes; UP000467101; Chromosome.
DR GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000193484};
KW Transferase {ECO:0000256|RuleBase:RU003694}.
FT DOMAIN 13..437
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 443 AA; 46073 MW; 0B0B14491F6835FD CRC64;
MPASLTPGAD HAGDPVVIVG MALEAPGGVQ TPEQYWTLLA EQREALCAFP TDRGWDLAGL
FAGSRRDGFT PIPNLGGFLS SAAEFDAEFF GISPREASAM DPQQRVALRL AWRAVENAGI
NPDDLAGRQV GCYIGASALE YGPPLAEYSE HSGHLITGTS LGVISGRIAY LLDLAGPALT
IDTSCSSALA ALHTAVAAVR AGDCDLALTG GVAVLGSPGY FVEFAKQHAL AEDGHCRPYS
AHAAGTVWAE GAAMFLITRR SDAERDGLPV LAEVLASTLN SDGRTPGLTA PDETAQRRLV
QRALQRAGIG PADVDLVEGH GTGTRLGDRT ELRSLAASYG ATAPGTGPRL GSVKSNIGHT
QAAAGALGLA KVLVAAQHRA IPPTLHVDQR SSEIDWDAQG IRLAEKLTDW PARDGRRIAG
VSAFGMSGTN THLIVAMPER GGW
//
