ID A0A1X1QZA2_MYCFA Unreviewed; 961 AA.
AC A0A1X1QZA2;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Membrane protein {ECO:0000313|EMBL:BBY97936.1};
GN ORFNames=AWC04_19270 {ECO:0000313|EMBL:ORU96718.1}, MFAL_14030
GN {ECO:0000313|EMBL:BBY97936.1};
OS Mycolicibacterium fallax (Mycobacterium fallax).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=1793 {ECO:0000313|EMBL:ORU96718.1, ECO:0000313|Proteomes:UP000193484};
RN [1] {ECO:0000313|EMBL:ORU96718.1, ECO:0000313|Proteomes:UP000193484}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44179 {ECO:0000313|EMBL:ORU96718.1,
RC ECO:0000313|Proteomes:UP000193484};
RA Tarcisio F., Conor M., Antonella G., Elisabetta G., Giulia F.S., Sara T.,
RA Anna F., Clotilde B., Roberto B., Veronica D.S., Fabio R., Monica P.,
RA Olivier J., Enrico T., Nicola S.;
RT "The new phylogeny of the genus Mycobacterium.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:BBY97936.1, ECO:0000313|Proteomes:UP000467101}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 6405 {ECO:0000313|EMBL:BBY97936.1,
RC ECO:0000313|Proteomes:UP000467101};
RX PubMed=31287781;
RA Matsumoto Y., Kinjo T., Motooka D., Nabeya D., Jung N., Uechi K., Horii T.,
RA Iida T., Fujita J., Nakamura S.;
RT "Comprehensive subspecies identification of 175 nontuberculous mycobacteria
RT species based on 7547 genomic profiles.";
RL Emerg. Microbes Infect. 8:1043-1053(2019).
RN [3] {ECO:0000313|EMBL:BBY97936.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JCM 6405 {ECO:0000313|EMBL:BBY97936.1};
RA Matsumoto Y., Motooka D., Nakamura S.;
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
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DR EMBL; AP022603; BBY97936.1; -; Genomic_DNA.
DR EMBL; LQOJ01000073; ORU96718.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X1QZA2; -.
DR STRING; 1793.AWC04_19270; -.
DR KEGG; mfx:MFAL_14030; -.
DR Proteomes; UP000193484; Unassembled WGS sequence.
DR Proteomes; UP000467101; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR004707; MmpL_fam.
DR NCBIfam; TIGR00833; actII; 1.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000193484};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 25..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 200..217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 224..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 252..276
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 297..321
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 333..358
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 379..402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 770..789
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 796..821
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 827..850
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 871..893
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 57..387
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT DOMAIN 612..943
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
SQ SEQUENCE 961 AA; 104743 MW; EA241E6C42A1C182 CRC64;
MPDTAVVPST DTSTHRGIGR FLRKYAIGVI LAWLVLIGLL STTVPQLEVV GEMRSVSMSP
DDAPSMVAMK RVGQVFDEFK SDASAMIVLE RDGLLGDPDH VFYDDMVARM KADTEHVEHV
QDFWGDTITQ AGAQSNDGQA AYVQVFLAGN MGEALANESA QAIQKLVADL PKPDGLRVYV
TGSTALAADQ QVAGTKSVRI IELTTFAVII SMLLWTYRAI SSVLIMLSMV VMLLAAARGM
VAFLGYHNLI GLSTFATQLL VTLAIAASTD YAIFLIGRYQ EARSKGMDKE SAYYDMFHGT
AHVVLGSGMT IAGALFCLHF TNLPYFQTLG IPIAVGMAVA VLAALSLGPA IITVATRFGK
LLEPRRAMRI REWRRIGTIV VRWPLPVLLT TLALSLVGLL TLPGYHTNYN DRNYLPADLP
ANEGFAAAER HFSPARMNPE LLMIETDRDL RNPADFLVIE KVARAVFRVP GIGSVQAITR
PDGKPIDFTT IPAMLSRSGV LQDLNRPYLD KSTDNMLEQA ELMQGSIDTM NAMMTLMGQM
MGTMSVMTTK MHTMVDDVTQ LRNHLADFED FIRPLRNYLH WEPHCFNIPV CSSIRSIFNA
LDKVDPMIDN ISSMVVDMDR LNELMPQMLA TLPAQIATMK SSKAMMLTMY QTQKGMADQG
EAMQANQTAM GEAFNKANND DSFYVPPEIF TNADFKRGME NFISPDGKSV RFIVSHDADP
LTSEGIKNID AIKHAAREAI KGTPWEGSKI FLGGTASVFK DLQEGNDYDL LIAGIAAISL
IFIIMLLITR AIIASLVIVG TVLISLGSSF GLSILLWQHI IGIDLHFMVM AMAVIVLLAV
GADYNLLLVA RLKEELPAGI NTGIIRAMGG SGSVVTSAGL VFAFTMMSMV VSSMTVVAQV
GTTIGLGLLF DTLVIRAFMT PSIAALMGRW FWWPQLVRRR PLPSPWPKTP ETAGAGAGPD
G
//
